[Alchemists] enrich the ears of men with vain words, but empty their Pockets of their Money. Whence it appears to be no Art, but a Composition of Trifles, and inventions of mad brains.

Ces détails scientifiques qui effarouchent les fabricans d’un certain âge, ne seront qu’un jeu pour leurs enfans, quand ils auront apprit dans leurs collèges un peu plus de mathématiques et un peu moins de Latin; un peu plus de Chimie, et un peu moins de Grec!
The scientific details which now terrify the adult manufacturer will be mere trifles to his children when they shall be taught at school, a little more Mathematics and a little less Latin, a little more Chemistry, and a little less Greek.

A man who has once looked with the archaeological eye will never see quite normally. He will be wounded by what other men call trifles. It is possible to refine the sense of time until an old shoe in the bunch grass or a pile of nineteenth century beer bottles in an abandoned mining town tolls in one’s head like a hall clock.

A weak mind is like a microscope, which magnifies trifling things, but cannot receive great ones.

Archimedes was not free from the prevailing notion that geometry was degraded by being employed to produce anything useful. It was with difficulty that he was induced to stoop from speculation to practice. He was half ashamed of those inventions which were the wonder of hostile nations, and always spoke of them slightingly as mere amusements, as trifles in which a mathematician might be suffered to relax his mind after intense application to the higher parts of his science.

Every phenomenon, however trifling it be, has a cause, and a mind infinitely powerful, and infinitely well-informed concerning the laws of nature could have foreseen it from the beginning of the ages. If a being with such a mind existed, we could play no game of chance with him; we should always lose.

If a teacher is full of his subject, and can induce enthusiasm in his pupils; if his facts are concrete and naturally connected, the amount of material that an average child can assimilate without injury is as astonishing as is the little that will fag him if it is a trifle above or below or remote from him, or taught dully or incoherently.

If texts are unified by a central logic of argument, then their pictorial illustrations are integral to the ensemble, not pretty little trifles included only for aesthetic or commercial value. Primates are visual animals, and (particularly in science) illustration has a language and set of conventions all its own.

In the end, science as we know it has two basic types of practitioners. One is the educated man who still has a controlled sense of wonder before the universal mystery, whether it hides in a snail’s eye or within the light that impinges on that delicate organ. The second kind of observer is the extreme reductionist who is so busy stripping things apart that the tremendous mystery has been reduced to a trifle, to intangibles not worth troubling one’s head about.

It is curious to observe how differently these great men [Plato and Bacon] estimated the value of every kind of knowledge. Take Arithmetic for example. Plato, after speaking slightly of the convenience of being able to reckon and compute in the ordinary transactions of life, passes to what he considers as a far more important advantage. The study of the properties of numbers, he tells us, habituates the mind to the contemplation of pure truth, and raises us above the material universe. He would have his disciples apply themselves to this study, not that they may be able to buy or sell, not that they may qualify themselves to be shop-keepers or travelling merchants, but that they may learn to withdraw their minds from the ever-shifting spectacle of this visible and tangible world, and to fix them on the immutable essences of things.
Bacon, on the other hand, valued this branch of knowledge only on account of its uses with reference to that visible and tangible world which Plato so much despised. He speaks with scorn of the mystical arithmetic of the later Platonists, and laments the propensity of mankind to employ, on mere matters of curiosity, powers the whole exertion of which is required for purposes of solid advantage. He advises arithmeticians to leave these trifles, and employ themselves in framing convenient expressions which may be of use in physical researches.

It is the care we bestow on apparently trifling, unattractive detail and very troublesome minutiae which determines the result.

Lucy, dear child, mind your arithmetic. You know in the first sum of yours I ever saw there was a mistake. You had carried two (as a cab is licensed to do), and you ought, dear Lucy, to have carried but one. Is this a trifle? What would life be without arithmetic, but a scene of horrors.

The pursuits of the greatest trifles may sometimes have a very good effect. The search after the philosopher’s stone has preserved chemistry; and the following astrology so much in former ages has been the cause of astronomy’s being so much advanced in ours. Sir Isaac Newton himself has owned that he began with studying judicial astrology, and that it was his pursuits of that idle and vain study which led him into the beauties and love of astronomy.

The study of Nature is intercourse with the highest mind. You should never trifle with Nature. At her lowest her works are the works of the highest powers, the highest something in the universe, in whichever way we look at it… This is the charm of Study from Nature itself; she brings us back to absolute truth wherever we wander.

The subject may appear an insignificant one, but we shall see that it possesses some interest; and the maxim “de minimis lex non curat” [the law is not concerned with trifles] does not apply to science.

There prevails among men of letters, an opinion, that all appearance of science is particularly hateful to Women; and that therefore whoever desires to be well received in female assemblies, 'must qualify himself by a total rejection of all that is serious, rational, or important; must consider argument or criticism as perpetually interdicted; and devote all his attention to trifles, and all his eloquence to compliment.

Things are always best seen when they are a trifle mixed up, a trifle disordered; the chilly administrative neatness of museums and filing cases, of statistics and cemeteries, is an inhuman and antinatural kind of order; it is, in a word, disorder. True order belongs to Nature, which never yet has produced two identical trees or mountains or horses.

Thomas Godfrey [was] a self-taught mathematician, great in his way…. But he knew little out of his way and was not a pleasing companion, as, like most great mathematicians I have met with, he expected universal precision in everything said, and was forever denying and distinguishing upon trifles, to the disturbance of all conversation.