[I doubt that in today's world, I and Francis Crick would ever have had our Eureka moment.] I recently went to my staircase at Clare College, Cambridge and there were women there! he said, with an enormous measure of retrospective sexual frustration. There have been a lot of convincing studies recently about the loss of productivity in the Western male. It may be that entertainment culture now is so engaging that it keeps people satisfied. We didn't have that. Science was much more fun than listening to the radio. When you are 16 or 17 and in that inherently semi-lonely period when you are deciding whether to be an intellectual, many now don't bother.
(Response when asked how he thought the climate of scientific research had changed since he made his discovery of the structure of life in 1953.)

A fateful process is set in motion when the individual is released “to the freedom of his own impotence” and left to justify his existence by his own efforts. The autonomous individual, striving to realize himself and prove his worth, has created all that is great in literature, art, music, science and technology. The autonomous individual, also, when he can neither realize himself nor justify his existence by his own efforts, is a breeding call of frustration, and the seed of the convulsions which shake our world to its foundations.

A mathematician’s work is mostly a tangle of guesswork, analogy, wishful thinking and frustration, and proof, far from being the core of discovery, is more often than not a way of making sure that our minds are not playing tricks.

A teacher … is never a giver of "truth”; he is a guide, a pointer to the truth that the student must discover for himself. … For example, a skillful teacher might spur his student’s growth by confronting him with certain frustrations. A good teacher is a catalyst.

And I believe there are many Species in Nature, which were never yet taken notice of by Man, and consequently of no use to him, which yet we are not to think were created in vain; but it’s likely … to partake of the overflowing Goodness of the Creator, and enjoy their own Beings. But though in this sense it be not true, that all things were made for Man; yet thus far it is, that all the Creatures in the World may be some way or other useful to us, at least to exercise our Wits and Understandings, in considering and contemplating of them, and so afford us Subject of Admiring and Glorifying their and our Maker. Seeing them, we do believe and assert that all things were in some sense made for us, we are thereby obliged to make use of them for those purposes for which they serve us, else we frustrate this End of their Creation.

As a child I read a lot, and I read everything. I’d go to the library and then stay up all night reading. I used to read under the desk in school … I read all of the books on science in the library and was frustrated when there was nothing left to read.

I would have picked up the artificial heart and thrown it on the floor and walked out and said he's dead if the press had not been there.
[Recalling moments of frustration caused by difficulties during the 7½-hour surgery on Barney Clark for the first human implant of an artificial heart.]

If the fit between South America and Africa is not genetic, surely it is a device of Satan for our frustration.

It is a temptation for philosophers that they should weave a fairy tale of the adjustment of factors; and then as an appendix introduce the notion of frustration, as a secondary aspect. I suggest to you that this is the criticism to be made on the monistic idealisms of the nineteenth century, and even of the great Spinoza. It is quite incredible that the Absolute, as conceived in monistic philosophy, should evolve confusion about its own details.

Sometime in my early teens, I started feeling an inner urgency, ups and downs of excitement and frustration, caused by such unlikely occupations as reading Granville’s course of calculus ... I found this book in the attic of a friend’s apartment. Among other standard stuff, it contained the notorious epsilon-delta definition of continuous functions. After struggling with this definition for some time (it was the hot Crimean summer, and I was sitting in the shadow of a dusty apple tree), I got so angry that I dug a shallow grave for the book between the roots, buried it there, and left in disdain. Rain started in an hour. I ran back to the tree and exhumed the poor thing. Thus, I discovered that I loved it, regardless.

The attitude of the intellectual community toward America is shaped not by the creative few but by the many who for one reason or another cannot transmute their dissatisfaction into a creative impulse, and cannot acquire a sense of uniqueness and of growth by developing and expressing their capacities and talents. There is nothing in contemporary America that can cure or alleviate their chronic frustration. They want power, lordship, and opportunities for imposing action. Even if we should banish poverty from the land, lift up the Negro to true equality, withdraw from Vietnam, and give half of the national income as foreign aid, they will still see America as an air-conditioned nightmare unfit for them to live in.

The social sciences were for all those who had not yet decided what to do with their lives, and for all those whose premature frustrations led them into the sterile alleys of confrontation.

This frustration of reading the tabloid press… it would easy to become convinced that the human race is on a mission to divide things into two clean columns… Good or evil, healthy or deadly or natural or chemical… everything organic and natural is good, ignoring the fact that organic natural substances include arsenic… Everything chemical is bad, ignoring that fact the everything is chemicals. Everything is chemicals! The day they discover yoga mats are carcinogenic will be the happiest day of my life.

To eliminate the discrepancy between men's plans and the results achieved, a new approach is necessary. Morphological thinking suggests that this new approach cannot be realized through increased teaching of specialized knowledge. This morphological analysis suggests that the essential fact has been overlooked that every human is potentially a genius. Education and dissemination of knowledge must assume a form which allows each student to absorb whatever develops his own genius, lest he become frustrated. The same outlook applies to the genius of the peoples as a whole.