[Blackett] came one morning, deep in thought, into the G (technical) Office at Stanmore. It was a bitterly cold day, and the staff were shivering in a garret warmed over only with an oil-stove. Without a word of greeting, Blackett stepped silently up on to the table and stood there pondering with his feet among the plans. After ten minutes somebody coughed uneasily and said, diffidently: “Wouldn’t you like a chair, sir … or something?” “No, thank you,” said Professor Blackett, “it is necessary to apply scientific methods. Hot air rises. The warmest spot in this room, therefore, will be near the ceiling.” At this, Colonel Krohn, my technical G.S.O., stepped up on the table beside the Professor, and for the next half-hour, the two stayed there in silence. At the end of this period Professor Blackett stepped down from the table saying: “Well! That’s that problem solved.” And so it was.

Dogbert (gazing at night sky) No matter how bad the day is, the stars are always there.
Dilbert Actually, many of them burned out years ago, but their light is just now reaching earth.
DogbertThank you for shattering my comfortable misconception.
DilbertIt's the miracle of science.

A formative influence on my undergraduate self was the response of a respected elder statesmen of the Oxford Zoology Department when an American visitor had just publicly disproved his favourite theory. The old man strode to the front of the lecture hall, shook the American warmly by the hand and declared in ringing, emotional tones: “My dear fellow, I wish to thank you. I have been wrong these fifteen years.” And we clapped our hands red. Can you imagine a Government Minister being cheered in the House of Commons for a similar admission? “Resign, Resign” is a much more likely response!

Every time we get slapped down, we can say, “Thank you Mother Nature,” because it means we’re about to learn something important.

I thank you for your Expt on the Hedge Hog; but why do you ask me such a question, by way of solving it. I think your solution is just; but why think, why not try the Expt.
[Often seen, without context, briefly as: But why think, why not try the experiment?']

If Louis Pasteur were to come out of his grave because he heard that the cure for cancer still had not been found, NIH would tell him, “Of course we'll give you assistance. Now write up exactly what you will be doing during the three years of your grant.” Pasteur would say, “Thank you very much,” and would go back to his grave. Why? Because research means going into the unknown. If you know what you are going to do in science, then you are stupid! This is like telling Michelangelo or Renoir that he must tell you in advance how many reds and how many blues he will buy, and exactly how he will put those colors together.

If the only prayer you ever say in your entire life is thank you, it will be enough.

When I was … a teenager … like, 14, … the space program was getting started, and I wanted to be an astronaut. I wrote to NASA and I said, “What do I have to do to be prepared to be an astronaut?” And they wrote back and said, “Thank you very much but we’re not taking girls.” … That thankfully changed with Sally Ride and a lot of the other great women astronauts.