Characteristically skeptical of the idea that living things would faithfully follow mathematical formulas, [Robert Harper] seized upon factors in corn which seemed to blend in the hybrid—rather than be represented by plus or minus signs, and put several seasons into throwing doubt upon the concept of immutable hypothetical units of inheritance concocted to account for selected results.

For a scientist must indeed be freely imaginative and yet skeptical, creative and yet a critic. There is a sense in which he must be free, but another in which his thought must be very preceisely regimented; there is poetry in science, but also a lot of bookkeeping.

It is scientists, not sceptics, who are most willing to consider explanations that conflict with their own. And far from quashing dissent, it is the scientists, not the sceptics, who do most to acknowledge gaps in their studies and point out the limitations of their data—which is where sceptics get much of the mud they fling at the scientists. By contrast, the [sceptics] are not trying to build a theory of anything. They have set the bar much lower, and are happy muddying the waters.

Many climate sceptics seem to review scientific data and studies not as scientists but as attorneys, magnifying doubts and treating incomplete explanations as falsehoods rather than signs of progress towards the truth.

My view, the skeptical one, holds that we may be as far away from an understanding of elementary particles as Newton's successors were from quantum mechanics. Like them, we have two tremendous tasks ahead of us. One is to study and explore the mathematics of the existing theories. The existing quantum field-theories may or may not be correct, but they certainly conceal mathematical depths which will take the genius of an Euler or a Hamilton to plumb. Our second task is to press on with the exploration of the wide range of physical phenomena of which the existing theories take no account. This means pressing on with experiments in the fashionable area of particle physics. Outstanding among the areas of physics which have been left out of recent theories of elementary particles are gravitation and cosmology

Scientists can only carry on with their work, addressing legitimate questions as they arise and challenging misinformation. … Scientists work to fill the gaps in human knowledge and to build a theory that can explain observations of the world. Climate sceptics revel in such gaps, sometimes long after they have been filled.

The problems of the world cannot possibly be solved by skeptics or cynics whose horizons are limited by the obvious realities. We need men who can dream of things that never were.

The proving power of the intellect or the senses was questioned by the skeptics more than two thousand years ago; but they were browbeaten into confusion by the glory of Newtonian physics.