A body of work such as Pasteur's is inconceivable in our time: no man would be given a chance to create a whole science. Nowadays a path is scarcely opened up when the crowd begins to pour in.

All geologic history is full of the beginning and the ends of species–of their first and last days; but it exhibits no genealogies of development.

And do you know what 'the world' is to me? Shall I,show it to you in my mirror? This world: a monster of energy, without beginning, without end; a firm, iron magnitude of force that does not grow bigger or smaller, that does not expend itself but only transforms itself; as a whole, of unalterable size, a household without expenses or losses, but likewise without increase or income; enclosed by 'nothingness' as by a boundary; not by something blurry or wasted, not something endlessly extended, but set in a definite space as a definite force, and not a space that might be 'empty' here or there, but rather as force throughout, as a play of forces and waves of forces, at the same time one and many, increasing here and at the same time decreasing there; a sea of forces flowing and rushing together, eternally changing, eternally flooding back, with tremendous years of recurrence, with an ebb and a flood of its forms; out of the simplest forms striving toward the most complex, out of the stillest, most rigid, coldest forms toward the hottest, most turbulent, most self-contradictory, and then again returning home to the simple out of this abundance, out of the play of contradictions back to the joy of concord, still affirming itself in this uniformity of its courses and its years, blessing itself as that which must return eternally, as a becoming that knows no satiety, no disgust, no weariness: this, my Dionysian world of the eternally self-creating, the eternally self-destroying, this mystery world of the twofold voluptuous delight, my 'beyond good and evil,' without goal, unless the joy of the circle itself is a goal; without will, unless a ring feels good will toward itself-do you want a name for this world? A solution for all its riddles? A light for you, too, you best-concealed, strongest, most intrepid, most midnightly men?—This world is the will to power—and nothing besides! And you yourselves are also this will to power—and nothing besides!

As evolutionary time is measured, we have only just turned up and have hardly had time to catch breath, still marveling at our thumbs, still learning to use the brand-new gift of language. Being so young, we can be excused all sorts of folly and can permit ourselves the hope that someday, as a species, we will begin to grow up.

At the end of the book [Zoonomia] he sums up his [Erasmus Darwin] views in the following sentences: “The world has been evolved, not created: it has arisen little by little from a small beginning, and has increased through the activity of the elemental forces embodied in itself, and so has rather grown than come into being at an almighty word.” “What a sublime idea of the infinite might of the great Architect, the Cause of all causes, the Father of all fathers, the Ens Entium! For if we would compare the Infinite, it would surely require a greater Infinite to cause the causes of effects than to produce the effects themselves.”
[This is a restatement, not a verbatim quote of the original words of Erasmus Darwin, who attributed the idea he summarized to David Hume.]

Both Religion and science require faith in God. For believers, God is in the beginning, and for physicists He is at the end of all considerations.

Bread has been made (indifferent) from potatoes;
And galvanism has set some corpses grinning,
But has not answer'd like the apparatus
Of the Humane Society's beginning,
By which men are unsuffocated gratis:
What wondrous new machines have late been spinning.

Ever so often in the history of human endeavour, there comes a breakthrough that takes humankind across a frontier into a new era. ... today's announcement is such a breakthrough, a breakthrough that opens the way for massive advancement in the treatment of cancer and hereditary diseases. And that is only the beginning.

Every phenomenon, however trifling it be, has a cause, and a mind infinitely powerful, and infinitely well-informed concerning the laws of nature could have foreseen it from the beginning of the ages. If a being with such a mind existed, we could play no game of chance with him; we should always lose.

Experience is never at fault; it is only your judgment that is in error in promising itself such results from experience as are not caused by our experiments. For having given a beginning, what follows from it must necessarily be a natural development of such a beginning, unless it has been subject to a contrary influence, while, if it is affected by any contrary influence, the result which ought to follow from the aforesaid beginning will be found to partake of this contrary influence in a greater or less degree in proportion as the said influence is more or less powerful than the aforesaid beginning.

Fear is the main source of superstition, and one of the main sources of cruelty. To conquer fear is the beginning of wisdom, in the pursuit of truth as in the endeavour after a worthy manner of life.?

For what are the whales being killed? For a few hundred jobs and products that are not needed, since there are cheap substitutes. If this continues, it will be the end of living and the beginning of survival. The world is being totaled.

