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Who said: “As far as the laws of mathematics refer to reality, they are not certain; and as far as they are certain, they do not refer to reality.”
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Observation Quotes (264 quotes)


... there is an external world which can in principle be exhaustively described in scientific language. The scientist, as both observer and language-user, can capture the external facts of the world in prepositions that are true if they correspond to the facts and false if they do not. Science is ideally a linguistic system in which true propositions are in one-to-one relation to facts, including facts that are not directly observed because they involve hidden entities or properties, or past events or far distant events. These hidden events are described in theories, and theories can be inferred from observation, that is the hidden explanatory mechnism of the world can be discovered from what is open to observation. Man as scientist is regarded as standing apart from the world and able to experiment and theorize about it objectively and dispassionately.
'Introduction', Revolutions and Reconstructions in the Philosophy of Science (1981), xii. In John Templeton and Robert L. Herrmann, Is God the Only Reality (1994), 11-12.
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...learning chiefly in mathematical sciences can so swallow up and fix one's thought, as to possess it entirely for some time; but when that amusement is over, nature will return, and be where it was, being rather diverted than overcome by such speculations.
An Exposition of the Thirty-nine Articles of the Church of England (1850), 154
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...they have never affirm'd any thing, concerning the Cause, till the Trial was past: whereas, to do it before, is a most venomous thing in the making of Sciences; for whoever has fix'd on his Cause, before he experimented; can hardly avoid fitting his Experiment to his Observations, to his own Cause, which he had before imagin'd; rather than the Cause to the Truth of the Experiment itself.
Referring to experiments of the Aristotelian mode, whereby a preconceived truth would be illustrated merely to convince people of the validity of the original thought.
Thomas Sprat, Abraham Cowley, History of the Royal Society (1667, 1734), 108.
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Dans les champs de l’observation le hasard ne favorise que les esprits préparés.
In the field of observation, chance favours only the prepared mind.
Inaugural Address as newly appointed Professor and Dean (Sep 1854) at the opening of the new Faculté des Sciences at Lille (7 Dec 1854). In René Vallery-Radot, The Life of Pasteur, translated by Mrs. R. L. Devonshire (1919), 76.
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En un mot, pour tirer la loi de l'expérience, if faut généraliser; c'est une nécessité qui s'impose ŕ l'observateur le plus circonspect.
In one word, to draw the rule from experience, one must generalize; this is a necessity that imposes itself on the most circumspect observer.
La valeur de la science. In Anton Bovier, Statistical Mechanics of Disordered Systems (2006), 186.
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Forging differs from hoaxing, inasmuch as in the later the deceit is intended to last for a time, and then be discovered, to the ridicule of those who have credited it; whereas the forger is one who, wishing to acquire a reputation for science, records observations which he has never made.
Reflections on the Decline of Science in England (1830). In Calyampudi Radhakrishna Rao, Statistics and Truth (1997), 84.
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Notatio naturae, et animadversio perperit artem
Art is born of the observation and investigation of nature.
In Jon R. Stone, The Routledge Dictionary of Latin Quotations (2005), 78.
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Of Cooking. This is an art of various forms, the object of which is to give ordinary observations the appearance and character of those of the highest degree of accuracy. One of its numerous processes is to make multitudes of observations, and out of these to select only those which agree, or very nearly agree. If a hundred observations are made, the cook must be very unhappy if he cannot pick out fifteen or twenty which will do for serving up.
Reflections on the Decline of Science in England (1830). In Calyampudi Radhakrishna Rao, Statistics and Truth (1997), 84.
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Question: How would you disprove, experimentally, the assertion that white light passing through a piece of coloured glass acquires colour from the glass? What is it that really happens?
Answer: To disprove the assertion (so repeatedly made) that “white light passing through a piece of coloured glass acquires colour from the glass,” I would ask the gentleman to observe that the glass has just as much colour after the light has gone through it as it had before. That is what would really happen.
Genuine student answer* to an Acoustics, Light and Heat paper (1880), Science and Art Department, South Kensington, London, collected by Prof. Oliver Lodge. Quoted in Henry B. Wheatley, Literary Blunders (1893), 178, Question 8. (*From a collection in which Answers are not given verbatim et literatim, and some instances may combine several students' blunders.)
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Rassemblons des faits pour nous donner des idées.
Let us gather facts in order to get ourselves thinking.
'Histoire des Animaux', Histoire Naturelle, Générale et Particulière, avec la Description du Cabinet du Roi (1749), Vol. 2, 18. Quoted in Jacques Roger, The Life Sciences in Eighteenth- Century French Thought, ed. Keith R. Benson and trans. Robert Ellrich (1997), 440.
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That was excellently observ'd, say I, when I read a Passage in an Author, where his Opinion agrees with mine. When we differ, there I pronounce him to be mistaken.
In 'Thoughts On Various Subjects' (1727), collected in The Works of Jonathan Swift (1746), Vol. 1, 318.
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[Colonel Ross:]“Is there any point to which you would wish to draw my attention?”
[Sherlock Holmes:]“To the curious incident of the dog in the night-time.”
“The dog did nothing in the night-time.”
“That was the curious incident.”
Fiction from 'XIII—The Adventure of the Silver Blaze', Adventures of Sherlock Holmes, in The Strand Magazine: An Illustrated Monthly (Dec 1892), Vol. 4, 656-657.

[Sherlock Holmes:] The temptation to form premature theories upon insufficient data is the bane of our profession.
In The Valley of Fear (1914), 43.

A physician's subject of study is necessarily the patient, and his first field for observation is the hospital. But if clinical observation teaches him to know the form and course of diseases, it cannot suffice to make him understand their nature; to this end he must penetrate into the body to find which of the internal parts are injured in their functions. That is why dissection of cadavers and microscopic study of diseases were soon added to clinical observation. But to-day these various methods no longer suffice; we must push investigation further and, in analyzing the elementary phenomena of organic bodies, must compare normal with abnormal states. We showed elsewhere how incapable is anatomy alone to take account of vital phenenoma, and we saw that we must add study of all physico-chemical conditions which contribute necessary elements to normal or pathological manifestations of life. This simple suggestion already makes us feel that the laboratory of a physiologist-physician must be the most complicated of all laboratories, because he has to experiment with phenomena of life which are the most complex of all natural phenomena.
An Introduction to the Study of Experimental Medicine (1865), trans. Henry Copley Green (1957), 140-1.
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About thirty years ago there was much talk that geologists ought only to observe and not theorise; and I well remember some one saying that at this rate a man might as well go into a gravel-pit and count the pebbles and describe the colours. How odd it is that anyone should not see that all observation must be for or against some view if it is to be of any service!
Letter to Henry Fawcett (18 Sep 1861). In Charles Darwin, Francis Darwin, Albert Charles Seward, More Letters of Charles Darwin (1903), Vol. 1, 195.
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Accuracy of observation is the equivalent of accuracy of thinking.
Adagia. In Opus Postumous: Poems, Plays, Prose (1958), 158.
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Almost all the greatest discoveries in astronomy have resulted from what we have elsewhere termed Residual Phenomena, of a qualitative or numerical kind, of such portions of the numerical or quantitative results of observation as remain outstanding and unaccounted for, after subducting and allowing for all that would result from the strict application of known principles.
Outlines of Astronomy (1876), 626.
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Almost everyone... seems to be quite sure that the differences between the methodologies of history and of the natural sciences are vast. For, we are assured, it is well known that in the natural sciences we start from observation and proceed by induction to theory. And is it not obvious that in history we proceed very differently? Yes, I agree that we proceed very differently. But we do so in the natural sciences as well.
In both we start from myths—from traditional prejudices, beset with error—and from these we proceed by criticism: by the critical elimination of errors. In both the role of evidence is, in the main, to correct our mistakes, our prejudices, our tentative theories—that is, to play a part in the critical discussion, in the elimination of error. By correcting our mistakes, we raise new problems. And in order to solve these problems, we invent conjectures, that is, tentative theories, which we submit to critical discussion, directed towards the elimination of error.
The Myth of the Framework: In Defence of Science and Rationality (1993), 140.
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Although [Charles Darwin] would patiently go on repeating experiments where there was any good to be gained, he could not endure having to repeat an experiment which ought, if complete care had been taken, to have told its story at first—and this gave him a continual anxiety that the experiment should not be wasted; he felt the experiment to be sacred, however slight a one it was. He wished to learn as much as possible from an experiment, so that he did not confine himself to observing the single point to which the experiment was directed, and his power of seeing a number of other things was wonderful. ... Any experiment done was to be of some use, and ... strongly he urged the necessity of keeping the notes of experiments which failed, and to this rule he always adhered.
In Charles Darwin: His Life Told in an Autobiographical Chapter, and in a Selected Series of his Published Letters (1908), 92.
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Among those whom I could never pursuade to rank themselves with idlers, and who speak with indignation of my morning sleeps and nocturnal rambles, one passes the day in catching spiders, that he may count their eyes with a microscope; another exhibits the dust of a marigold separated from the flower with a dexterity worthy of Leuwenhoweck himself. Some turn the wheel of electricity; some suspend rings to a lodestone, and find that what they did yesterday, they can do again to-day.—Some register the changes of the wind, and die fully convinced that the wind is changeable.—There are men yet more profound, who have heard that two colorless liquors may produce a color by union, and that two cold bodies will grow hot of they are mingled: they mingle them, and produce the effect expected, say it is strange, and mingle them again.
In Tryon Edwards, A Dictionary of Thoughts (1908), 243.
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An experiment differs from an observation in this, that knowledge gained through observation seems to appear of itself, while that which an experiment brings us is the fruit of an effort that we make, with the object of knowing whether something exists or does not exist.
Traité sur l'expérience en médecine (1774), Vol. 1, 45. In Claude Bernard, Henry C. Greene, L. J. Henderson, An Introduction to the Study of Experimental Medicine (1957), 6.
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Analogy is a wonderful, useful and most important form of thinking, and biology is saturated with it. Nothing is worse than a horrible mass of undigested facts, and facts are indigestible unless there is some rhyme or reason to them. The physicist, with his facts, seeks reason; the biologist seeks something very much like rhyme, and rhyme is a kind of analogy.... This analogizing, this fine sweeping ability to see likenesses in the midst of differences is the great glory of biology, but biologists don't know it.... They have always been so fascinated and overawed by the superior prestige of exact physical science that they feel they have to imitate it.... In its central content, biology is not accurate thinking, but accurate observation and imaginative thinking, with great sweeping generalizations.
In Science is a Sacred Cow (1950), 98-100.
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And from this such small difference of eight minutes [of arc] it is clear why Ptolemy, since he was working with bisection [of the linear eccentricity], accepted a fixed equant point... . For Ptolemy set out that he actually did not get below ten minutes [of arc], that is a sixth of a degree, in making observations. To us, on whom Divine benevolence has bestowed the most diligent of observers, Tycho Brahe, from whose observations this eight-minute error of Ptolemy's in regard to Mars is deduced, it is fitting that we accept with grateful minds this gift from God, and both acknowledge and build upon it. So let us work upon it so as to at last track down the real form of celestial motions (these arguments giving support to our belief that the assumptions are incorrect). This is the path I shall, in my own way, strike out in what follows. For if I thought the eight minutes in [ecliptic] longitude were unimportant, I could make a sufficient correction (by bisecting the [linear] eccentricity) to the hypothesis found in Chapter 16. Now, because they could not be disregarded, these eight minutes alone will lead us along a path to the reform of the whole of Astronomy, and they are the matter for a great part of this work.
Astronomia Nova, New Astronomy (1609), ch. 19, 113-4, Johannes Kepler Gesammelte Werke (1937-), Vol. 3, 177-8.
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And if you want the exact moment in time, it was conceived mentally on 8th March in this year one thousand six hundred and eighteen, but submitted to calculation in an unlucky way, and therefore rejected as false, and finally returning on the 15th of May and adopting a new line of attack, stormed the darkness of my mind. So strong was the support from the combination of my labour of seventeen years on the observations of Brahe and the present study, which conspired together, that at first I believed I was dreaming, and assuming my conclusion among my basic premises. But it is absolutely certain and exact that the proportion between the periodic times of any two planets is precisely the sesquialterate proportion of their mean distances.
Harmonice Mundi, The Harmony of the World (1619), book V, ch. 3. Trans. E. J. Aiton, A. M. Duncan and J. V. Field (1997), 411.
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Any opinion as to the form in which the energy of gravitation exists in space is of great importance, and whoever can make his opinion probable will have, made an enormous stride in physical speculation. The apparent universality of gravitation, and the equality of its effects on matter of all kinds are most remarkable facts, hitherto without exception; but they are purely experimental facts, liable to be corrected by a single observed exception. We cannot conceive of matter with negative inertia or mass; but we see no way of accounting for the proportionality of gravitation to mass by any legitimate method of demonstration. If we can see the tails of comets fly off in the direction opposed to the sun with an accelerated velocity, and if we believe these tails to be matter and not optical illusions or mere tracks of vibrating disturbance, then we must admit a force in that direction, and we may establish that it is caused by the sun if it always depends upon his position and distance.
Letter to William Huggins (13 Oct 1868). In P. M. Hannan (ed.), The Scientific Letters and Papers of James Clerk Maxwell (1995), Vol. 2, 1862-1873, 451-2.
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As historians, we refuse to allow ourselves these vain speculations which turn on possibilities that, in order to be reduced to actuality, suppose an overturning of the Universe, in which our globe, like a speck of abandoned matter, escapes our vision and is no longer an object worthy of our regard. In order to fix our vision, it is necessary to take it such as it is, to observe well all parts of it, and by indications infer from the present to the past.
'Second Discours: Histoire et Theorie de la Terre', Histoire Naturelle, Ginerale et Particuličre, Avec la Description du Cabinet du Roi (1749), Vol. 1, 98-9. Trans. Phillip R. Sloan.

As I show you this liquid, I too could tell you, 'I took my drop of water from the immensity of creation, and I took it filled with that fecund jelly, that is, to use the language of science, full of the elements needed for the development of lower creatures. And then I waited, and I observed, and I asked questions of it, and I asked it to repeat the original act of creation for me; what a sight it would be! But it is silent! It has been silent for several years, ever since I began these experiments. Yes! And it is because I have kept away from it, and am keeping away from it to this moment, the only thing that it has not been given to man to produce, I have kept away from it the germs that are floating in the air, I have kept away from it life, for life is the germ, and the germ is life.'
Quoted in Patrice Debré, Louis Pasteur, trans. Elborg Forster (1994), 169.
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As in Mathematicks, so in Natural Philosophy, the Investigation of difficult Things by the Method of Analysis, ought ever to precede the Method of Composition. This Analysis consists in making Experiments and Observations, and in drawing general Conclusions from them by Induction, and admitting of no Objections against the Conclusions, but such as are taken from Experiments, or other certain Truths. For Hypotheses are not to be regarded in experimental Philosophy.
Opticks, 2nd edition (1718), Book 3, Query 31, 380.
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As in the experimental sciences, truth cannot be distinguished from error as long as firm principles have not been established through the rigorous observation of facts.
Ésur la maladie des vers ásoie (1870), 39.
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As there is not in human observation proper means for measuring the waste of land upon the globe, it is hence inferred, that we cannot estimate the duration of what we see at present, nor calculate the period at which it had begun; so that, with respect to human observation, this world has neither a beginning nor an end.
Abstract of a Dissertation... Concerning the System of the Earth, its Duration, and Stability (1785), 28.
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Astronomers and physicists, dealing habitually with objects and quantities far beyond the reach of the senses, even with the aid of the most powerful aids that ingenuity has been able to devise, tend almost inevitably to fall into the ways of thinking of men dealing with objects and quantities that do not exist at all, e.g., theologians and metaphysicians. Thus their speculations tend almost inevitably to depart from the field of true science, which is that of precise observation, and to become mere soaring in the empyrean. The process works backward, too. That is to say, their reports of what they pretend actually to see are often very unreliable. It is thus no wonder that, of all men of science, they are the most given to flirting with theology. Nor is it remarkable that, in the popular belief, most astronomers end by losing their minds.
