Chargaff_Erwins Quotes (1 quote)

I wasn’t aware of Chargaff’s rules when he said them, but the effect on me was quite electric because I realized immediately that if you had this sort of scheme that John Griffith was proposing, of adenine being paired with thymine, and guanine being paired with cytosine, then you should get Chargaff’s rules.

I was very excited, but I didn’t actually tell Chargaff because it was something I was doing with John Griffith. There was a sort of musical comedy effect where I forgot what the bases were and I had to go to the library to check, and I went back to John Griffith to find out which places he said. Low and behold, it turned out that John Griffith’s ideas fitted in with Chargaff’s rules!

This was very exciting, and we thought “ah ha!” and we realized—I mean what anyone who is familiar with the history of science ought to realize—that when you have one-to-one ratios, it means things go to together. And how on Earth no one pointed out this simple fact in those years, I don’t know.

I was very excited, but I didn’t actually tell Chargaff because it was something I was doing with John Griffith. There was a sort of musical comedy effect where I forgot what the bases were and I had to go to the library to check, and I went back to John Griffith to find out which places he said. Low and behold, it turned out that John Griffith’s ideas fitted in with Chargaff’s rules!

This was very exciting, and we thought “ah ha!” and we realized—I mean what anyone who is familiar with the history of science ought to realize—that when you have one-to-one ratios, it means things go to together. And how on Earth no one pointed out this simple fact in those years, I don’t know.