How strange it would be if the final theory were to be discovered in our lifetimes! The discovery of the final laws of nature will mark a discontinuity in human intellectual history, the sharpest that has occurred since the beginning of modern science in the seventeenth century. Can we now imagine what that would be like?

I am entitled to say, if I like, that awareness exists in all the individual creatures on the planet—worms, sea urchins, gnats, whales, subhuman primates, superprimate humans, the lot. I can say this because we do not know what we are talking about: consciousness is so much a total mystery for our own species that we cannot begin to guess about its existence in others.

I don't dawdle. I'm a surgeon. I make an incision, do what needs to be done and sew up the wound. There is a beginning, a middle, and an end.
[On writing.]

I then began to study arithmetical questions without any great apparent result, and without suspecting that they could have the least connexion with my previous researches. Disgusted at my want of success, I went away to spend a few days at the seaside, and thought of entirely different things. One day, as I was walking on the cliff, the idea came to me, again with the same characteristics of conciseness, suddenness, and immediate certainty, that arithmetical transformations of indefinite ternary quadratic forms are identical with those of non-Euclidian geometry.

If physics leads us today to a world view which is essentially mystical, it returns, in a way, to its beginning, 2,500 years ago. ... This time, however, it is not only based on intuition, but also on experiments of great precision and sophistication, and on a rigorous and consistent mathematical formalism.

If there is an underlying oneness of all things, it does not matter where we begin, whether with stars, or laws of supply and demand, or frogs, or Napoleon Bonaparte. One measures a circle, beginning anywhere.

Imagination is the beginning of creation. You imagine what you desire, you will what you imagine and at last you create what you will.

In my work I now have the comfortable feeling that I am so to speak on my own ground and territory and almost certainly not competing in an anxious race and that I shall not suddenly read in the literature that someone else had done it all long ago. It is really at this point that the pleasure of research begins, when one is, so to speak, alone with nature and no longer worries about human opinions, views and demands. To put it in a way that is more learned than clear: the philological aspect drops out and only the philosophical remains.

In science its main worth is temporary, as a stepping-stone to something beyond. Even [Newton's] Principia … is truly but the beginning of a natural philosophy.
Co-author with his brother Julius Hare.

In the beginning (if there was such a thing), God created Newton’s laws of motion together with the necessary masses and forces. This is all; everything beyond this follows from the development of appropriate mathematical methods by means of deduction.

In the beginning was the book of Nature. For eon after eon, the pages of the book turned with no human to read them. No eye wondered at the ignition of the sun, the coagulation of the earth, the birth of the moon, the solidification of a terrestrial continent, or the filling of the seas. Yet when the first primitive algae evolved to float on the waters of this ocean, a promise was born—a hope that someday all the richness and variety of the phenomena of the universe would be read with appreciative eyes.

It is a capital mistake to theorize before one has data. Insensibly one begins to twist facts to suit theories, instead of theories to suit facts.

It is a common observation that a science first begins to be exact when it is quantitatively treated. What are called the exact sciences are no others than the mathematical ones.

It is God who is the ultimate reason things, and the Knowledge of God is no less the beginning of science than his essence and will are the beginning of things.

It is very difficult to say nowadays where the suburbs of London come to an end and where the country begins. The railways, instead of enabling Londoners to live in the country have turned the countryside into a city.

It... [can] be easily shown:
1. That all present mountains did not exist from the beginning of things.
2. That there is no growing of mountains.
3. That the rocks or mountains have nothing in common with the bones of animals except a certain resemblance in hardness, since they agree in neither matter nor manner of production, nor in composition, nor in function, if one may be permitted to affirm aught about a subject otherwise so little known as are the functions of things.
4. That the extension of crests of mountains, or chains, as some prefer to call them, along the lines of certain definite zones of the earth, accords with neither reason nor experience.
5. That mountains can be overthrown, and fields carried over from one side of a high road across to the other; that peaks of mountains can be raised and lowered, that the earth can be opened and closed again, and that other things of this kind occur which those who in their reading of history wish to escape the name of credulous, consider myths.

My present and most fixed opinion regarding the nature of alcoholic fermentation is this: The chemical act of fermentation is essentially a phenomenon correlative with a vital act, beginning and ending with the latter. I believe that there is never any alcoholic fermentation without their being simultaneously the organization, development, multiplication of the globules, or the pursued, continued life of globules which are already formed.