Minority Report: H. L. Mencken's Notebooks (1956), Sample 74, 60.
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Astronomy may be revolutionized more than any other field of science by observations from above the atmosphere. Study of the planets, the Sun, the stars, and the rarified matter in space should all be profoundly influenced by measurements from balloons, rockets, probes and satellites. ... In a new adventure of discovery no one can foretell what will be found, and it is probably safe to predict that the most important new discovery that will be made with flying telescopes will be quite unexpected and unforeseen. (1961)
Opening and closing of 'Flying Telescopes', Bulletin of the Atomic Scientists (May 1961), Vol. 17, No. 5, 191 and 194.
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At the beginning of its existence as a science, biology was forced to take cognizance of the seemingly boundless variety of living things, for no exact study of life phenomena was possible until the apparent chaos of the distinct kinds of organisms had been reduced to a rational system. Systematics and morphology, two predominantly descriptive and observational disciplines, took precedence among biological sciences during the eighteenth and nineteenth centuries. More recently physiology has come to the foreground, accompanied by the introduction of quantitative methods and by a shift from the observationalism of the past to a predominance of experimentation.
In Genetics and the Origin of Species (1937, 1982), 6.
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At this stage you must admit that whatever is seen to be sentient is nevertheless composed of atoms that are insentient. The phenomena open to our observation so not contradict this conclusion or conflict with it. Rather they lead us by the hand and compel us to believe that the animate is born, as I maintain, of the insentient.
In On the Nature of the Universe, translated by R. E. Latham (1951, 1994), 59.
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Birds ... are sensitive indicators of the environment, a sort of “ecological litmus paper,” ... The observation and recording of bird populations over time lead inevitably to environmental awareness and can signal impending changes.
In Peterson Field Guide to Birds of North America (2008), 10.
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But by far the greatest hindrance and aberration of the human understanding proceeds from the dullness, incompetency, and deceptions of the senses; in that things which strike the sense outweigh things which do not immediately strike it, though they be more important. Hence it is that speculation commonly ceases where sight ceases; insomuch that of things invisible there is little or no observation.
Aphorism 50,' Novum Organum, Book I (1620)
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By no amount of reasoning can we altogether eliminate all contingency from our world. Moreover, pure speculation alone will not enable us to get a determinate picture of the existing world. We must eliminate some of the conflicting possibilities, and this can be brought about only by experiment and observation.
Reason and Nature: an Essay on the Meaning of Scientific Method? (2nd Ed., 1964), 82.
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Chemistry is one of those branches of human knowledge which has built itself upon methods and instruments by which truth can presumably be determined. It has survived and grown because all its precepts and principles can be re-tested at any time and anywhere. So long as it remained the mysterious alchemy by which a few devotees, by devious and dubious means, presumed to change baser metals into gold, it did not flourish, but when it dealt with the fact that 56 g. of fine iron, when heated with 32 g. of flowers of sulfur, generated extra heat and gave exactly 88 g. of an entirely new substance, then additional steps could be taken by anyone. Scientific research in chemistry, since the birth of the balance and the thermometer, has been a steady growth of test and observation. It has disclosed a finite number of elementary reagents composing an infinite universe, and it is devoted to their inter-reaction for the benefit of mankind.
Address upon receiving the Perkin Medal Award, 'The Big Things in Chemistry', The Journal of Industrial and Engineering Chemistry (Feb 1921), 13, No. 2, 163.
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Chemists have made of phlogiston a vague principle which is not at all rigorously defined, and which, in consequence, adapts itself to all explanations in which it is wished it shall enter; sometimes it is free fire, sometimes it is fire combined with the earthy element; sometimes it passes through the pores of vessels, sometimes they are impenetrable to it; it explains both the causticity and non-causticity, transparency and opacity, colours and absence of colours. It is a veritable Proteus which changes its form every instant. It is time to conduct chemistry to a more rigorous mode of reasoning ... to distinguish fact and observation from what is systematic and hypothetical.
'Réflexions sur le phlogistique', Mémoires de l'Académie des Sciences, 1783, 505-38. Reprinted in Oeuvres de Lavoisier (1864), Vol. 2, 640, trans. M. P. Crosland.
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Common sense is science exactly in so far as it fulfills the ideal of common sense; that is, sees facts as they are, or at any rate, without the distortion of prejudice, and reasons from them in accordance with the dictates of sound judgment. And science is simply common sense at its best, that is, rigidly accurate in observation, and merciless to fallacy in logic.
The Crayfish: an Introduction to the Study of Zoölogy (1880), 2. Excerpted in Popular Science (Apr 1880), 16, 789.
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Computers and rocket ships are examples of invention, not of understanding. ... All that is needed to build machines is the knowledge that when one thing happens, another thing happens as a result. It's an accumulation of simple patterns. A dog can learn patterns. There is no “why&rdqo; in those examples. We don't understand why electricity travels. We don't know why light travels at a constant speed forever. All we can do is observe and record patterns.
In God's Debris: A Thought Experiment (2004), 22.
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Copernicus, the most learned man whom we are able to name other than Atlas and Ptolemy, even though he taught in a most learned manner the demonstrations and causes of motion based on observation, nevertheless fled from the job of constructing tables, so that if anyone computes from his tables, the computation is not even in agreement with his observations on which the foundation of the work rests. Therefore first I have compared the observations of Copernicus with those of Ptolemy and others as to which are the most accurate, but besides the bare observations, I have taken from Copernicus nothing other than traces of demonstrations. As for the tables of mean motion, and of prosthaphaereses and all the rest, I have constructed these anew, following absolutely no other reasoning than that which I have judged to be of maximum harmony.
Dedication to the Duke of Prussia, Prutenicae Tabulae (1551), 1585 edition, as quoted in Owen Gingerich, The Eye of Heaven: Ptolemy, Copernicus, Kepler (1993), 227.
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Cosmology is a science which has only a few observable facts to work with. The discovery of the cosmic microwave background radiation added one—the present radiation temperature of the universe. This, however, was a significant increase in our knowledge since it requires a cosmology with a source for the radiation at an early epoch and is a new probe of that epoch. More sensitive measurements of the background radiation in the future will allow us to discover additional facts about the universe.
'Discovery of the Cosmic Microwave Background', in B. Bertotti (ed.) Modern Cosmology in Retrospect (1990), 304.
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Cosmology, for centuries consisting of speculation based on a minimum of observational evidence and a maximum of philosophical predilection, became in the twentieth century an observational science, its theories now subject to verification or refutation to a degree previously unimaginable.
Opening sentence in 'Philosophical Values and Observation in Edwin Hubble's Choice of a Model of the Universe', Historical Studies in the Physical Sciences (1982), 13, No. 1, 41.
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During the last two centuries and a half, physical knowledge has been gradually made to rest upon a basis which it had not before. It has become mathematical. The question now is, not whether this or that hypothesis is better or worse to the pure thought, but whether it accords with observed phenomena in those consequences which can be shown necessarily to follow from it, if it be true
In Augustus De Morgan and Sophia Elizabeth De Morgan (ed.), A Budget of Paradoxes (1872), 2.
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Eratosthenes declares that it is no longer necessary to inquire as to the cause of the overflow of the Nile, since we know definitely that men have come to the sources of the Nile and have observed the rains there.
Proclus on Plato Timaeus, Vol. 1, 121.8-11 (Diehl). Quoted in Morris R. Cohen and I. E. Drabkin, A Sourcebook in Greek Science (1948), 383.
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Error, never can be consistent, nor can truth fail of having support from the accurate examination of every circumstance.
'Theory of the Earth', Transactions of the Royal Society of Edinburgh (1788), 1, 259.
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Even one well-made observation will be enough in many cases, just as one well-constructed experiment often suffices for the establishment of a law.
The Rules of Sociological Method (1895), 8th edition, trans. Sarah A. Solovay and John M. Mueller, ed. George E. G. Catlin (1938,1964 edition), 80.
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Every occurrence in Nature is preceded by other occurrences which are its causes, and succeeded by others which are its effects. The human mind is not satisfied with observing and studying any natural occurrence alone, but takes pleasure in connecting every natural fact with what has gone before it, and with what is to come after it.
In Forms of Water in Clouds and Rivers, Ice and Glaciers (1872), 1.
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Exercising the right of occasional suppression and slight modification, it is truly absurd to see how plastic a limited number of observations become, in the hands of men with preconceived ideas.
Meteorographica (1863), 5.
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Exper. I. I made a small hole in a window-shutter, and covered it with a piece of thick paper, which I perforated with a fine needle. For greater convenience of observation I placed a small looking-glass without the window-shutter, in such a position as to reflect the sun's light, in a direction nearly horizontal, upon the opposite wall, and to cause the cone of diverging light to pass over a table on which were several little screens of card-paper. I brought into the sunbeam a slip of card, about one-thirtieth of an inch in breadth, and observed its shadow, either on the wall or on other cards held at different distances. Besides the fringes of colour on each side of the shadow, the shadow itself was divided by similar parallel fringes, of smaller dimensions, differing in number, according to the distance at which the shadow was observed, but leaving the middle of the shadow always white. Now these fringes were the joint effects of the portions of light passing on each side of the slip of card and inflected, or rather diffracted, into the shadow. For, a little screen being placed a few inches from the card, so as to receive either edge of the shadow on its margin, all the fringes which had before been observed in the shadow on the wall, immediately disappeared, although the light inflected on the other side was allowed to retain its course, and although this light must have undergone any modification that the proximity of the other edge of the slip of card might have been capable of occasioning... Nor was it for want of a sufficient intensity of light that one of the two portions was incapable of producing the fringes alone; for when they were both uninterrupted, the lines appeared, even if the intensity was reduced to one-tenth or one-twentieth.
'Experiments and Calculations Relative to Physical Optics' (read in 1803), Philosophical Transactions (1804), 94, 2-3.
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Experiments in geology are far more difficult than in physics and chemistry because of the greater size of the objects, commonly outside our laboratories, up to the earth itself, and also because of the fact that the geologic time scale exceeds the human time scale by a million and more times. This difference in time allows only direct observations of the actual geologic processes, the mind having to imagine what could possibly have happened in the past.
In 'The Scientific Character of Geology', The Journal of Geology (Jul 1961), 69, No. 4, 455-6.
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Eyes and ears are bad witnesses for men who have barbarian souls.
Heraclitus, fr. 107. Trans. R. W. Sharples.

Far from becoming discouraged, the philosopher should applaud nature, even when she appears miserly of herself or overly mysterious, and should feel pleased that as he lifts one part of her veil, she allows him to glimpse an immense number of other objects, all worthy of investigation. For what we already know should allow us to judge of what we will be able to know; the human mind has no frontiers, it extends proportionately as the universe displays itself; man, then, can and must attempt all, and he needs only time in order to know all. By multiplying his observations, he could even see and foresee all phenomena, all of nature's occurrences, with as much truth and certainty as if he were deducing them directly from causes. And what more excusable or even more noble enthusiasm could there be than that of believing man capable of recognizing all the powers, and discovering through his investigations all the secrets, of nature!
'Des Mulets', Oeuvres Philosophiques, ed. Jean Piveteau (1954), 414. Quoted in Jacques Roger, The Life Sciences in Eighteenth-Century French Thought, ed. Keith R. Benson and trans. Robert Ellrich (1997), 458.
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For the holy Bible and the phenomena of nature proceed alike from the divine Word, the former as the dictate of the Holy Ghost and the latter as the observant executrix of God's commands. It is necessary for the Bible, in order to be accommodated to the understanding of every man, to speak many things which appear to differ from the absolute truth so far as the bare meaning of the words is concerned. But Nature, on the other hand, is inexorable and immutable; she never transgresses the laws imposed upon her, or cares a whit whether her abstruse reasons and methods of operation are understandable to men. For that reason it appears that nothing physical which sense-experience sets before our eyes, or which necessary demonstrations prove to us, ought to be called in question (much less condemned) upon the testimony of biblical passages which may have some different meaning beneath their words.
Letter to Madame Christina of Lorraine, Grand Duchess of Tuscany: Concerning the Use of Biblical Quotations in Matters of Science (1615), trans. Stillman Drake, Discoveries and Opinions of Galileo (1957), 182-3.
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For the little that one has reflected on the origin of our knowledge, it is easy to perceive that we can acquire it only by means of comparison. That which is absolutely incomparable is wholly incomprehensible. God is the only example that we could give here. He cannot be comprehended, because he cannot be compared. But all which is susceptible of comparison, everything that we can perceive by different aspects, all that we can consider relatively, can always be judged according to our knowledge.
'Histoire naturelle de l'Homme', Histoire Naturelle, Générale et Particuličre, Avec la Description du Cabinet du Roi (1749), Vol. 2, 431. Trans. Phillip R. Sloan.
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For there are two modes of acquiring knowledge, namely, by reasoning and experience. Reasoning draws a conclusion and makes us grant the conclusion, but does not make the conclusion certain, nor does it remove doubt so that the mind may rest on the intuition of truth, unless the mind discovers it by the path of experience; since many have the arguments relating to what can be known, but because they lack experience they neglect the arguments, and neither avoid what is harmful nor follow what is good. For if a man who has never seen fire should prove by adequate reasoning that fire burns and injures things and destroys them, his mind would not be satisfied thereby, nor would he avoid fire, until he placed his hand or some combustible substance in the fire, so that he might prove by experience that which reasoning taught. But when he has had actual experience of combustion his mind is made certain and rests in the full light of truth. Therefore reasoning does not suffice, but experience does.
Opus Majus [1266-1268], Part VI, chapter I, trans. R. B. Burke, The Opus Majus of Roger Bacon (1928), Vol. 2, 583.
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For those [observations] that I made in Leipzig in my youth and up to my 21st year, I usually call childish and of doubtful value. Those that I took later until my 28th year [i.e., until 1574] I call juvenile and fairly serviceable. The third group, however, which I made at Uraniborg during approximately the last 21 years with the greatest care and with very accurate instruments at a more mature age, until I was fifty years of age, those I call the observations of my manhood, completely valid and absolutely certain, and this is my opinion of them.
H. Raeder, E. and B. Stromgren (eds. and trans.), Tycho Brahe's Description of his Instruments and Scientific Work: as given in Astronomiae Instauratae Mechanica, Wandesburgi 1598 (1946), 110.

From his observations, he concluded that it [Tycho's supernova] was not some kind of comet or a fiery meteor, whether these be generated beneath the Moon or above the Moon, but that it is a star shining in the firmament itself - one that has never previously been seen before our time, in any age since the beginning of the world.
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From my close observation of writers ... they fall in to two groups: 1) those who bleed copiously and visibly at any bad review, and 2) those who bleed copiously and secretly at any bad review.
In Gold: The Final Science Fiction Collection? (2003).
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From my numerous observations, I conclude that these tubercle bacilli occur in all tuberculous disorders, and that they are distinguishable from all other microorganisms.
'The Etiology of Tuberculosis' (1882), Essays of Robert Koch (1987), trans. K. Codell Carter, 87.
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From whatever I have been able to observe up to this time the series of strata which form the visible crust of the earth appear to me classified in four general and successive orders. These four orders can be conceived to be four very large strata, as they really are, so that wherever they are exposed, they are disposed one above the other, always in the same order.
Quoted in Francesco Rodolico, 'Arduino', In Charles Coulston Gillispie (ed.), Dictionary of Scientific Biography (1970), Vol. 1, 234.
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Genius and science have burst the limits of space, and few observations, explained by just reasoning, have unveiled the mechanism of the universe. Would it not also be glorious for man to burst the limits of time, and, by a few observations, to ascertain the history of this world, and the series of events which preceded the birth of the human race?
'Preliminary discourse', to Recherches sur les Ossemens Fossiles (1812), trans. R. Kerr Essay on the Theory of the Earth (1813), 3-4.
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Geological facts being of an historical nature, all attempts to deduce a complete knowledge of them merely from their still, subsisting consequences, to the exclusion of unexceptionable testimony, must be deemed as absurd as that of deducing the history of ancient Rome solely from the medals or other monuments of antiquity it still exhibits, or the scattered ruins of its empire, to the exclusion of a Livy, a Sallust, or a Tacitus.
