~~[Misquotation]~~ Every truth starts life as a heresy and ends life as an orthodoxy.

History warns us … that it is the customary fate of new truths to begin as heresies and to end as superstitions; and, as matters now stand, it is hardly rash to anticipate that, in another twenty years, the new generation, educated under the influences of the present day, will be in danger of accepting the main doctrines of the “Origin of Species,” with as little reflection, and it may be with as little justification, as so many of our contemporaries, twenty years ago, rejected them.

I hardly know of a great physical truth whose universal reception has not been preceded by an epoch in which the most estimable persons have maintained that the phenomena investigated were directly dependent on the Divine Will, and that the attempt to investigate them was not only futile but blasphemous. And there is a wonderful tenacity of life about this sort of opposition to physical science. Crushed and maimed in every battle, it yet seems never to be slain; and after a hundred defeats it is at this day as rampant, though happily not so mischievous, as in the time of Galileo.

I should object to any experimentation which can justly be called painful, for the purpose of elementary instruction ... [but I regret] a condition of the law which permits a boy to troll for pike, or set lines with live frog bait, for idle amusement; and, at the same time, lays the teacher of that boy open to the penalty of fine and imprisonment, if he uses the same animal for the purpose of exhibiting one of the most beautiful and instructive of physiological spectacles, the circulation in the web of the foot. ... [Maybe the frog is] inconvenienced by being wrapped up in a wet rag, and having his toes tied out ... But you must not inflict the least pain on a vertebrated animal for scientific purposes (though you may do a good deal in that way for gain or for sport) without due licence of the Secretary of State for the Home Department, granted under the authority of the Vivisection Act.
... [Yet, in] 1877, two persons may be charged with cruelty to animals. One has impaled a frog, and suffered the creature to writhe about in that condition for hours; the other has pained the animal no more than one of us would be pained by tying strings round his fingers, and keeping him in the position of a hydropathic patient. The first offender says, 'I did it because I find fishing very amusing,' and the magistrate bids him depart in peace; nay, probably wishes him good sport. The second pleads, 'I wanted to impress a scientific truth, with a distinctness attainable in no other way, on the minds of my scholars,' and the magistrate fines him five pounds.
I cannot but think that this is an anomalous and not wholly creditable state of things.

Irrationally held truths may be more harmful than reasoned errors.

It is the customary fate of new truths to begin as heresies and to end as superstitions.

It was badly received by the generation to which it was first addressed, and the outpouring of angry nonsense to which it gave rise is sad to think upon. But the present generation will probably behave just as badly if another Darwin should arise, and inflict upon them that which the generality of mankind most hate—the necessity of revising their convictions. Let them, then, be charitable to us ancients; and if they behave no better than the men of my day to some new benefactor, let them recollect that, after all, our wrath did not come to much, and vented itself chiefly in the bad language of sanctimonious scolds. Let them as speedily perform a strategic right-about-face, and follow the truth wherever it leads.

Science has fulfilled her function when she has ascertained and enunciated truth.

Science seems to me to teach in the highest and strongest manner the great truth which is embodied in the Christian conception of entire surrender to the will of God. Sit down before fact as a little child, be prepared to give up every preconceived notion, follow humbly wherever and to whatever abysses nature leads, or you shall learn nothing. I have only begun to learn content and peace of mind since I have resolved at all risks to do this.

Suppose it were perfectly certain that the life and fortune of every one of us would, one day or other, depend upon his winning or losing a game of chess. Don't you think that we should all consider it to be a primary duty to learn at least the names and the moves of the pieces; to have a notion of a gambit, and a keen eye for all the means of giving and getting out of check? Do you not think that we should look with a disapprobation amounting to scorn upon the father who allowed his son, or the state which allowed its members, to grow up without knowing a pawn from a knight?
Yet, it is a very plain and elementary truth that the life, the fortune, and the happiness of every one of us, and, more or less, of those who are connected with us, do depend upon our knowing something of the rules of a game infinitely more difficult and complicated than chess. It is a game which has been played for untold ages, every man and woman of us being one of the two players in a game of his or her own. The chess-board is the world, the pieces are the phenomena of the universe, the rules of the game are what we call the laws of nature. The player on the other side is hidden from us. We know that his play is always fair, just, and patient. But also we know, to our cost, that he never overlooks a mistake, or makes the smallest allowance for ignorance. To the man who plays well the highest stakes are paid with that sort of overflowing generosity with which the strong shows delight in strength. And one who plays ill is checkmated—without haste, but without remorse.

The scientific spirit is of more value than its products, and irrationally held truths may be more harmful than reasoned errors.

Time, whose tooth gnaws away everything else, powerless against truth.