New ideas seem like frightening ghosts to people at the beginning; they run away from them for a long time, but they get tired of it in the end!

See, thro' this air, this ocean, and this earth,
All matter quick, and bursting into birth.
Above, how high progressive life may go!
Around, how wide! how deep extend below!
Vast chain of being, which from God began,
Natures ethereal, human, angel, man,
Beast, bird, fish, insect! what no eye can see,
No glass can reach! from Infinite to thee,
From thee to Nothing—On superior pow'rs
Were we to press, inferior might on ours:
Or in the full creation leave a void,
Where, one step broken, the great scale's destroy'd:
From Nature's chain whatever link you strike,
Tenth or ten thousandth, breaks the chain alike.

Taking mathematics from the beginning of the world to the time when Newton lived, what he had done was much the better half.

The Author of nature has not given laws to the universe, which, like the institutions of men, carry in themselves the elements of their own destruction; he has not permitted in his works any symptom of infancy or of old age, or any sign by which we may estimate either their future or their past duration. He may put an end, as he no doubt gave a beginning, to the present system at some determinate period of time; but we may rest assured, that this great catastrophe will not be brought about by the laws now existing, and that it is not indicated by any thing which we perceive.

The framing of hypotheses is, for the enquirer after truth, not the end, but the beginning of his work. Each of his systems is invented, not that he may admire it and follow it into all its consistent consequences, but that he may make it the occasion of a course of active experiment and observation. And if the results of this process contradict his fundamental assumptions, however ingenious, however symmetrical, however elegant his system may be, he rejects it without hesitation. He allows no natural yearning for the offspring of his own mind to draw him aside from the higher duty of loyalty to his sovereign, Truth, to her he not only gives his affections and his wishes, but strenuous labour and scrupulous minuteness of attention.

The greatest achievements in the science of this [twentieth] century are themselves the sources of more puzzlement than human beings have ever experienced. Indeed, it is likely that the twentieth century will be looked back at as the time when science provided the first close glimpse of the profundity of human ignorance. We have not reached solutions; we have only begun to discover how to ask questions.

The honor you have given us goes not to us as a crew, but to ... all Americans, who believed, who persevered with us. What Apollo has begun we hope will spread out in many directions, not just in space, but underneath the seas, and in the cities to tell us unforgettably what we will and must do. There are footprints on the moon. Those footprints belong to each and every one of you, to all mankind. They are there because of the blood, sweat, and tears of millions of people. Those footprints are the symbol of true human spirit.

The improvement of forest trees is the work of centuries. So much more the reason for beginning now.

The late Mr. David Hume, in his posthumous works, places the powers of generation much above those of our boasted reason; and adds, that reason can only make a machine, as a clock or a ship, but the power of generation makes the maker of the machine; ... he concludes, that the world itself might have been generated, rather than created ; that is, it might have been gradually produced from very small beginnings, increasing by the activity of its inherent principles, rather than by a sudden evolution of the whole by the Almighty fiat.—What a magnificent idea of the infinite power of THE GREAT ARCHITECT! THE CAUSE OF CAUSES! PARENT OF PARENTS! ENS ENTIUM!
For if we may compare infinities, it would seem to require a greater infinity of power to cause the causes of effects, than to cause the effects themselves.

The principles of Geology like those of geometry must begin at a point, through two or more of which the Geometrician draws a line and by thus proceeding from point to point, and from line to line, he constructs a map, and so proceeding from local to gen maps, and finally to a map of the world. Geometricians founded the science of Geography, on which is based that of Geology.

The self-fulfilling prophecy is, in the beginning, a false definition of the situation evoking a new behavior which makes the originally false conception come true. The specious validity of the self-fulfilling prophecy perpetuates a reign of error. For the prophet will cite the actual course of events as proof that he was right from the very beginning... Such are the perversities of social logic.

The starting point of Darwin's theory of evolution is precisely the existence of those differences between individual members of a race or species which morphologists for the most part rightly neglect. The first condition necessary, in order that any process of Natural Selection may begin among a race, or species, is the existence of differences among its members; and the first step in an enquiry into the possible effect of a selective process upon any character of a race must be an estimate of the frequency with which individuals, exhibiting any given degree of abnormality with respect to that, character, occur. The unit, with which such an enquiry must deal, is not an individual but a race, or a statistically representative sample of a race; and the result must take the form of a numerical statement, showing the relative frequency with which the various kinds of individuals composing the race occur.