Geological Essays (1799), 5.
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Geology ... offers always some material for observation. ... [When] spring and summer come round, how easily may the hammer be buckled round the waist, and the student emerge from the dust of town into the joyous air of the country, for a few delightful hours among the rocks.
In The Story of a Boulder: or, Gleanings from the Note-book of a Field Geologist (1858), viii.
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Geology is part of that remarkable dynamic process of the human mind which is generally called science and to which man is driven by an inquisitive urge. By noticing relationships in the results of his observations, he attempts to order and to explain the infinite variety of phenomena that at first sight may appear to be chaotic. In the history of civilization this type of progressive scientist has been characterized by Prometheus stealing the heavenly fire, by Adam eating from the tree of knowledge, by the Faustian ache for wisdom.
In 'The Scientific Character of Geology', The Journal of Geology (Jul 1961), 69, No. 4, 454.
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Having always observed that most of them who constantly took in the weekly Bills of Mortality made little other use of them than to look at the foot how the burials increased or decreased, and among the Casualties what had happened, rare and extraordinary, in the week current; so as they might take the same as a Text to talk upon in the next company, and withal in the Plague-time, how the Sickness increased or decreased, that the Rich might judg of the necessity of their removal, and Trades-men might conjecture what doings they were likely to have in their respective dealings.
From Natural and Political Observations Mentioned in a Following Index and Made upon Bills of Mortality (1662), Preface. Reproduced in Cornelius Walford, The Insurance Cyclopaedia (1871), Vol. 1, 286. Italicizations from another source.
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History, human or geological, represents our hypothesis, couched in terms of past events, devised to explain our present-day observations.
'Critique of the Principle of Uniformity', in C. C. Albritton (ed.), Uniformity and Simplicity (1967), 30.
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I am a firm believer, that without speculation there is no good and original observation.
Letter to A. R. Wallace (22 Dec 1857). In Alfred Russel Wallace and Sir James Marchant (ed.), Alfred Russel Wallace: Letters and Reminiscences (1916), 109.
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I am convinced that this is the only means of advancing science, of clearing the mind from a confused heap of contradictory observations, that do but perplex and puzzle the Student, when he compares them, or misguide him if he gives himself up to their authority; but bringing them under one general head, can alone give rest and satisfaction to an inquisitive mind.
From 'A Discourse Delivered to the Students of the Royal Academy, on the Distribution of Prizes' (11 Dec 1770), in Seven Discourses Delivered in the Royal Academy (1778), 98.
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I am not accustomed to saying anything with certainty after only one or two observations.
Epistola, Rationem, Modumque Propinandi Radicis Chynae Decocti (Letter on the China Root) in Charles Donald O'Malley (trans.), Andreas Vesalius of Brussels, 1514-1564 (1965), 201.
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I am turned into a sort of machine for observing facts and grinding out conclusions.
As quoted in Adrian J. Desmond and James Richard Moore, Darwin (1994), 644. Described by the authors as a remark Darwin was heard to sigh, suspecting that his largest botany book, the 600-page Movement in Plants, was as dull as ditchwater.
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I believe in evidence. I believe in observation, measurement, and reasoning, confirmed by independent observers. I'll believe anything, no matter how wild and ridiculous, if there is evidence for it. The wilder and more ridiculous something is, however, the firmer and more solid the evidence will have to be.
In David S. Bradford, In the Beginning: Building the Temple of Zion? (2008).
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I belong to those theoreticians who know by direct observation what it means to make a measurement. Methinks it were better if there were more of them.
Referring to his laboratory experience during his assistantship in experimental physics, as quoted in Walter Moore, Schrödinger: Life and Thought (1989, 1998), 58-59. Moore describes that Schrödinger in his early days in the laboratory, “learned to believe that physics is not based upon mathematical fantasies but on a solid ground of experimental observations.”
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I cannot but be astonished that Sarsi should persist in trying to prove by means of witnesses something that I may see for myself at any time by means of experiment. Witnesses are examined in doutbful matters which are past and transient, not in those which are actual and present. A judge must seek by means of witnesses to determine whether Peter injured John last night, but not whether John was injured, since the judge can see that for himself.
'The Assayer' (1623), trans. Stillman Drake, Discoveries and Opinions of Galileo (1957), 271.
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I could not help laughing at the ease with which he explained his process of deduction. “When I hear you give your reasons,” I remarked, “the thing always appears to me to be so ridiculously simple that I could easily do it myself, though at each successive instance of your reasoning I am baffled, until you explain your process. And yet I believe that my eyes are as good as yours.”
“Quite so,” he answered, lighting a cigarette, and throwing himself down into an arm-chair. “You see, but you do not observe. The distinction is clear. For example, you have frequently seen the steps which lead up from the hall to this room.”
“Frequently.”
“How often?”
“'Well, some hundreds of times.”
“Then how many are there?”
“How many! I don't know.”
“Quite so! You have not observed. And yet you have seen. That is just my point. Now, I know that there seventeen steps, because I have both seen and observed.”
From 'Adventure I.—A Scandal in Bohemia', Adventures of Sherlock Holmes, in The Strand Magazine: An Illustrated Monthly (Jul 1891), Vol. 2, 62.

I have always loved to begin with the facts, to observe them, to walk in the light of experiment and demonstrate as much as possible, and to discuss the results.
Quoted in Francesco Rodolico, 'Arduino', In Charles Coulston Gillispie (ed.), Dictionary of Scientific Biography (1970), Vol. 1, 234.
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I picture the vast realm of the sciences as an immense landscape scattered with patches of dark and light. The goal towards which we must work is either to extend the boundaries of the patches of light, or to increase their number. One of these tasks falls to the creative genius; the other requires a sort of sagacity combined with perfectionism.
Thoughts on the Interpretation of Nature and Other Philosophical Works (1753/4), ed. D. Adams (1999), Section XIV, 42.
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I really see no harm which can come of giving our children a little knowledge of physiology. ... The instruction must be real, based upon observation, eked out by good explanatory diagrams and models, and conveyed by a teacher whose own knowledge has been acquired by a study of the facts; and not the mere catechismal parrot-work which too often usurps the place of elementary teaching.
Science and Culture (1882), 92.
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I shall collect plants and fossils, and with the best of instruments make astronomic observations. Yet this is not the main purpose of my journey. I shall endeavor to find out how nature's forces act upon one another, and in what manner the geographic environment exerts its influence on animals and plants. In short, I must find out about the harmony in nature.
Letter to Karl Freiesleben (Jun 1799). In Helmut de Terra, Humboldt: The Life and Times of Alexander van Humboldt 1769-1859 (1955), 87.
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I therefore concluded, and decided unhesitatingly, that there are three stars in the heavens moving about Jupiter, as Venus and Mercury about the Sun; which at length was established as clear as daylight by numerous other observations.
Referring to his pioneering telescope observations.
The Starry Messenger (Mar 1610). Quoted in Edmund Blair Bolles, Galileo's Commandment (1999), 104.
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I think that the event which, more than anything else, led me to the search for ways of making more powerful radio telescopes, was the recognition, in 1952, that the intense source in the constellation of Cygnus was a distant galaxy—1000 million light years away. This discovery showed that some galaxies were capable of producing radio emission about a million times more intense than that from our own Galaxy or the Andromeda nebula, and the mechanisms responsible were quite unknown. ... [T]he possibilities were so exciting even in 1952 that my colleagues and I set about the task of designing instruments capable of extending the observations to weaker and weaker sources, and of exploring their internal structure.
From Nobel Lecture (12 Dec 1974). In Stig Lundqvist (ed.), Nobel Lectures, Physics 1971-1980 (1992), 187.
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I would by all means have men beware, lest Æsop's pretty fable of the fly that sate [sic] on the pole of a chariot at the Olympic races and said, 'What a dust do I raise,' be verified in them. For so it is that some small observation, and that disturbed sometimes by the instrument, sometimes by the eye, sometimes by the calculation, and which may be owing to some real change in the heaven, raises new heavens and new spheres and circles.
'Of Vain Glory' (1625) in James Spedding, Robert Ellis and Douglas Heath (eds.), The Works of Francis Bacon (1887-1901), Vol. 6, 503.
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I'm not smart. I try to observe. Millions saw the apple fall but Newton was the one who asked 'why.'
Quoted in New York Post (24 Jun 1965). In Alfred J. Kolatch, Great Jewish Quotations (1996), 38-39.
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If someone points out to you that your pet theory of the universe is in disagreement with Maxwell’s equations—then so much the worse for Maxwell’s equations. If it is found to be contradicted by observation—well these experimentalists do bungle things sometimes. But if your theory is found to be against the second law of thermodynamics I can give you no hope; there is nothing for it but to collapse in deepest humiliation.
Gifford Lectures (1927), The Nature of the Physical World (1928), 74.
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If the Commission is to enquire into the conditions “to be observed,” it is to be presumed that they will give the result of their enquiries; or, in other words, that they will lay down, or at least suggest, “rules” and “conditions to be (hereafter) observed” in the construction of bridges, or, in other words, embarrass and shackle the progress of improvement to-morrow by recording and registering as law the prejudices or errors of to-day.
[Objecting to any interference by the State with the freedom of civil engineers in the conduct of their professional work.]
Letter (13 Mar 1848) to the Royal Commission on the Application of Iron in Railway Structures. Collected in The Life of Isambard Kingdom Brunel, Civil Engineer (1870), 487. The above verbatim quote may be the original source of the following statement as seen in books and on the web without citation: “I am opposed to the laying down of rules or conditions to be observed in the construction of bridges lest the progress of improvement tomorrow might be embarrassed or shackled by recording or registering as law the prejudices or errors of today.” Webmaster has not yet found a primary source for his latter form, and suspects it may be a synopsis, rather than a verbatim quote. If you know of such a primary source, please inform Webmaster.
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If the matter is one that can be settled by observation, make the observation yourself. Aristotle could have avoided the mistake of thinking that women have fewer teeth than men, by the simple device of asking Mrs. Aristotle to keep her mouth open while he counted.
In An Outline of Intellectual Rubbish (1943), 22.
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If the omniscient author of nature knew that the study of his works tends to make men disbelieve his Being or Attributes, he would not have given them so many invitations to study and contemplate Nature.
'Some considerations touching the usefulness of experimental philosophy' (1663). Quoted In Peter Gay, The Enlightenment (1977), 140.
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If we range through the whole territory of nature, and endeavour to extract from each department the rich stores of knowledge and pleasure they respectively contain, we shall not find a more refined or purer source of amusement, or a more interesting and unfailing subject for recreation, than that which the observation and examination of the structure, affinities, and habits of plants and vegetables, afford.
In A Practical Treatise on the Cultivation of the Dahlia (1838), 2.
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In all speculations on the origin, or agents that have produced the changes on this globe, it is probable that we ought to keep within the boundaries of the probable effects resulting from the regular operations of the great laws of nature which our experience and observation have brought within the sphere of our knowledge. When we overleap those limits, and suppose a total change in nature's laws, we embark on the sea of uncertainty, where one conjecture is perhaps as probable as another; for none of them can have any support, or derive any authority from the practical facts wherewith our experience has brought us acquainted.
Observations on the Geology of the United States of America (1817), iv-v.
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In fact, we will have to give up taking things for granted, even the apparently simple things. We have to learn to understand nature and not merely to observe it and endure what it imposes on us. Stupidity, from being an amiable individual defect, has become a social crime.
The Origin of Life (1967), 163.

In natural science the principles of truth ought to be confirmed by observation.
Philosophia Botanica (1751), final sentence. Trans. Frans A. Stafleu, Linnaeus and the Linneans: The Spreading of their Ideas in Systematic Botany, 1735-1789 (1971), 31.
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In order that the facts obtained by observation and experiment may be capable of being used in furtherance of our exact and solid knowledge, they must be apprehended and analysed according to some Conceptions which, applied for this purpose, give distinct and definite results, such as can be steadily taken hold of and reasoned from.
Philosophy of the Inductive Sciences (1840), Vol. 2, 205.
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In the beginning there were only probabilities. The universe could only come into existence if someone observed it. It does not matter that the observers turned up several billion years later. The universe exists because we are aware of it.
In 'The Anthropic Universe', New Scientist (6 Aug 1987), 46.
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In the collecting of evidence upon any medical subject, there are but three sources from which we can hope to obtain it: viz. from observation of the living subject; from examination of the dead; and from experiments upon living animals.
Astley Cooper and Benjamin Travers, Surgical Essays (1821), Vol. 1, 84. In Ira M. Rutkow, The History of Surgery in the United States, 1775-1900 (1988), 394.
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In the great debates of early-nineteenth century geology, catastrophists followed the stereotypical method of objective science-empirical literalism. They believed what they saw, interpolated nothing, and read the record of the rocks directly.
'The Stinkstones of Oeningen', In Hen's Teeth and Horse's Toes (1983), 105.

In the philosophic sense, observation shows and experiment teaches.
An Introduction to the Study of Experimental Medicine (1865), trans. Henry Copley Green (1957), 5.
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In the printed page the only real things are the paper and the ink; the white spaces play the same part in aiding the eye to take in the meaning of the print as do the black letters.
From Under the Apple-Trees (1916), 302.
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In the school of political projectors, I was but ill entertained, the professors appearing, in my judgment, wholly out of their senses; which is a scene that never fails to make me melancholy. These unhappy people were proposing schemes for persuading monarchs to choose favourites upon the score of their wisdom, capacity, and virtue; of teaching ministers to consult the public good; of rewarding merit, great abilities, and eminent services; of instructing princes to know their true interest, by placing it on the same foundation with that of their people; of choosing for employment persons qualified to exercise them; with many other wild impossible chimeras, that never entered before into the heart of man to conceive, and confirmed in me the old observation, that there is nothing so extravagant and irrational which some philosophers have not maintained for truth.
Gulliver's Travels (1726, Penguin ed. 1967), Part III, Chap. 6, 232.
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It appears, then, to be a condition of a genuinely scientific hypothesis, that it be not destined always to remain an hypothesis, but be certain to be either proved or disproved by.. .comparison with observed facts.
A System of Logic, Ratiocinative and Inductive (1858), 293.
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It is a common observation that a science first begins to be exact when it is quantitatively treated. What are called the exact sciences are no others than the mathematical ones.
On The Doctrine of Chances, with Later Reflections (1878), 61.
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It is a misfortune for a science to be born too late when the means of observation have become too perfect. That is what is happening at this moment with respect to physical chemistry; the founders are hampered in their general grasp by third and fourth decimal places.
Science and Hypothesis (1902), trans. W. J. G. and preface by J. Larmor (1905), 181.
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It is imperative in the design process to have a full and complete understanding of how failure is being obviated in order to achieve success. Without fully appreciating how close to failing a new design is, its own designer may not fully understand how and why a design works. A new design may prove to be successful because it has a sufficiently large factor of safety (which, of course, has often rightly been called a “factor of ignorance”), but a design's true factor of safety can never be known if the ultimate failure mode is unknown. Thus the design that succeeds (ie, does not fail) can actually provide less reliable information about how or how not to extrapolate from that design than one that fails. It is this observation that has long motivated reflective designers to study failures even more assiduously than successes.
In Design Paradigms: Case Histories of Error and Judgment in Engineering (1994), 31. books.google.comHenry Petroski - 1994
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It is indeed an Opinion strangely prevailing amongst Men, that Houses, Mountains, Rivers, and in a word all sensible Objects have an Existence Natural or Real, distinct from their being perceived by the Understanding. But with how great an Assurance and Acquiescence soever this Principle may be entertained in the World; yet whoever shall find in his Heart to call it in Question, may, if I mistake not, perceive it to involve a manifest Contradiction. For what are the forementioned Objects but the things we perceive by Sense, and what do we perceive besides our own Ideas or Sensations; and is it not plainly repugnant that anyone of these or any Combination of them should exist unperceived?
A Treatise Concerning the Principles of Human Knowledge [first published 1710], (1734),38.
