A man who keeps company with glaciers comes to feel tolerably insignificiant by and by. The Alps and the glaciers together are able to take every bit of conceit out of a man and reduce his self-importance to zero if he will only remain within the influence of their sublime presence long enough to give it a fair and reasonable chance to do its work.

All knowledge is good. It is impossible to say any fragment of knowledge, however insignificant or remote from one’s ordinary pursuits, may not some day be turned to account.

Astronomy taught us our insignificance in Nature.

Behold a universe so immense that I am lost in it. I no longer know where I am. I am just nothing at all. Our world is terrifying in its insignificance.

From a long view of the history of mankind—seen from, say, ten thousand years from now—there can be little doubt that the most significant event of the 19th century will be judged as Maxwell’s discovery of the laws of electrodynamics. The American Civil War will pale into provincial insignificance in comparison with this important scientific event of the same decade.

I see no reason to believe that a creator of protoplasm or primeval matter, if such there be, has any reason to be interested in our insignificant race in a tiny corner of the universe, and still less in us, as still more insignificant individuals. Again, I see no reason why the belief that we are insignificant or fortuitous should lessen our faith.

If matter is not eternal, its first emergence into being is a miracle beside which all others dwindle into absolute insignificance. But, as has often been pointed out, the process is unthinkable; the sudden apocalypse of a material world out of blank nonentity cannot be imagined; its emergence into order out of chaos when “without form and void” of life, is merely a poetic rendering of the doctrine of its slow evolution.

If someone separated the art of counting and measuring and weighing from all the other arts, what was left of each (of the others) would be, so to speak, insignificant.

Measurement has too often been the leitmotif of many investigations rather than the experimental examination of hypotheses. Mounds of data are collected, which are statistically decorous and methodologically unimpeachable, but conclusions are often trivial and rarely useful in decision making. This results from an overly rigorous control of an insignificant variable and a widespread deficiency in the framing of pertinent questions. Investigators seem to have settled for what is measurable instead of measuring what they would really like to know.

Questions of personal priority, however interesting they may be to the persons concerned, sink into insignificance in the prospect of any gain of deeper insight into the secrets of nature.