The theory of the earth is the science which describes and explains changes that the terrestrial globe has undergone from its beginning until today, and which allows the prediction of those it shall undergo in the future. The only way to understand these changes and their causes is to study the present-day state of the globe in order to gradually reconstruct its earlier stages, and to develop probable hypotheses on its future state. Therefore, the present state of the earth is the only solid base on which the theory can rely.

The validity of all the Inductive Methods depends on the assumption that every event, or the beginning of every phenomenon, must have some cause; some antecedent, upon the existence of which it is invariably and unconditionally consequent.

The year 1896 ... marked the beginning of what has been aptly termed the heroic age of Physical Science. Never before in the history of physics has there been witnessed such a period of intense activity when discoveries of fundamental importance have followed one another with such bewildering rapidity.

There are as many species as the infinite being created diverse forms in the beginning, which, following the laws of generation, produced many others, but always similar to them: therefore there are as many species as we have different structures before us today.

There can be no thought of finishing, for aiming at the stars, both literally and figuratively, is the work of generations, but no matter how much progress one makes there is always the thrill of just beginning.

This is a huge step toward unraveling Genesis Chapter 1, Verse 1—what happened in the beginning. This is a Genesis machine. It'll help to recreate the most glorious event in the history of the universe.
[Comment on a milestone experiment, the collision of two proton beams at higher energy than ever before, upon the restarting of the Large Hadron Collider after a major failure and shutdown for repair.]

We have the satisfaction to find, that in nature there is wisdom, system and consistency. For having, in the natural history of this earth, seen a succession of worlds, we may from this conclude that, there is a system in nature; in like manner as, from seeing revolutions of the planets, it is concluded, that there is a system by which they are intended to continue those revolutions. But if the succession of worlds is established in the system of nature, it is vain to look for anything higher in the origin of the earth. The result, therefore, of our present enquiry is, that we find no vestige of a beginning,-no prospect of an end.

We may... have to relinquish the notion, explicit or implicit, that changes of paradigm carry scientists and those who learn from them closer and closer to the truth... The developmental process described in this essay has been a process of evolution from primitive beginnings—a process whose successive stages are characterized by an increasingly detailed and refined understanding of nature. But nothing that has been or will be said makes it a process of evolution toward anything.

We were very privileged to leave on the Moon a plaque ... saying, ‘For all Mankind’. Perhaps in the third millennium a wayward stranger will read the plaque at Tranquility Base. We’ll let history mark that this was the age in which that became a fact. I was struck this morning in New York by a proudly waved but uncarefully scribbled sign. It said, ‘Through you we touched the Moon.’ It was our privilege today to touch America. I suspect perhaps the most warm, genuine feeling that all of us could receive came through the cheers and shouts and, most of all, the smiles of our fellow Americans. We hope and think that those people shared our belief that this is the beginning of a new era—the beginning of an era when man understands the universe around him, and the beginning of the era when man understands himself.

Where the telescope ends, the microscope begins. Which of the two has the grander view?

[About any invention] (1) everything that’s already in the world when you’re born is just normal; (2) anything that gets invented between then and before you turn thirty is incredibly exciting and creative and with any luck you can make a career out of it; (3) anything that gets invented after you’re thirty is against the natural order of things and the beginning of the end of civilisation as we know it until it’s been around for about ten years when it gradually turns out to be alright really.

[I] could see how nervous everybody was in the beginning and how silent it was when we had trouble with the artificial heart [during the surgery, but later in the operation, when it was working, there were moments] of loud and raucous humor.
[Commenting after reviewing the video tape of the world's first human implantation of an artificial heart.]

“In the beginning... rdquo; Whatever our speculations may be in regard to a “beginning,” and when it was, it is written in the rocks that, like the animals and plants ... , the earth itself grew.

“She can’t do Subtraction.” said the White Queen. “Can you do Division? Divide a loaf by a knife—what's the answer to that?”
“I suppose-” Alice was beginning, but the Red Queen answered for her.
“Bread-and-butter, of course.”