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It is not therefore the business of philosophy, in our present situation in the universe, to attempt to take in at once, in one view, the whole scheme of nature; but to extend, with great care and circumspection, our knowledge, by just steps, from sensible things, as far as our observations or reasonings from them will carry us, in our enquiries concerning either the greater motions and operations of nature, or her more subtile and hidden works. In this way Sir Isaac Newton proceeded in his discoveries.
An Account of Sir Isaac Newton's Philosophical Discoveries, in Four Books (1748), 19.
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It is structure that we look for whenever we try to understand anything. All science is built upon this search; we investigate how the cell is built of reticular material, cytoplasm, chromosomes; how crystals aggregate; how atoms are fastened together; how electrons constitute a chemical bond between atoms. We like to understand, and to explain, observed facts in terms of structure. A chemist who understands why a diamond has certain properties, or why nylon or hemoglobin have other properties, because of the different ways their atoms are arranged, may ask questions that a geologist would not think of' formulating, unless he had been similarly trained in this way of thinking about the world.
‘The Place of Chemistry In the Integration of the Sciences’, Main Currents in Modern Thought (1950), 7, 110.
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It is usual to say that the two sources of experience are Observation and Experiment. When we merely note and record the phenomena which occur around us in the ordinary course of nature we are said to observe. When we change the course of nature by the intervention of our will and muscular powers, and thus produce unusual combinations and conditions of phenomena, we are said to experiment. [Sir John] Herschel has justly remarked that we might properly call these two modes of experience passive and active observation. In both cases we must certainly employ our senses to observe, and an experiment differs from a mere observation in the fact that we more or less influence the character of the events which we observe. Experiment is thus observation plus alteration of conditions.
Principles of Science: A Treatise on Logic and Scientific Method (1874, 2nd ed., 1913), 400.
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It must be admitted that science has its castes. The man whose chief apparatus is the differential equation looks down upon one who uses a galvanometer, and he in turn upon those who putter about with sticky and smelly things in test tubes. But all of these, and most biologists too, join together in their contempt for the pariah who, not through a glass darkly, but with keen unaided vision, observes the massing of a thundercloud on the horizon, the petal as it unfolds, or the swarming of a hive of bees. And yet sometimes I think that our laboratories are but little earthworks which men build about themselves, and whose puny tops too often conceal from view the Olympian heights; that we who work in these laboratories are but skilled artisans compared with the man who is able to observe, and to draw accurate deductions from the world about him.
The Anatomy of Science (1926), 170- 1.
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It seems sensible to discard all hope of observing hitherto unobservable quantities, such as the position and period of the electron... Instead it seems more reasonable to try to establish a theoretical quantum mechanics, analogous to classical mechanics, but in which only relations between observable quantities occur.
In Helge Kragh, Quantum Generations: A History of Physics in the Twentieth Century (1999), 161.
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It was astonishing that for some considerable distance around the mould growth the staphococcal colonies were undergoing lysis. What had formerly been a well-grown colony was now a faint shadow of its former self...I was sufficiently interested to pursue the subject.
[Sep 1928, the first observation of penicillin. Lysis is the dissolution or destruction of cells.]
Sarah R. Riedman and Elton T. Gustafson, Portraits of Nobel Laureates in Medicine and Physiology (1964), 72.
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It was noted long ago that the front row of burlesque houses was occupied predominantly by bald-headed men. In fact, such a row became known as the bald-headed row. It might be assumed from this on statistical evidence that the continued close observation of chorus girls in tights caused loss of hair from the top of the head.
[Disputing a statistical study for the American Cancer Society showing smoking to be a cancer causative.]
In Bess Furman, '2 Cite Extraction of Cigarette Tar', New York Times (26 Jul 1957), 21. The article reported on testimony before the Legal and Monetary Affairs Subcommittee of the House Government Operations Committee.
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It would appear... that moral phenomena, when observed on a great scale, are found to resemble physical phenomena; and we thus arrive, in inquiries of this kind, at the fundamental principle, that the greater the number of individuals observed, the more do individual peculiarities, whether physical or moral, become effaced, and leave in a prominent point of view the general facts, by virtue of which society exists and is preserved.
A Treatise on Man and the Development of his Faculties (1842). Reprinted with an introduction by Solomon Diamond (1969), 6.
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Let him who so wishes take pleasure in boring us with all the wonders of nature: let one spend his life observing insects, another counting the tiny bones in the hearing membrane of certain fish, even in measuring, if you will, how far a flea can jump, not to mention so many other wretched objects of study; for myself, who am curious only about philosophy, who am sorry only not to be able to extend its horizons, active nature will always be my sole point of view; I love to see it from afar, in its breadth and its entirety, and not in specifics or in little details, which, although to some extent necessary in all the sciences, are generally the mark of little genius among those who devote themselves to them.
'L'Homme Plante', in Oeuvres Philosophiques de La Mettrie (1796), Vol. 2, 70-1. Jacques Roger, The Life Sciences in Eighteenth-Century French Thought, edited by Keith R. Benson and trans. Robert Ellrich (1997), 377.
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Let people who have to observe sickness and death look back and try to register in their observation the appearances which have preceded relapse, attack or death, and not assert that there were none, or that there were not the right ones. A want of the habit of observing conditions and an inveterate habit of taking averages are each of them often equally misleading.
Notes on Nursing: What it is, and What it is Not (1860), 67.
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Let us then suppose the Mind to be, as we say, white Paper, void of all Characters, without any Ideas; How comes it to be furnished? Whence comes it by that vast store, which the busy and boundless Fancy of Man has painted on it, with an almost endless variety? Whence has it all the materials of Reason and Knowledge? To this I answer, in one word, from Experience: In that, all our Knowledge is founded; and from that it ultimately derives it self. Our Observation employ'd either about external, sensible Objects; or about the internal Operations of our Minds, perceived and reflected on by our selves, is that, which supplies our Understandings with all the materials of thinking.
An Essay Concerning Human Understanding (1690). Edited by Peter Nidditch (1975), Book 2, Chapter 1, Section 2, 104.
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Long before I ever saw the desert I was aware of the mystical overtones which the observation of nature made audible to me. But I have never been more frequently or more vividly aware of them than in connection with the desert phenomena.
The Voice of the Desert, a Naturalist's Interpretation (1955, 1975), 216.
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Magnitude may be compared to the power output in kilowatts of a [radio] broadcasting station; local intensity, on the Mercalli or similar scale, is then comparable to the signal strength noted on a receiver at a given locality. Intensity, like signal strength, will generally fall off with distance from the source; it will also depend on local conditions at the point of observation, and to some extent on the conditions along the path from source to that point.
From interview in the Earthquake Information Bulletin (Jul-Aug 1971), 3, No. 4, as abridged in article on USGS website.
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Man does not limit himself to seeing; he thinks and insists on learning the meaning of phenomena whose existence has been revealed to him by observation. So he reasons, compares facts, puts questions to them, and by the answers which he extracts, tests one by another. This sort of control, by means of reasoning and facts, is what constitutes experiment, properly speaking; and it is the only process that we have for teaching ourselves about the nature of things outside us.
In Claude Bernard and Henry Copley Greene (trans.), An Introduction to the Study of Experimental Medicine (1927, 1957), 5.
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Man, as the minister and interpreter of nature, is limited in act and understanding by his observation of the order of nature; neither his understanding nor his power extends further.
Novum Organum, Aphor I. Quoted in Robert Routledge, Discoveries and Inventions of the 19th Century (1890), 696

Man, being the servant and interpreter of Nature, can do and understand so much and so much only as he has observed in fact or thought of the course of nature; beyond this he neither knows anything nor can do anything.
The New Organon (1620) in James Spedding, Robert Ellis and Douglas Heath (eds.), The Works of Francis Bacon (1887-1901), Vol. 4, 47.
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Many 'hard' scientists regard the term 'social science' as an oxymoron. Science means hypotheses you can test, and prove or disprove. Social science is little more than observation putting on airs.
'A Cuba Policy That's Stuck On Plan A', opinion column, The Washington Post (17 Apr 2009)
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Mathematicians deal with possible worlds, with an infinite number of logically consistent systems. Observers explore the one particular world we inhabit. Between the two stands the theorist. He studies possible worlds but only those which are compatible with the information furnished by observers. In other words, theory attempts to segregate the minimum number of possible worlds which must include the actual world we inhabit. Then the observer, with new factual information, attempts to reduce the list further. And so it goes, observation and theory advancing together toward the common goal of science, knowledge of the structure and observation of the universe.
Lecture to Sigma Xi, 'The Problem of the Expanding Universe' (1941), printed in Sigma Xi Quarterly (1942), 30, 104-105. Reprinted in Smithsonian Institution Report of the Board of Regents (1943), 97, 123. As cited by Norriss S. Hetherington in 'Philosophical Values and Observation in Edwin Hubble's Choice of a Model of the Universe', Historical Studies in the Physical Sciences (1982), 13, No. 1, 63.
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Matters of fact, which as Mr Budgell somewhere observes, are very stubborn things.
In copy of the Will of Matthew Tindal (1733), 23. As cited in Kate Louise Roberts, Hoyt's New Cyclopedia of Practical Quotations (1922), 570.
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Medicine is an incoherent assemblage of incoherent ideas, and is, perhaps, of all the physiological Sciences, that which best shows the caprice of the human mind. What did I say! It is not a Science for a methodical mind. It is a shapeless assemblage of inaccurate ideas, of observations often puerile, of deceptive remedies, and of formulae as fantastically conceived as they are tediously arranged.
Bichat's General Anatomy, vol. 1, 17. Quoted in Alva Curtis, A Fair Examination and Criticism of All the Medical Systems in Vogue (1855), 1.
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More discoveries have arisen from intense observation of very limited material than from statistics applied to large groups. The value of the latter lies mainly in testing hypotheses arising from the former. While observing one should cultivate a speculative, contemplative attitude of mind and search for clues to be followed up. Training in observation follows the same principles as training in any activity. At first one must do things consciously and laboriously, but with practice the activities gradually become automatic and unconscious and a habit is established. Effective scientific observation also requires a good background, for only by being familiar with the usual can we notice something as being unusual or unexplained.
The Art of Scientific Investigation (1950), 101.
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My interest in science was excited at age nine by an article on astronomy in National Geographic; the author was Donald Menzel of the Harvard Observatory. For the next few years, I regularly made star maps and snuck out at night to make observations from a locust tree in our back yard.
In Wilhelm Odelberg (ed.), Les Prix Nobel. The Nobel Prizes 1986 (1987).
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Natural history is a matter of observation; it is a harvest which you gather when and where you find it growing. Birds and squirrels and flowers are not always in season, but philosophy we have always with us. It is a crop which we can grow and reap at all times and in all places and it has its own value and brings its own satisfaction.
From Under the Apple-Trees (1916), Preface.
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Nature, … in order to carry out the marvelous operations [that occur] in animals and plants has been pleased to construct their organized bodies with a very large number of machines, which are of necessity made up of extremely minute parts so shaped and situated as to form a marvelous organ, the structure and composition of which are usually invisible to the naked eye without the aid of a microscope. … Just as Nature deserves praise and admiration for making machines so small, so too the physician who observes them to the best of his ability is worthy of praise, not blame, for he must also correct and repair these machines as well as he can every time they get out of order.
'Reply to Doctor Sbaraglia in Opera Posthuma, 1697', in H. B. Adelmann (ed.), Marcello Malpighi and the Evolution of Embryology (1966), Vol. 1, 568.
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No other explanation of living forms is allowed than heredity, and any which is founded on another basis must be rejected. The present fashion requires that even the smallest and most indifferent inquiry must be dressed in phylogenetic costume, and whilst in former centuries authors professed to read in every natural detail some intention of the creator mundi, modern scientists have the aspiration to pick out from every occasional observation a fragment of the ancestral history of the living world.
'On the Principles of Animal Morphology', Proceedings of the Royal Society of Edinburgh (2 Apr 1888), 15, 294. Original as Letter to Mr John Murray, communicated to the Society by Professor Sir William Turner. Page given as in collected volume published 1889.
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No phenomenon is a physical phenomenon until it is an observed phenomenon.
Quoted in Robert J. Scully, The Demon and the Quantum (2007), 191.

Nor need you doubt that Pythagoras, a long time before he found the demonstration for the Hecatomb, had been certain that the square of the side subtending the right angle in a rectangular triangle was equal to the square of the other two sides; the certainty of the conclusion helped not a little in the search for a demonstration. But whatever was the method of Aristotle, and whether his arguing a priori preceded sense a posteriori, or the contrary, it is sufficient that the same Aristotle (as has often been said) put sensible experiences before all discourses. As to the arguments a priori, their force has already been examined.
Dialogue on the Great World Systems (1632). Revised and Annotated by Giorgio De Santillana (1953), 60.
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Nothing is known in our profession by guess; and I do not believe, that from the first dawn of medical science to the present moment, a single correct idea has ever emanated from conjecture: it is right therefore, that those who are studying their profession should be aware that there is no short road to knowledge; and that observation on the diseased living, examination of the dead, and experiments upon living animals, are the only sources of true knowledge; and that inductions from these are the sole bases of legitimate theory.
Astley Paston Cooper, Astley Cooper, Bransby Blake Cooper, A Treatise on Dislocations and Fractures of the Joints (1851), 155.
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Now having (I know not by what accident) engaged my thoughts upon the Bills of Mortality, and so far succeeded therein, as to have reduced several great confused Volumes into a few perspicuous Tables, and abridged such Observations as naturally flowed from them, into a few succinct Paragraphs, without any long Series of multiloquious Deductions, I have presumed to sacrifice these my small, but first publish'd, Labours unto your Lordship, as unto whose benign acceptance of some other of my Papers even the birth of these is due; hoping (if I may without vanity say it) they may be of as much use to persons in your Lordships place, as they are of none to me, which is no more than fairest Diamonds are to the Journeymen Jeweller that works them, or the poor Labourer that first digg'd them from Earth.
[An early account demonstrating the value of statistical analysis of public health data. Graunt lived in London at the time of the plague epidemics.]
From Graunt's 'Epistle Dedicatory', for Natural and Political Observations Mentioned in a Following Index and Made upon Bills of Mortality (1662). Reproduced in Cornelius Walford, The Insurance Cyclopaedia (1871), Vol. 1, 286. (This text used abbreviations for “Mort.” and “vols.”) The italicized words are given as from other sources. Note: bills of mortality are abstracts from parish registers showing the numbers that have died in each week, month or year.
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Now, I must tell you of a strange experience which bore fruit in my later life. ... We had a cold [snap] drier that ever observed before. People walking in the snow left a luminous trail behind them and a snowball thrown against an obstacle gave a flare of light like a loaf of sugar hit with a knife. [As I stroked] MaÄŤak's back, [it became] a sheet of light and my hand produced a shower of sparks. ... My father ... remarked, this is nothing but electricity, the same thing you see on the trees in a storm. My mother seemed alarmed. Stop playing with the cat, she said, he might start a fire. I was thinking abstractly. Is nature a cat? If so, who strokes its back? It can only be God, I concluded. ...
I cannot exaggerate the effect of this marvelous sight on my childish imagination. Day after day I asked myself what is electricity and found no answer. Eighty years have gone by since and I still ask the same question, unable to answer it.
Letter to Miss Pola Fotitch, 'A Story of Youth Told by Age' (1939). In John Ratzlaff, editor, Tesla Said (1984), 283-84. Cited in Marc J. Seifer, Wizard: The Life and Times of Nikola Tesla (1998), 5.
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Obervation is a passive science, experimentation is an active science.
In Fielding Hudson Garrison, An Introduction to the History of Medicine (1929), 15.
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Observation and experiment for gathering material, induction and deduction for elaborating it: these are are only good intellectual tools.
In Claude Bernard, Henry C. Greene and L. J. Henderson, An Introduction to the Study of Experimental Medicine (1957), 6.
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Observation by means of the microscope will reveal more wonderful things than those viewed in regard to mere structure and connection: for while the heart is still beating the contrary (i.e., in opposite directions in the different vessels) movement of the blood is observed in the vessels—though with difficulty—so that the circulation of the blood is clearly exposed.
De Pulmonibus (1661), trans. James Young, Proceedings of the Royal Society of Medicine (1929-30), 23, 8.
