Drosophila Quotes (10 quotes)
Drosophila melanogaster has been more extensively used in the study of genetics than any other organism, and the theory of heredity that is now generally accepted is based chiefly on the results obtained with this fly. … Not only has Drosophila been the most productive material for research in the subject, but it is now the standard object for laboratory instruction, and is used as such in many colleges and universities.
In systemic searches for embryonic lethal mutants of Drosophila melanogaster we have identified 15 loci which when mutated alter the segmental patterns of the larva. These loci probably represent the majority of such genes in Drosophila. The phenotypes of the mutant embryos indicate that the process of segmentation involves at least three levels of spatial organization: the entire egg as developmental unit, a repeat unit with the length of two segments, and the individual segment.
[Co-author with American physiologist Eric Wieshaus (1947-)]
[Co-author with American physiologist Eric Wieshaus (1947-)]
The adults of Drosophila react positively to light, i.e., they go toward a source of light … whether the animals walk or fly. Removal of the wings causes the flies to become less responsive to light, … roughly proportional to the amount of the wing that is cut off. As was to be expected from this fact, mutant races with parts of the wings gone or deformed show the same relations—the smaller the amount of normal wing present, the less marked is the reaction to light.
The foundations of population genetics were laid chiefly by mathematical deduction from basic premises contained in the works of Mendel and Morgan and their followers. Haldane, Wright, and Fisher are the pioneers of population genetics whose main research equipment was paper and ink rather than microscopes, experimental fields, Drosophila bottles, or mouse cages. Theirs is theoretical biology at its best, and it has provided a guiding light for rigorous quantitative experimentation and observation.
The three of us have worked on the development of the small and totally harmless fruit fly, Drosophila. This animal has been extremely cooperative in our hands - and has revealed to us some of its innermost secrets and tricks for developing from a single celled egg to a complex living being of great beauty and harmony. ... None of us expected that our work would be so successful or that our findings would ever have relevance to medicine.
There has been a very large number of mutations discovered in the laboratory races of Drosophila melanogaster Meigen…. It…would be of considerable interest to get an idea of how these mutations compare with the differences between wild species of Drosophila.
There is a reference in Aristotle to a gnat produced by larvae engendered in the slime of vinegar. This must have been Drosophila.
There is more to biology than rats, Drosophila, Caenorhabditis, and E. coli.
We spend long hours discussing the curious situation that the two great bodies of biological knowledge, genetics and embryology, which were obviously intimately interrelated in development, had never been brought together in any revealing way. An obvious difficulty was that the most favorable organisms for genetics, Drosophila as a prime example, were not well suited for embryological study, and the classical objects of embryological study, sea urchins and frogs as examples, were not easily investigated genetically. What might we do about it? There were two obvious approaches: one to learn more about the genetics of an embryologically favourable organism, the other to better understand the development of Drosophila. We resolved to gamble up to a year of our lives on the latter approach, this in Ephrussi’s laboratory in Paris which was admirably equipped for tissue culture, tissue or organ transplantation, and related techniques.
Within the last five or six years [from 1916], from a common wild species of fly, the fruit fly, Drosophila ampelophila, which we have brought into the laboratory, have arisen over a hundred and twenty-five new types whose origin is completely known.