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Observation is like a piece of glass, which, as a mirror, must be very smooth, and must be very carefully polished, in order that it may reflect the image pure and undistorted.
'The Study of the Natural Sciences: An Introductory Lecture to the Course of Experimental Chemistry in the University of Munich, for the Winter Session of 1852-53,' as translated and republished in The Medical Times and Gazette (22 Jan 1853), N.S. Vol. 6, 82.
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Observation is so wide awake, and facts are being so rapidly added to the sum of human experience, that it appears as if the theorizer would always be in arrears, and were doomed forever to arrive at imperfect conclusion; but the power to perceive a law is equally rare in all ages of the world, and depends but little on the number of facts observed.
A Week on the Concord and Merrimack Rivers (1921), 270.
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Of course, if one ignores contradictory observations, one can claim to have an “elegant” or “robust” theory. But it isn't science.
In Science News (27 Jul 1991), 51. Excepted in Roy C. Martin, Astronomy on Trial: A Devastating and Complete Repudiation of the Big Bang Fiasco (1999), Appendix I, 217.
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Open up a few corpses: you will dissipate at once the darkness that observation alone could not dissipate.
Anatomie générale appliquée ŕ la physiologie ŕ la médecine (1801), avant-propos, xic.
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Our experience shows that not everything that is observable and measurable is predictable, no matter how complete our past observations may have been.
In Presidential Address (8 Feb 1963), Quarterly Journal of the Royal Astronomical Society (Mar 1963), 4, 197.
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Our model of Nature should not be like a building—a handsome structure for the populace to admire, until in the course of time some one takes away a corner stone and the edifice comes toppling down. It should be like an engine with movable parts. We need not fix the position of any one lever; that is to be adjusted from time to time as the latest observations indicate. The aim of the theorist is to know the train of wheels which the lever sets in motion—that binding of the parts which is the soul of the engine.
In 'The Internal Constitution of the Stars', The Scientific Monthly (Oct 1920), 11, No. 4, 302.
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Passing just lately over this lake, … and examining this water next day, I found floating therein divers earthy particles, and some green streaks, spirally wound serpent-wise, and orderly arranged, after the manner of the copper or tin worms, which distillers use to cool their liquors as they distil over. The whole circumference of each of these streaks was about the thickness of a hair of one's head. … all consisted of very small green globules joined together: and there were very many small green globules as well. [The earliest recorded observation of the common green alga Spyrogyra.]
Letter to the Royal Society, London (7 Sep 1674). In John Carey, Eyewitness to Science (1997), 28-29
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Reality is what kicks back when you kick it. This is just what physicists do with their particle accelerators. We kick reality and feel it kick back. From the intensity and duration of thousands of those kicks over many years, we have formed a coherent theory of matter and forces, called the standard model, that currently agrees with all observations.
In Has Science Found God?: The Latest Results in the Search for Purpose in the Universe (2003), 41.
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Round about the accredited and orderly facts of every science there ever floats a sort of dustcloud of exceptional observations, of occurrences minute and irregular and seldom met with, which it always proves more easy to ignore than to attend to.
The Fractal Geometry of Nature (1977), 28.
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Science emerges from the other progressive activities of man to the extent that new concepts arise from experiments and observations, and that the new concepts in turn lead to further experiments and observations.
as quoted by Marshall Bates in The Nature of Natural History (1950), p.4
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Science has to be understood in its broadest sense, as a method for apprehending all observable reality, and not merely as an instrument for acquiring specialized knowledge.
In Alfred Armand Montapert, Words of Wisdom to Live By: An Encyclopedia of Wisdom in Condensed Form (1986), 217, without citation. If you know the primary source, please contact Webmaster.
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Science is beautiful when it makes simple explanations of phenomena or connections between different observations. Examples include the double helix in biology, and the fundamental equations of physics.
[Answer to question: What are the things you find most beautiful in science?]
'Stephen Hawking: "There is no heaven; it's a fairy story"', interview in newspaper The Guardian (15 May 2011).
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Science is in a literal sense constructive of new facts. It has no fixed body of facts passively awaiting explanation, for successful theories allow the construction of new instruments—electron microscopes and deep space probes—and the exploration of phenomena that were beyond description—the behavior of transistors, recombinant DNA, and elementary particles, for example. This is a key point in the progressive nature of science—not only are there more elegant or accurate analyses of phenomena already known, but there is also extension of the range of phenomena that exist to be described and explained.
Co-author with Michael A. Arbib, English-born professor of computer science and biomedical engineering (1940-)
Michael A. Arbib and Mary B. Hesse, The Construction of Reality (1986), 8.
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Science quickens and cultivates directly the faculty of observation, which in very many persons lies almost dormant through life, the power of accurate and rapid generalizations, and the mental habit of method and arrangement; it accustoms young persons to trace the sequence of cause and effect; it familiarizes then with a kind of reasoning which interests them, and which they can promptly comprehend; and it is perhaps the best corrective for that indolence which is the vice of half-awakened minds, and which shrinks from any exertion that is not, like an effort of memory, merely mechanical.
Anonymous
Report of the Royal Commission on Education (1861), Parliamentary Papers (1864), Vol 20, 32-33, as cited in Paul White, Thomas Huxley: Making the "Man of Science" (2003), 77, footnote. Also quoted in John Lubbock, The Pleasures of Life (1887, 2007), 63.
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Science, then, is the attentive consideration of common experience; it is common knowledge extended and refined. Its validity is of the same order as that of ordinary perception; memory, and understanding. Its test is found, like theirs, in actual intuition, which sometimes consists in perception and sometimes in intent. The flight of science is merely longer from perception to perception, and its deduction more accurate of meaning from meaning and purpose from purpose. It generates in the mind, for each vulgar observation, a whole brood of suggestions, hypotheses, and inferences. The sciences bestow, as is right and fitting, infinite pains upon that experience which in their absence would drift by unchallenged or misunderstood. They take note, infer, and prophesy. They compare prophesy with event, and altogether they supply—so intent are they on reality—every imaginable background and extension for the present dream.
The Life of Reason, or the Phases of Human Progress (1954), 393.
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Scientific method, although in its more refined forms it may seem complicated, is in essence remarkably simply. It consists in observing such facts as will enable the observer to discover general laws governing facts of the kind in question. The two stages, first of observation, and second of inference to a law, are both essential, and each is susceptible of almost indefinite refinement. (1931)
In The Scientific Outlook (1931, 2009), 3.
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Scientific observation has established that education is not what the teacher gives; education is a natural process spontaneously carried out by the human individual, and is acquired not by listening to words but by experiences upon the environment. The task of the teacher becomes that of preparing a series of motives of cultural activity, spread over a specially prepared environment, and then refraining from obtrusive interference. Human teachers can only help the great work that is being done, as servants help the master. Doing so, they will be witnesses to the unfolding of the human soul and to the rising of a New Man who will not be a victim of events, but will have the clarity of vision to direct and shape the future of human society.
Education For a New World. Cited in Michael Olaf, Essential Montessori (1994), 112. In Millennial Child: Transforming Education in the Twenty-First Century (1999), 205.
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Scientists are convinced that they, as scientists, possess a number of very admirable human qualities, such as accuracy, observation, reasoning power, intellectual curiosity, tolerance, and even humility.
In Science is a Sacred Cow (1950), 15-16.
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Scientists can only carry on with their work, addressing legitimate questions as they arise and challenging misinformation. … Scientists work to fill the gaps in human knowledge and to build a theory that can explain observations of the world. Climate sceptics revel in such gaps, sometimes long after they have been filled.
Editorial, Nature (28 Jul 2011), 475, 423-424.
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Since science's competence extends to observable and measurable phenomena, not to the inner being of things, and to the means, not to the ends of human life, it would be nonsense to expect that the progress of science will provide men with a new type of metaphysics, ethics, or religion.
'Science and Ontology', Bulletin of Atomic Scientists (1949), 5, 200.
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Sir,—The Planet [Neptune] whose position you marked out actually exists. On the day on which your letter reached me, I found a star of the eighth magnitude, which was not recorded in the excellent map designed by Dr. Bremiker, containing the twenty-first hour of the collection published by the Royal Academy of Berlin. The observation of the succeeding day showed it to be the Planet of which we were in quest.
Letter, from Berlin (25 Sep 1846). In John Pringle Nichol, The Planet Neptune: An Exposition and History (1848), 89. Galle thus confirmed the existence of the planet Neptune, found at the position predicted in a letter he had just received from Urbain Le Verrier.
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Some months ago we discovered that certain light elements emit positrons under the action of alpha particles. Our latest experiments have shown a very striking fact: when an aluminium foil is irradiated on a polonium preparation [alpha ray emitter], the emission of positrons does not cease immediately when the active preparation is removed: the foil remains radioactive and the emission of radiation decays exponentially as for an ordinary radio-element. We observed the same phenomenon with boron and magnesium.
[Co-author with Irčne Joliot-Curie. This one-page paper reported their discovery of artificial radioactivity for which they were awarded the 1935 Nobel Prize for Chemistry.]
Letter to the Editor, 'Artificial Production of a New Kind of Radio-Element'(10 Jan 1934) published in Nature (1934), 133, 201-2. Cited in Mauro Dardo, Nobel Laureates and Twentieth-Century Physics (2004), 187.
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Some scientists find, or so it seems, that they get their best ideas when smoking; others by drinking coffee or whisky. Thus there is no reason why I should not admit that some may get their ideas by observing, or by repeating observations.
Realism and the Aim of Science (1983), 36.
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Speaking concretely, when we say 'making experiments or making observations,' we mean that we devote ourselves to investigation and to research, that we make attempts and trials in order to gain facts from which the mind, through reasoning, may draw knowledge or instruction.
Speaking in the abstract, when we say 'relying on observation and gaining experience,' we mean that observation is the mind's support in reasoning, and experience the mind's support in deciding, or still better, the fruit of exact reasoning applied to the interpretation of facts. It follows from this that we can gain experience without making experiments, solely by reasoning appropriately about well- established facts, just as we can make experiments and observations without gaining experience, if we limit ourselves to noting facts.
Observation, then, is what shows facts; experiment is what teaches about facts and gives experience in relation to anything. An Introduction to the Study of Experimental Medicine (1865), trans. Henry Copley Green (1957), 11.
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That a free, or at least an unsaturated acid usually exists in the stomachs of animals, and is in some manner connected with the important process of digestion, seems to have been the general opinion of physiologists till the time of SPALLANZANI. This illustrious philosopher concluded, from his numerous experiments, that the gastric fluids, when in a perfectly natural state, are neither acid nor alkaline. Even SPALLANZANI, however, admitted that the contents of the stomach are very generally acid; and this accords not only with my own observation, but with that, I believe, of almost every individual who has made any experiments on the subject. ... The object of the present communication is to show, that the acid in question is the muriatic [hydrochloric] acid, and that the salts usually met with in the stomach, are the alkaline muriates.
'On the Nature of the Acid and Saline Matters Usually Existing in the Stomachs of Animals', Philosophical Transactions of the Royal Society of London (1824), 114, 45-6.
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The air of caricature never fails to show itself in the products of reason applied relentlessly and without correction. The observation of clinical facts would seem to be a pursuit of the physician as harmless as it is indispensable. [But] it seemed irresistibly rational to certain minds that diseases should be as fully classifiable as are beetles and butterflies. This doctrine ... bore perhaps its richest fruit in the hands of Boissier de Sauvauges. In his Nosologia Methodica published in 1768 ... this Linnaeus of the bedside grouped diseases into ten classes, 295 genera, and 2400 species.
'General Ideas in Medicine', The Lloyd Roberts lecture at House of the Royal Society of Medicine (30 Sep 1935), British Medical Journal (5 Oct 1935), 2, 609. In The Collected Papers of Wilfred Trotter, FRS (1941), 151.
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The analysis of Nature into its individual parts, the grouping of the different natural processes and natural objects in definite classes, the study of the internal anatomy of organic bodies in their manifold forms—these were the fundamental conditions of the gigantic strides in our knowledge of Nature which have been made during the last four hundred years. But this method of investigation has also left us as a legacy the habit of observing natural objects and natural processes in their isolation, detached from the whole vast interconnection of things; and therefore not in their motion, but in their repose; not as essentially changing, but fixed constants; not in their life, but in their death.
Herr Eugen Dühring's Revolution in Science (Anti-Dühring), First Publication (1878). Trans. Emile Burns and ed. C. P. Dutt (1935), 27-8.
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The Big Idea that had been developed in the seventeenth century ... is now known as the scientific method. It says that the way to proceed when investigating how the world works is to first carry out experiments and/or make observations of the natural world. Then, develop hypotheses to explain these observations, and (crucially) use the hypothesis to make predictions about the future outcome of future experiments and/or observations. After comparing the results of those new observations with the predictions of the hypotheses, discard those hypotheses which make false predictions, and retain (at least, for the time being) any hypothesis that makes accurate predictions, elevating it to the status of a theory. Note that a theory can never be proved right. The best that can be said is that it has passed all the tests applied so far.
In The Fellowship: the Story of a Revolution (2005), 275.
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The business of their weekly Meetings shall be, To order, take account, consider, and discourse of Philosophical Experiments, and Observations: to read, hear, and discourse upon Letters, Reports, and other Papers containing Philosophical matters, as also to view, and discourse upon the productions and rarities of Nature, and Art: and to consider what to deduce from them, or how they may be improv'd for use, or discovery.
'An Abstract of the Statutes of the Royal Society', in Thomas Sprat, History of the Royal Society (1667), 145.
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The contents of this section will furnish a very striking illustration of the truth of a remark, which I have more than once made in my philosophical writings, and which can hardly be too often repeated, as it tends greatly to encourage philosophical investigations viz. That more is owing to what we call chance, that is, philosophically speaking, to the observation of events arising from unknown causes, than to any proper design, or pre-conceived theory in this business. This does not appear in the works of those who write synthetically upon these subjects; but would, I doubt not, appear very strikingly in those who are the most celebrated for their philosophical acumen, did they write analytically and ingenuously.
'On Dephlogisticated Air, and the Constitution of the Atmosphere', in The Discovery of Oxygen, Part I, Experiments by Joseph Priestley 1775 (Alembic Club Reprint, 1894), 5.
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The description of some of the experiments, which are communicated here, was completely worked out at my writing-table, before I had seen anything of the phenomena in question. After making the experiments on the following day, it was found that nothing in the description required to be altered. I do not mention this from feelings of pride, but in order to make clear the extraordinary ease and security with which the relations in question can be considered on the principles of Arrhenius' theory of free ions. Such facts speak more forcibly then any polemics for the value of this theory .
Philosophical Magazine (1891), 32, 156.
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The difference between myth and science is the difference between divine inspiration of 'unaided reason' (as Bertrand Russell put it) on the one hand and theories developed in observational contact with the real world on the other. It is the difference between the belief in prophets and critical thinking, between Credo quia absurdum (I believe because it is absurd–Tertullian) and De omnibus est dubitandum (Everything should be questioned–Descartes). To try to write a grand cosmical drama leads necessarily to myth. To try to let knowledge substitute ignorance in increasingly large regions of space and time is science.
In 'Cosmology: Myth or Science?'. Journal of Astrophysics and Astronomy (1984), 5, 79-98.
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The discrepancy between what was expected and what has been observed has grown over the years, and we're straining harder and harder to fill the gap.
[Commenting on the 1984 article in Nature discrediting neutrinos as the explanation for the missing mass of the universe, leaving astrophysicists more baffled for a solution.]
In 'If Theory is Right, Most of Universe is Still “Missing”', New York Times (11 Sep 1984).
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The entire annals of Observation probably do not elsewhere exhibit so extraordinary a verification of any theoretical conjecture adventured on by the human spirit!
[On the mathematical work by Urbain Le Verrier predicting the planet Neptune.]
In The Planet Neptune: An Exposition and History (1848), 90. The verification of the existence of the planet Neptune was made when Johan Galle found a star in an evening observation at the position predicted in the letter he received from Le Verrier earlier that same day.
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The essential fact is that all the pictures which science now draws of nature, and which alone seem capable of according with observational facts, are mathematical pictures.
In The Mysterious Universe (1930), 150.
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The extracellular genesis of cells in animals seemed to me, ever since the publication of the cell theory [of Schwann], just as unlikely as the spontaneous generation of organisms. These doubts produced my observations on the multiplication of blood cells by division in bird and mammalian embryos and on the division of muscle bundles in frog larvae. Since then I have continued these observations in frog larvae, where it is possible to follow the history of tissues back to segmentation.
'Ueber extracellulare Eutstehung thierischer Zelleu und üüber Vermehrung derselben durch Theilung', Archiv für Anatomie, Physiologie und Wissenschaftliche Medicin (1852), 1, 49-50. Quoted in Erwin H. Ackerknecht, Rudolf Virchow: Doctor Statesman Anthropologist (1953), 83-4.
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The faith of scientists in the power and truth of mathematics is so implicit that their work has gradually become less and less observation, and more and more calculation. The promiscuous collection and tabulation of data have given way to a process of assigning possible meanings, merely supposed real entities, to mathematical terms, working out the logical results, and then staging certain crucial experiments to check the hypothesis against the actual empirical results. But the facts which are accepted by virtue of these tests are not actually observed at all. With the advance of mathematical technique in physics, the tangible results of experiment have become less and less spectacular; on the other hand, their significance has grown in inverse proportion. The men in the laboratory have departed so far from the old forms of experimentation—typified by Galileo's weights and Franklin's kite—that they cannot be said to observe the actual objects of their curiosity at all; instead, they are watching index needles, revolving drums, and sensitive plates. No psychology of 'association' of sense-experiences can relate these data to the objects they signify, for in most cases the objects have never been experienced. Observation has become almost entirely indirect; and readings take the place of genuine witness.
Philosophy in a New Key; A Study in Inverse the Symbolism of Reason, Rite, and Art (1942), 19-20.
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The first man who said “fire burns” was employing scientific method, at any rate if he had allowed himself to be burnt several times. This man had already passed through the two stages of observation and generalization. He had not, however, what scientific technique demands—a careful choice of significant facts on the one hand, and, on the other hand, various means of arriving at laws otherwise than my mere generalization. (1931)
In The Scientific Outlook (1931, 2009), 3.
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The first observation of cancer cells in the smear of the uterine cervix gave me one of the greatest thrills I ever experienced during my scientific career.
Quoted on web page http://www.whonamedit.com/doctor.cfm/2402.html
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The foundations of population genetics were laid chiefly by mathematical deduction from basic premises contained in the works of Mendel and Morgan and their followers. Haldane, Wright, and Fisher are the pioneers of population genetics whose main research equipment was paper and ink rather than microscopes, experimental fields, Drosophila bottles, or mouse cages. Theirs is theoretical biology at its best, and it has provided a guiding light for rigorous quantitative experimentation and observation.
'A Review of Some Fundamental Concepts and Problems of Population Genetics', Cold Spring Harbor Symposia on Quantitative Biology, 1955, 20, 13-14.
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The framing of hypotheses is, for the enquirer after truth, not the end, but the beginning of his work. Each of his systems is invented, not that he may admire it and follow it into all its consistent consequences, but that he may make it the occasion of a course of active experiment and observation. And if the results of this process contradict his fundamental assumptions, however ingenious, however symmetrical, however elegant his system may be, he rejects it without hesitation. He allows no natural yearning for the offspring of his own mind to draw him aside from the higher duty of loyalty to his sovereign, Truth, to her he not only gives his affections and his wishes, but strenuous labour and scrupulous minuteness of attention.
Philosophy of the Inductive Sciences (1847), Vol. 2, 57.
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The functional validity of a working hypothesis is not a priori certain, because often it is initially based on intuition. However, logical deductions from such a hypothesis provide expectations (so-called prognoses) as to the circumstances under which certain phenomena will appear in nature. Such a postulate or working hypothesis can then be substantiated by additional observations ... The author calls such expectations and additional observations the prognosis-diagnosis method of research. Prognosis in science may be termed the prediction of the future finding of corroborative evidence of certain features or phenomena (diagnostic facts). This method of scientific research builds up and extends the relations between the subject and the object by means of a circuit of inductions and deductions.
In 'The Scientific Character of Geology', The Journal of Geology (Jul 1961), 69, No. 4, 454-5.
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The history of men of science has one peculiar advantage, as it shows the importance of little things in producing great results. Smeaton learned his principle of constructing a lighthouse, by noticing the trunk of a tree to be diminished from a curve to a cyclinder ... and Newton, turning an old box into a water-clock, or the yard of a house into a sundial, are examples of those habits of patient observation which scientific biography attractively recommends.
Pleasures, Objects, and Advantages of Literature (1855), 129.
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The hypotheses which we accept ought to explain phenomena which we have observed. But they ought to do more than this; our hypotheses ought to foretell phenomena which have not yet been observed; ... because if the rule prevails, it includes all cases; and will determine them all, if we can only calculate its real consequences. Hence it will predict the results of new combinations, as well as explain the appearances which have occurred in old ones. And that it does this with certainty and correctness, is one mode in which the hypothesis is to be verified as right and useful.
Philosophy of the Inductive Sciences (1847), Vol. 2, 62-63.
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The idea of making a fault a subject of study and not an object to be merely determined has been the most important step in the course of my methods of observation. If I have obtained some new results it is to this that I owe it.
'Notice sur les Travaux Scientifiques de Marcel Bertrand' (1894). In Geological Society of London, The Quarterly Journal of the Geological Society of London (May 1908), 64, li.
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The importance of group theory was emphasized very recently when some physicists using group theory predicted the existence of a particle that had never been observed before, and described the properties it should have. Later experiments proved that this particle really exists and has those properties.
Groups in the New Mathematics (1967), 7. Quoted in Rosemary Schmalz, Out of the Mouths of Mathematicians: A Quotation Book for Philomaths (1993), 42.
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The intensity and quantity of polemical literature on scientific problems frequently varies inversely as the number of direct observations on which the discussions are based: the number and variety of theories concerning a subject thus often form a coefficient of our ignorance. Beyond the superficial observations, direct and indirect, made by geologists, not extending below about one two-hundredth of the Earth's radius, we have to trust to the deductions of mathematicians for our ideas regarding the interior of the Earth; and they have provided us successively with every permutation and combination possible of the three physical states of matter—solid, liquid, and gaseous.
'Address delivered by the President of Section [Geology] at Sydney (Friday, Aug 21), Report of the Eighty-Fourth Meeting of the British Association for the Advancement of Science: Australia 1914, 1915, 345.
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The King saw them with no common satisfaction, expressing his desire in no particular to have yt Stellar fish engraven and printed. We wish very much, Sir, yt you could procure for us a particular description of yesd Fish, viz. whether it be common there; what is observable in it when alive; what colour it then hath; what kind of motion in the water; what use it maketh of all that curious workmanship, wch Nature hath adorn'd it with?
to John Winthrop, Jr. (26 Mar 1670), concerning specimens provided by Winthrop to the Society. In A. Rupert Hall & Marie Boas Hall (eds.), The Correspondence of Henry Oldenburg (1969), Vol. 6, 594.
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The knowledge of Natural-History, being Observation of Matters of Fact, is more certain than most others, and in my slender Opinion, less subject to Mistakes than Reasonings, Hypotheses, and Deductions are; ... These are things we are sure of, so far as our Senses are not fallible; and which, in probability, have been ever since the Creation, and will remain to the End of the World, in the same Condition we now find them.
A Voyage to the Islands Madera, Barbados, Nieves, S. Christophers and Jamaica: With the Natural History of the Herbs and Trees, Four-footed Beasts, Fishes, Birds, Insects, Reptiles, &c. of the Last of those Islands (1707), Vol. 1, 1.
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The layman, taught to revere scientists for their absolute respect for the observed facts, and for the judiciously detached and purely provisional manner in which they hold scientific theories (always ready to abandon a theory at the sight of any contradictory evidence) might well have thought that, at [Dayton C.] Miller's announcement of this overwhelming evidence of a “positive effect” [indicating that the speed of light is not independent from the motion of the observer, as Einstein's theory of relativity demands] in his presidential address to the American Physical Society on December 29th, 1925, his audience would have instantly abandoned the theory of relativity. Or, at the very least, that scientists—wont to look down from the pinnacle of their intellectual humility upon the rest of dogmatic mankind—might suspend judgment in this matter until Miller's results could be accounted for without impairing the theory of relativity. But no: by that time they had so well closed their minds to any suggestion which threatened the new rationality achieved by Einstein's world-picture, that it was almost impossible for them to think again in different terms. Little attention was paid to the experiments, the evidence being set aside in the hope that it would one day turn out to be wrong.
Personal Knowledge: Towards a Post-Critical Philosophy (1958, 1998), 13. Miller had earlier presented his evidence against the validity of the relativity theory at the annual meeting, 28 Apr 1925, of the National Academy of Sciences. Miller believed he had, by a much-refined and improved repetition of the so-called Michelson-Morley experiment, shown that there is a definite and measurable motion of the earth through the ether. In 1955, a paper by R.S. Shankland, et al., in Rev. Modern Phys. (1955), 27, 167, concluded that statistical fluctuations and temperature effects in the data had simulated what Miller had taken to be he apparent ether drift.
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The leading idea which is present in all our [geological] researches, and which accompanies every fresh observation, the sound of which to the ear of the student of Nature seems echoed from every part of her works, is—Time!—Time!—Time!
The Geology and Extinct Volcanoes of Central France (2nd ed., 1858), 208-9.
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The magnet's name the observing Grecians drew
From the magnetic region where it grew.
Lucretius, as quoted by William Gilbert in De Magnete. Cited in Gerrit L. Verschuur, Hidden Attraction (1996), 3.
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The more important fundamental laws and facts of physical science have all been discovered, and these are now so firmly established that the possibility of their ever being supplanted in consequence of new discoveries is exceedingly remote. Nevertheless, it has been found that there are apparent exceptions to most of these laws, and this is particularly true when the observations are pushed to a limit, i.e., whenever the circumstances of experiment are such that extreme cases can be examined. Such examination almost surely leads, not to the overthrow of the law, but to the discovery of other facts and laws whose action produces the apparent exceptions. As instances of such discoveries, which are in most cases due to the increasing order of accuracy made possible by improvements in measuring instruments, may be mentioned: first, the departure of actual gases from the simple laws of the so-called perfect gas, one of the practical results being the liquefaction of air and all known gases; second, the discovery of the velocity of light by astronomical means, depending on the accuracy of telescopes and of astronomical clocks; third, the determination of distances of stars and the orbits of double stars, which depend on measurements of the order of accuracy of one-tenth of a second-an angle which may be represented as that which a pin's head subtends at a distance of a mile. But perhaps the most striking of such instances are the discovery of a new planet or observations of the small irregularities noticed by Leverrier in the motions of the planet Uranus, and the more recent brilliant discovery by Lord Rayleigh of a new element in the atmosphere through the minute but unexplained anomalies found in weighing a given volume of nitrogen. Many other instances might be cited, but these will suffice to justify the statement that “our future discoveries must be looked for in the sixth place of decimals.”
Light Waves and Their Uses (1903), 23-4.
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The observer is not he who merely sees the thing which is before his eyes, but he who sees what parts the thing is composed of. To do this well is a rare talent. One person, from inattention, or attending only in the wrong place, overlooks half of what he sees; another sets down much more than he sees, confounding it with what he imagines, or with what he infers; another takes note of the kind of all the circumstances, but being inexpert in estimating their degree, leaves the quantity of each vague and uncertain; another sees indeed the whole, but makes such an awkward division of it into parts, throwing into one mass things which require to be separated, and separating others which might more conveniently be considered as one, that the result is much the same, sometimes even worse than if no analysis had been attempted at all.
In A System of Logic Ratiocinative and Inductive (1858), 216.
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The observer listens to nature: the experimenter questions and forces her to reveal herself.
Attributed.
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The opinion I formed from attentive observation of the facts and phenomena, is as follows. When ice, for example, or any other solid substance, is changing into a fluid by heat, I am of opinion that it receives a much greater quantity of heat than that what is perceptible in it immediately after by the thermometer. A great quantity of heat enters into it, on this occasion, without making it apparently warmer, when tried by that instrument. This heat, however, must be thrown into it, in order to give it the form of a fluid; and I affirm, that this great addition of heat is the principal, and most immediate cause of the fluidity induced. And, on the other hand, when we deprive such a body of its fluidity again, by a diminution of its heat, a very great quantity of heat comes out of it, while it is assuming a solid form, the loss of which heat is not to be perceived by the common manner of using the thermometer. The apparent heat of the body, as measured by that instrument, is not diminished, or not in proportion to the loss of heat which the body actually gives out on this occasion; and it appears from a number of facts, that the state of solidity cannot be induced without the abstraction of this great quantity of heat. And this confirms the opinion, that this quantity of heat, absorbed, and, as it were, concealed in the composition of fluids, is the most necessary and immediate cause of their fluidity.
Lectures on the Elements of Chemistry, delivered in the University of Edinburgh (1803), Vol. I, 116-7.
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The person who observes a clock, sees in it not only the pendulum swinging to and fro, and the dial-plate, and the hands moving, for a child can see all this; but he sees also the parts of the clock, and in what connexion the suspended weight stands to the wheel-work, and the pendulum to the moving hands.
'The Study of the Natural Sciences: An Introductory Lecture to the Course of Experimental Chemistry in the University of Munich, for the Winter Session of 1852-53,' as translated and republished in The Medical Times and Gazette (22 Jan 1853), N.S. Vol. 6, 82.
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The phenomena of nature, especially those that fall under the inspection of the astronomer, are to be viewed, not only with the usual attention to facts as they occur, but with the eye of reason and experience.
'An Account of Three Volcanoes on the Moon', read before the Royal Society, Philosophical Transactions (1787). Reprinted in Edward Polehampton, The Gallery of Nature and Art; or, a Tour Through Creation and Science (1815), 183.
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The physicist is like someone who’s watching people playing chess and, after watching a few games, he may have worked out what the moves in the game are. But understanding the rules is just a trivial preliminary on the long route from being a novice to being a grand master. So even if we understand all the laws of physics, then exploring their consequences in the everyday world where complex structures can exist is a far more daunting task, and that’s an inexhaustible one I'm sure.
In Lewis Wolpert and Alison Richards, A Passion For Science (1988), 37.
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The present state of the system of nature is evidently a consequence of what it was in the preceding moment, and if we conceive of an intelligence that at a given instant comprehends all the relations of the entities of this universe, it could state the respective position, motions, and general affects of all these entities at any time in the past or future. Physical astronomy, the branch of knowledge that does the greatest honor to the human mind, gives us an idea, albeit imperfect, of what such an intelligence would be. The simplicity of the law by which the celestial bodies move, and the relations of their masses and distances, permit analysis to follow their motions up to a certain point; and in order to determine the state of the system of these great bodies in past or future centuries, it suffices for the mathematician that their position and their velocity be given by observation for any moment in time. Man owes that advantage to the power of the instrument he employs, and to the small number of relations that it embraces in its calculations. But ignorance of the different causes involved in the production of events, as well as their complexity, taken together with the imperfection of analysis, prevents our reaching the same certainty about the vast majority of phenomena. Thus there are things that are uncertain for us, things more or less probable, and we seek to compensate for the impossibility of knowing them by determining their different degrees of likelihood. So it was that we owe to the weakness of the human mind one of the most delicate and ingenious of mathematical theories, the science of chance or probability.
'Recherches, 1º, sur l'Intégration des Équations Différentielles aux Différences Finies, et sur leur Usage dans la Théorie des Hasards' (1773, published 1776). In Oeuvres complètes de Laplace, 14 Vols. (1843-1912), Vol. 8, 144-5, trans. Charles Coulston Gillispie, Pierre-Simon Laplace 1749-1827: A Life in Exact Science (1997), 26.
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The process of discovery is very simple. An unwearied and systematic application of known laws to nature, causes the unknown to reveal themselves. Almost any mode of observation will be successful at last, for what is most wanted is method.
A Week on the Concord and Merrimack Rivers (1873), 384.
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The process of tracing regularity in any complicated, and at first sight confused, set of appearances, is necessarily tentative; we begin by making any supposition, even a false one, to see what consequences will follow from it ; and by observing how these differ from the real phenomena, we learn what corrections to make in our assumption.
A System of Logic, Ratiocinative and Inductive (1858), 295.
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The sciences do not try to explain, they hardly even try to interpret, they mainly make models. By a model is meant a mathematical construct which, with the addition of certain verbal interpretations, describes observed phenomena. The justification of such a mathematical construct is solely and precisely that it is expected to work—that is, correctly to describe phenomena from a reasonably wide area.
'Method in the Physical Sciences', in The Unity of Knowledge, editted by L. Leary (1955), 158. Reprinted in John Von Neumann, F. Bródy (ed.) and Tibor Vámos (ed.), The Neumann Compendium (2000), 628.
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The significance of a fact is relative to [the general body of scientific] knowledge. To say that a fact is significant in science, is to say that it helps to establish or refute some general law; for science, though it starts from observation of the particular, is not concerned essentially with the particular, but with the general. A fact, in science, is not a mere fact, but an instance. In this the scientist differs from the artist, who, if he deigns to notice facts at all, is likely to notice them in all their particularity.
In The Scientific Outlook (1931, 2009), 38.
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The situation with regard to insulin is particularly clear. In many parts of the world diabetic children still die from lack of this hormone. ... [T]hose of us who search for new biological facts and for new and better therapeutic weapons should appreciate that one of the central problems of the world is the more equitable distribution and use of the medical and nutritional advances which have already been established. The observations which I have recently made in parts of Africa and South America have brought this fact very forcible to my attention.
'Studies on Diabetes and Cirrhosis', Proceedings, American Philosophical Society (1952) 96, No. 1, 29.
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The star [Tycho's supernova] was at first like Venus and Jupiter, giving pleasing effects; but as it then became like Mars, there will next come a period of wars, seditions, captivity and death of princes, and destruction of cities, together with dryness and fiery meteors in the air, pestilence, and venomous snakes. Lastly, the star became like Saturn, and there will finally come a time of want, death, imprisonment and all sorts of sad things.
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The Sun is no lonelier than its neighbors; indeed, it is a very common-place star,—dwarfish, though not minute,—like hundreds, nay thousands, of others. By accident the brighter component of Alpha Centauri (which is double) is almost the Sun's twin in brightness, mass, and size. Could this Earth be transported to its vicinity by some supernatural power, and set revolving about it, at a little less than a hundred million miles' distance, the star would heat and light the world just as the Sun does, and life and civilization might go on with no radical change. The Milky Way would girdle the heavens as before; some of our familiar constellations, such as Orion, would be little changed, though others would be greatly altered by the shifting of the nearer stars. An unfamiliar brilliant star, between Cassiopeia and Perseus would be—the Sun. Looking back at it with our telescopes, we could photograph its spectrum, observe its motion among the stars, and convince ourselves that it was the same old Sun; but what had happened to the rest of our planetary system we would not know.
The Solar System and its Origin (1935), 2-3.
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The true method of discovery is like the flight of an aeroplane. It starts from the ground of particular observation; it makes a flight in the thin air of imaginative generalization; and it again lands for renewed observation rendered acute by rational interpretation.
Gifford lectures delivered in the University of Edinburgh during the session 1927-28. Process and Reality: An Essay in Cosmology (1929, 1979), 5.
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The truth is, the Science of Nature has been already too long made only a work of the Brain and the Fancy: It is now high time that it should return to the plainness and soundness of Observations on material and obvious things.
Micrographia (1665). In Extracts from Micrographia (1906), 10.
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The two fulcra of medicine are reason and observation. Observation is the clue to guide the physician in his thinking.
Praxi Medica (1696), Introduction.
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The universe does not exist 'out there,' independent of us. We are inescapably involved in bringing about that which appears to be happening. We are not only observers. We are participators. In some strange sense, this is a participatory universe. Physics is no longer satisfied with insights only into particles, fields of force, into geometry, or even into time and space. Today we demand of physics some understanding of existence itself.
Quoted in Denis Brian, The Voice Of Genius: Conversations with Nobel Scientists and Other Luminaries, 127.
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The value the world sets upon motives is often grossly unjust and inaccurate. Consider, for example, two of them: mere insatiable curiosity and the desire to do good. The latter is put high above the former, and yet it is the former that moves some of the greatest men the human race has yet produced: the scientific investigators. What animates a great pathologist? Is it the desire to cure disease, to save life? Surely not, save perhaps as an afterthought. He is too intelligent, deep down in his soul, to see anything praiseworthy in such a desire. He knows by life-long observation that his discoveries will do quite as much harm as good, that a thousand scoundrels will profit to every honest man, that the folks who most deserve to be saved will probably be the last to be saved. No man of self-respect could devote himself to pathology on such terms. What actually moves him is his unquenchable curiosity–his boundless, almost pathological thirst to penetrate the unknown, to uncover the secret, to find out what has not been found out before. His prototype is not the liberator releasing slaves, the good Samaritan lifting up the fallen, but the dog sniffing tremendously at an infinite series of rat-holes.
Prejudices (1923), 269-70.
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The Vermin only teaze and pinch
Their foes superior by an Inch.
So, Naturalists observe, a Flea
Hath smaller Fleas that on him prey,
And these have smaller Fleas to bite 'em.
And so proceed ad infinitum.
On Poetry: A Rhapsody (1735), lines 339-44.
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The word 'chance' then expresses only our ignorance of the causes of the phenomena that we observe to occur and to succeed one another in no apparent order. Probability is relative in part to this ignorance, and in part to our knowledge.
'Mémoire sur les Approximations des Formules qui sont Fonctions de Très Grands Nombres' (1783, published 1786). In Oeuvres complète de Laplace, 14 Vols. (1843-1912), Vol. 10, 296, trans. Charles Coulston Gillispie, Pierre-Simon Laplace 1749-1827: A Life in Exact Science (1997), 91.
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Their specific effect on the glucosides might thus be explained by assuming that the intimate contact between the molecules necessary for the release of the chemical reaction is possible only with similar geometrical configurations. To give an illustration I will say that enzyme and glucoside must fit together like lock and key in order to be able to exercise a chemical action on each other. This concept has undoubtedly gained in probability and value for stereochemical research, after the phenomenon itself was transferred from the biological to the purely chemical field. It is an extension of the theory of asymmetry without being a direct consequence of it: for the conviction that the geometrical structure of the molecule even for optical isomers exercises such a great influence on the chemical affinities, in my opinion could only be gained by new actual observations.
'Einfluss der Configuration auf die wirkung der Enzyme', Berichte der deutschen Chemischen Gesellschaft, 1894, 27, 2985-93. Trans. B. Holmstedt and G. Liljestrand (eds.) Readings in Pharmacology (1963), 251.
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Theories should not be used to select observations; on the contrary, it is observations which should be used to select the theories.
Anonymous
From webpage 'The Selection Effect' on laserstars.org website. The article does not specify an author, but the homepage attributes the site to Y.P. Varshni and J. Talbot.
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Theory and fact are equally strong and utterly interdependent; one has no meaning without the other. We need theory to organize and interpret facts, even to know what we can or might observe. And we need facts to validate theories and give them substance.
Leonardo's Mountain of Clams and the Diet of Worms: Essays on Natural History (1998), 155.
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There are certain general Laws that run through the whole Chain of natural Effects: these are learned by the Observation and Study of Nature, and are by Men applied as well to the framing artificial things for the Use and Ornament of Life, as to the explaining the various Phænomena: Which Explication consists only in shewing the Conformity any particular Phænomenon hath to the general Laws of Nature, or, which is the same thing, in discovering the Uniformity there is in the production of natural Effects; as will be evident to whoever shall attend to the several Instances, wherin Philosophers pretend to account for Appearances.
A Treatise Concerning the Principles of Human Knowledge [first published 1710], (1734), 87-8.
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There is no art so difficult as the art of observation: it requires a skillful, sober spirit and a well-trained experience, which can only be acquired by practice; for he is not an observer who only sees the thing before him with his eyes, but he who sees of what parts the thing consists, and in what connexion the parts stand to the whole. One person overlooks half from inattention; another relates more than he sees while he confounds it with that which he figures to himself; another sees the parts of the whole, but he throws things together that ought to be separated. ... When the observer has ascertained the foundation of a phenomenon, and he is able to associate its conditions, he then proves while he endeavours to produce the phenomena at his will, the correctness of his observations by experiment. To make a series of experiments is often to decompose an opinion into its individual parts, and to prove it by a sensible phenomenon. The naturalist makes experiments in order to exhibit a phenomenon in all its different parts. When he is able to show of a series of phenomena, that they are all operations of the same cause, he arrives at a simple expression of their significance, which, in this case, is called a Law of Nature. We speak of a simple property as a Law of Nature when it serves for the explanation of one or more natural phenomena.
'The Study of the Natural Sciences: An Introductory Lecture to the Course of Experimental Chemistry in the University of Munich, for the Winter Session of 1852-53,' as translated and republished in The Medical Times and Gazette (22 Jan 1853), N.S. Vol. 6, 82.
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These motions were such as to satisfy me, after frequently repeated observation, that they arose neither from currents in the fluid, nor from its gradual evaporation, but belonged to the particle itself.
Summary of Brownian motion.
A Brief Account of Microscopical Observations made in the Middle of June, July, and August, 1827, on the Particles Contained in the Pollen of Plants', Philosophical Magazine, 1828, NS 4, 162-3.
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These two orders of mountains [Secondary and Tertiary] offer the most ancient chronicle of our globe, least liable to falsifications and at the same time more legible than the writing of the primitive ranges. They are Nature's archives, prior to even the most remote records and traditions that have been preserved for our observant century to investigate, comment on and bring to the light of day, and which will not be exhausted for several centuries after our own.
Observations sur la Formation des Montagnes', Acta Academiae Scientiarum Imperialis Petropolitanae (1777) [1778], 46. Trans. Albert Carozzi.
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Things of which there is sight, hearing, apprehension, these I prefer.
Heraclitus, fr. 55. Trans. R. W. Sharples.

This success permits us to hope that after thirty or forty years of observation on the new Planet [Neptune], we may employ it, in its turn, for the discovery of the one following it in its order of distances from the Sun. Thus, at least, we should unhappily soon fall among bodies invisible by reason of their immense distance, but whose orbits might yet be traced in a succession of ages, with the greatest exactness, by the theory of Secular Inequalities.
[Following the success of the confirmation of the existence of the planet Neptune, he considered the possibility of the discovery of a yet further planet.]
In John Pringle Nichol, The Planet Neptune: An Exposition and History (1848), 90.
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Thus one becomes entangled in contradictions if one speaks of the probable position of the electron without considering the experiment used to determine it ... It must also be emphasized that the statistical character of the relation depends on the fact that the influence of the measuring device is treated in a different manner than the interaction of the various parts of the system on one another. This last interaction also causes changes in the direction of the vector representing the system in the Hilbert space, but these are completely determined. If one were to treat the measuring device as a part of the system—which would necessitate an extension of the Hilbert space—then the changes considered above as indeterminate would appear determinate. But no use could be made of this determinateness unless our observation of the measuring device were free of indeterminateness. For these observations, however, the same considerations are valid as those given above, and we should be forced, for example, to include our own eyes as part of the system, and so on. The chain of cause and effect could be quantitatively verified only if the whole universe were considered as a single system—but then physics has vanished, and only a mathematical scheme remains. The partition of the world into observing and observed system prevents a sharp formulation of the law of cause and effect. (The observing system need not always be a human being; it may also be an inanimate apparatus, such as a photographic plate.)
The Physical Principles of the Quantum Theory, trans. Carl Eckart and Frank C. Hoyt (1949), 58.
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Thus the system of the world only oscillates around a mean state from which it never departs except by a very small quantity. By virtue of its constitution and the law of gravity, it enjoys a stability that can be destroyed only by foreign causes, and we are certain that their action is undetectable from the time of the most ancient observations until our own day. This stability in the system of the world, which assures its duration, is one of the most notable among all phenomena, in that it exhibits in the heavens the same intention to maintain order in the universe that nature has so admirably observed on earth for the sake of preserving individuals and perpetuating species.
'Sur l'Équation Séculaire de la Lune' (1786, published 1788). In Oeuvres complètes de Laplace, 14 Vols. (1843-1912), Vol. 11, 248-9, trans. Charles Coulston Gillispie, Pierre-Simon Laplace 1749-1827: A Life in Exact Science (1997), 145.
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To consider the matter aright, reason is nothing but a wonderful and unintelligible instinct in our souls, which carries us along a certain train of ideas, and endows them with particular qualities, according to their particular situations and relations. This instinct, 'tis true, arises from past observation and experience; but can anyone give the ultimate reason, why past experience and observation produces such an effect, any more than why nature alone should produce it?
A Treatise on Human Nature (1739-40), ed. L. A. Selby-Bigge (1888), book 1, part 3, section 16, 179.
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To discover a Conception of the mind which will justly represent a train of observed facts is, in some measure, a process of conjecture, ... and the business of conjecture is commonly conducted by calling up before our minds several suppositions, selecting that one which most agrees with what we know of the observed facts. Hence he who has to discover the laws of nature may have to invent many suppositions before he hits upon the right one; and among the endowments which lead to his success, we must reckon that fertility of invention which ministers to him such imaginary schemes, till at last he finds the one which conforms to the true order of nature.
Philosophy of the Inductive Sciences (1847), Vol. 2, 54.
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To find out what happens to a system when you interfere with it you have to interfere with it (not just passively observe it).
Use and Abuse of Regression (1966), 629.
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To Observations which ourselves we make,
We grow more partial for th' observer's sake.
'Moral Essays', Epistle I, to Richard Temple, Viscount Cobham (1734). In John Butt (ed.), The Poems of Alexander Pope (1965), 550.
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To study men, we must look close by; to study man, we must learn to look afar; if we are to discover essential characteristics, we must first observe differences.
Essai sur l'origine des langues (1781), 384
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Today we no longer ask what really goes on in an atom; we ask what is likely to be observed—and with what likelihood—when we subject atoms to any specified influences such as light or heat, magnetic fields or electric currents.
What Little I Remember (1979), 20.
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We have not known a single great scientist who could not discourse freely and interestingly with a child. Can it be that haters of clarity have nothing to say, have observed nothing, have no clear picture of even their own fields?
In John Steinbeck and Edward Flanders Ricketts, Sea of Cortez: a Leisurely Journal of Travel and Research (1941), 73.
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We have seven or eight geological facts, related by Moses on the one part, and on the other, deduced solely from the most exact and best verified geological observations, and yet agreeing perfectly with each other, not only in substance, but in the order of their succession... That two accounts derived from sources totally distinct from and independent on each other should agree not only in the substance but in the order of succession of two events only, is already highly improbable, if these facts be not true, both substantially and as to the order of their succession. Let this improbability, as to the substance of the facts, be represented only by 1/10. Then the improbability of their agreement as to seven events is 1.7/10.7 that is, as one to ten million, and would be much higher if the order also had entered into the computation.
Geological Essays (1799), 52-3.
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We have three approaches at our disposal: the observation of nature, reflection, and experimentation. Observation serves to assemble the data, reflection to synthesise them and experimentation to test the results of the synthesis. The observation of nature must be assiduous, just as reflection must be profound, and experimentation accurate. These three approaches are rarely found together, which explains why creative geniuses are so rare.
Thoughts on the Interpretation of Nature and Other Philosophical Works (1753/4), ed. D. Adams (1999), section XV, 42.
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We must trust to nothing but facts: These are presented to us by Nature, and cannot deceive. We ought, in every instance, to submit our reasoning to the test of experiment, and never to search for truth but by the natural road of experiment and observation.
Elements of Chemistry (1790), trans. R. Kerr, Preface, xviii.
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We need another and a wiser and perhaps a more mystical concept of animals. Remote from universal nature, and living by complicated artifice, man in civilization surveys the creature through the glass of his knowledge and sees thereby a feather magnified and the whole image in distortion. We patronize them for their incompleteness, for their tragic fate of having taken form so far below ourselves. And therein we err, and greatly err. For the animal shall not be measured by man. In a world older and more complete than ours they move finished and complete, gifted with extensions of the senses we have lost or never attained, living by voices we shall never hear. They are not brethren, they are not underlings; they are other nations, caught with ourselves in the net of life and time, fellow prisoners of the splendour and travail of the earth.
The Outermost House (1928), 25.
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We ought to observe that practice which is the hardest of all—especially for young physicians—we ought to throw in no medicine at all—to abstain—to observe a wise and masterly inactivity.
Speech (25 Jan 1828), in Register of Debates in Congress, Vol. 4, Col. 1170.
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We receive experience from nature in a series of messages. From these messages we extract a content of information: that is, we decode the messages in some way. And from this code of information we then make a basic vocabulary of concepts and a basic grammar of laws, which jointly describe the inner organization that nature translates into the happenings and the appearances we meet.
The Identity of Man. Quoted in Richard Dawkins, The Oxford Book of Modern Science Writing (2008), 176-7.
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Well-established theories collapse under the weight of new facts and observations which cannot be explained, and then accumulate to the point where the once useful theory is clearly obsolete.
[Using Thomas S. Kuhn's theories to frame his argument about the relationship beween science and technology: as new facts continue to accumulate, a new, more accurate paradigm must replace the old one.]
Al Gore
Commencement address at M.I.T. (7 Jun 1996). In obituary, 'Thomas S. Kuhn', The Tech (26 Jun 1996), 9.
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Were I disposed to consider the comparative merit of each of them [facts or theories in medical practice], I should derive most of the evils of medicine from supposed facts, and ascribe all the remedies which have been uniformly and extensively useful, to such theories as are true. Facts are combined and rendered useful only by means of theories, and the more disposed men are to reason, the more minute and extensive they become in their observations
Quoted in John Edmonds Stock, Memoirs of the life of Thomas Beddoes (1810), 401.
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What animates a great pathologist? Is it the desire to cure disease, to save life? Surely not, save perhaps as an afterthought. He is too intelligent, deep in his soul, to see anything praiseworthy in such a desire. He knows from life-long observation that his discoveries will do quite as much harm as good, that a thousand scoundrels will profit to every honest man, that the folks who most deserve to be saved will probably be the last to be saved. ... What actually moves him is his unquenchable curiosity—his boundless, almost pathological thirst to penetrate the unknown, to uncover the secret, to find out what has not been found out before. ... [like] the dog sniffing tremendously at an infinite series of rat-holes. ... And yet he stands in the very front rank of the race
In 'The Scientist', Prejudices: third series (1922), 269-70.
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What caused me to undertake the catalog was the nebula I discovered above the southern horn of Taurus on September 12, 1758, while observing the comet of that year. ... This nebula had such a resemblance to a comet in its form and brightness that I endeavored to find others, so that astronomers would not confuse these same nebulae with comets just beginning to shine. I observed further with suitable refractors for the discovery of comets, and this is the purpose I had in mind in compiling the catalog.
After me, the celebrated Herschel published a catalog of 2000 which he has observed. This unveiling the sky, made with instruments of great aperture, does not help in the perusal of the sky for faint comets. Thus my object is different from his, and I need only nebulae visible in a telescope of two feet [focal length].
Connaissance des Temps for 1800/1801. In Charles Coulston Gillespie (ed.), Dictionary of Scientific Biography (1974), Vol. 9, 330.
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What really matters for me is … the more active role of the observer in quantum physics … According to quantum physics the observer has indeed a new relation to the physical events around him in comparison with the classical observer, who is merely a spectator.
Letter to Niels Bohr (1955). Quoted in Robert J. Scully, The Demon and the Quantum (2007), 22.
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What the use of P [the significance level] implies, therefore, is that a hypothesis that may be true may be rejected because it has not predicted observable results that have not occurred.
Theory of Probability (1939), 316.
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What we do see depends mainly on what we look for. ... In the same field the farmer will notice the crop, the geologists the fossils, botanists the flowers, artists the colouring, sportmen the cover for the game. Though we may all look at the same things, it does not all follow that we should see them.
The Beauties of Nature (1893, 2009), 12.

What we observe is not nature itself but nature exposed to our method of questioning. Our scientific work in physics consists in asking questions about nature in the language that we possess and trying to get an answer from experiment by the means that are at our disposal.
Physics and Philosophy: The Revolution in Modern Science (1958), 78.
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When an observation is made on any atomic system that has been prepared in a given way and is thus in a given state, the result will not in general be determinate, i.e. if the experiment is repeated several times under identical conditions several different results may be obtained. If the experiment is repeated a large number of times it will be found that each particular result will be obtained a definite fraction of the total number of times, so that one can say there is a definite probability of its being obtained any time that the experiment is performed. This probability the theory enables one to calculate. (1930)
The Principles of Quantum Mechanics 4th ed. (1981), 13-14
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When Galileo caused balls, the weights of which he had himself previously determined, to roll down an inclined plane; when Torricelli made the air carry a weight which he had calculated beforehand to be equal to that of a definite volume of water; or in more recent times, when Stahl changed metal into lime, and lime back into metal, by withdrawing something and then restoring it, a light broke upon all students of nature. They learned that reason has insight only into that which it produces after a plan of its own, and that it must not allow itself to be kept, as it were, in nature's leading-strings, but must itself show the way with principles of judgement based upon fixed laws, constraining nature to give answer to questions of reason's own determining. Accidental observations, made in obedience to no previously thought-out plan, can never be made to yield a necessary law, which alone reason is concerned to discover.
Critique of Pure Reason (1781), trans. Norman Kemp Smith (1929), 20.
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Where the untrained eye will see nothing but mire and dirt, Science will often reveal exquisite possibilities. The mud we tread under our feet in the street is a grimy mixture of clay and sand, soot and water. Separate the sand, however, as Ruskinn observes—let the atoms arrange themselves in peace according to their nature—and you have the opal. Separate the clay, and it becomes a white earth, fit for the finest porcelain; or if it still further purifies itself, you have a sapphire. Take the soot, and it properly treated it will give you a diamond. While lastly, the water, purified and distilled, will become a dew-drop, or crystallize into a lovely star. Or, again, you may see as you will in any shallow pool either the mud lying at the bottom, or the image of the heavens above.
The Pleasures of Life (1887, 2007), 63.
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Whether we like it or not, quantification in history is here to stay for reasons which the quantifiers themselves might not actively approve. We are becoming a numerate society: almost instinctively there seems now to be a greater degree of truth in evidence expressed numerically than in any literary evidence, no matter how shaky the statistical evidence, or acute the observing eye.
Is History Sick? (1973), 64.
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While reading in a textbook of chemistry, ... I came across the statement, 'nitric acid acts upon copper.' I was getting tired of reading such absurd stuff and I determined to see what this meant. Copper was more or less familiar to me, for copper cents were then in use. I had seen a bottle marked 'nitric acid' on a table in the doctor's office where I was then 'doing time.' I did not know its peculiarities, but I was getting on and likely to learn. The spirit of adventure was upon me. Having nitric acid and copper, I had only to learn what the words 'act upon' meant... I put one of them [cent] on the table, opened the bottle marked 'nitric acid'; poured some of the liquid on the copper; and prepared to make an observation. But what was this wonderful thing which I beheld? The cent was already changed, and it was no small change either. A greenish blue liquid foamed and fumed over the cent and over the table. The air in the neighborhood of the performance became colored dark red. A great colored cloud arose. This was disagreeable and suffocating—how should I stop this? I tried to get rid of the objectionable mess by picking it up and throwing it out of the window, which I had meanwhile opened. I learned another fact—nitric acid not only acts upon copper but it acts upon fingers. The pain led to another unpremeditated experiment. I drew my fingers across my trousers and another fact was discovered. Nitric acid acts upon trousers. Taking everything into consideration, that was the most impressive experiment, and, relatively, probably the most costly experiment I have ever performed.
F. H. Getman, The Life of Ira Remsen (1940), 9.
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Whoever wishes to acquire a deep acquaintance with Nature must observe that there are analogies which connect whole branches of science in a parallel manner, and enable us to infer of one class of phenomena what we know of another. It has thus happened on several occasions that the discovery of an unsuspected analogy between two branches of knowledge has been the starting point for a rapid course of discovery.
Principles of Science: A Treatise on Logic and Scientific Method (1874, 2nd ed., 1913), 631.
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With increasing distance, our knowledge fades, and fades rapidly. Eventually, we reach the dim boundary—the utmost limits of our telescopes. There, we measure shadows, and we search among ghostly errors of measurement for landmarks that are scarcely more substantial. The search will continue. Not until the empirical resources are exhausted, need we pass on to the dreamy realms of speculation.
The Realm of the Nebulae (1936), 202.
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Yet in this my stars were not Mercury as morning star in the angle of the seventh house, in quartile with Mars, but they were Copernicus, they were Tycho Brahe, without whose books of observations everything which has now been brought by me into the brightest daylight would lie buried in darkness.
Harmonice Mundi, The Harmony of the World (1619), book IV, Epilogue on Sublunary Nature. Trans. E. J. Aiton, A. M. Duncan and J. V. Field (1997), 377.
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You are urgently warned against allowing yourself to be influenced in any way by theories or by other preconceived notions in the observation of phenomena, the performance of analyses and other determinations.
Laboratory Rules at Munich. Quoted by M. Bergmann, 'Fischer', in Bugge's Das Buch der Grosse Chemiker. Trans. Joseph S. Froton, Contrasts in Scientific Style: Research Groups in the Chemical and Biomedical Sciences (1990), 172.
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You can observe a lot by watching.
Remark to a reporter after the 1963 baseball season. In When You Come to a Fork in the Road, Take It! (2002), 66.

[All phenomena] are equally susceptible of being calculated, and all that is necessary, to reduce the whole of nature to laws similar to those which Newton discovered with the aid of the calculus, is to have a sufficient number of observations and a mathematics that is complex enough.
Unpublished Manuscript. Quoted In Frank E. Manuel, The Prophets of Paris (1962), 73.
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[An engineer's] invention causes things to come into existence from ideas, makes world conform to thought; whereas science, by deriving ideas from observation, makes thought conform to existence.
Types of Technology', Research in Philosophy & Technology (1978), Vol. 1, 244.
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[Henry Cavendish] fixed the weight of the earth; he established the proportions of the constituents of the air; he occupied himself with the quantitative study of the laws of heat; and lastly, he demonstrated the nature of water and determined its volumetric composition. Earth, air, fire, and water—each and all came within the range of his observations.
Essays in Historical Chemistry (1894), 86.
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[It] may be laid down as a general rule that, if the result of a long series of precise observations approximates a simple relation so closely that the remaining difference is undetectable by observation and may be attributed to the errors to which they are liable, then this relation is probably that of nature.
'Mémoire sur les Inégalites Séculaires des Planètes et des Satellites' (I 785, published 1787). In Oeuvres completes de Laplace, 14 Vols. (1843-1912), Vol. 11, 57, trans. Charles Coulston Gillispie, Pierre-Simon Laplace 1749-1827: A Life in Exact Science (1997), 130.
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[Louis Rendu, Bishop of Annecy] collects observations, makes experiments, and tries to obtain numerical results; always taking care, however, so to state his premises and qualify his conclusions that nobody shall be led to ascribe to his numbers a greater accuracy than they merit. It is impossible to read his work, and not feel that he was a man of essentially truthful mind and that science missed an ornament when he was appropriated by the Church.
In The Glaciers of the Alps (1860), 299.
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[Modern science] passed through a long period of uncertainty and inconclusive experiment, but as the instrumental aids to research improved, and the results of observation accumulated, phantoms of the imagination were exorcised, idols of the cave were shattered, trustworthy materials were obtained for logical treatment, and hypotheses by long and careful trial were converted into theories.
In The Present Relations of Science and Religion (1913, 2004), 3
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[My] numberless observations... made on the Strata... [have] made me confident of their uniformity throughout this Country & [have] led me to conclude that the same regularity... will be found to extend to every part of the Globe for Nature has done nothing by piecemeal. [T]here is no inconsistency in her productions. [T]he Horse never becomes an Ass nor the Crab an Apple by any intermixture or artificial combination whatever[. N]or will the Oak ever degenerate into an Ash or an Ash into an Elm. [H]owever varied by Soil or Climate the species will still be distinct on this ground. [T]hen I argue that what is found here may be found elsewhere[.] When proper allowances are made for such irregularities as often occur and the proper situation and natural agreement is well understood I am satisfied there will be no more difficulty in ascertaining the true quality of the Strata and the place of its possition [sic] than there is now in finding the true Class and Character of Plants by the Linean [sic] System.
Natural Order of the Strata in England and Wales Accurately Delineated and Described, unpublished manuscript, Department of Geology, University of Oxford, 1801, f. 7v.
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[The internet] ought to be like clay, rather than a sculpture that you observe from a distance.
From archive interview (Nov 1999) rebroadcast on PBS radio program Science Friday (14 Mar 2014).
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[The] weakness of biological balance studies has aptly been illustrated by comparison with the working of a slot machine. A penny brings forth one package of chewing gum; two pennies bring forth two. Interpreted according to the reasoning of balance physiology, the first observation is an indication of the conversion of copper into gum; the second constitutes proof.
[Co-author with David Rittenberg (1906-70).]
'The Application of Isotopes to the Study of Intermediary Metabolism', Science (1938), 87, 222.
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…separation of the observer from the phenomenon to be observed is no longer possible.
Quoted in Robert J. Scully, The Demon and the Quantum (2007), 3.
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“I see nobody on the road,” said Alice.
“I only wish I had such eyes,” the King remarked in a fretful tone. “To be able to see Nobody! And at that distance too! Why, it's as much as I can do to see real people, by this light.”
Through the Looking Glass and What Alice Found There (1871, 1950), 53.
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Carl Sagan Thumbnail In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion. (1987) -- Carl Sagan
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- 100 -
Sophie Germain
Gertrude Elion
Ernest Rutherford
James Chadwick
Marcel Proust
William Harvey
Johann Goethe
John Keynes
Carl Gauss
Paul Feyerabend
- 90 -
Antoine Lavoisier
Lise Meitner
Charles Babbage
Ibn Khaldun
Euclid
Ralph Emerson
Robert Bunsen
Frederick Banting
Andre Ampere
Winston Churchill
- 80 -
John Locke
Bronislaw Malinowski
Bible
Thomas Huxley
Alessandro Volta
Erwin Schrodinger
Wilhelm Roentgen
Louis Pasteur
Bertrand Russell
Jean Lamarck
- 70 -
Samuel Morse
John Wheeler
Nicolaus Copernicus
Robert Fulton
Pierre Laplace
Humphry Davy
Thomas Edison
Lord Kelvin
Theodore Roosevelt
Carolus Linnaeus
- 60 -
Francis Galton
Linus Pauling
Immanuel Kant
Martin Fischer
Robert Boyle
Karl Popper
Paul Dirac
Avicenna
James Watson
William Shakespeare
- 50 -
Stephen Hawking
Niels Bohr
Nikola Tesla
Rachel Carson
Max Planck
Henry Adams
Richard Dawkins
Werner Heisenberg
Alfred Wegener
John Dalton
- 40 -
Pierre Fermat
Edward Wilson
Johannes Kepler
Gustave Eiffel
Giordano Bruno
JJ Thomson
Thomas Kuhn
Leonardo DaVinci
Archimedes
David Hume
- 30 -
Andreas Vesalius
Rudolf Virchow
Richard Feynman
James Hutton
Alexander Fleming
Emile Durkheim
Benjamin Franklin
Robert Oppenheimer
Robert Hooke
Charles Kettering
- 20 -
Carl Sagan
James Maxwell
Marie Curie
Rene Descartes
Francis Crick
Hippocrates
Michael Faraday
Srinivasa Ramanujan
Francis Bacon
Galileo Galilei
- 10 -
Aristotle
John Watson
Rosalind Franklin
Michio Kaku
Isaac Asimov
Charles Darwin
Sigmund Freud
Albert Einstein
Florence Nightingale
Isaac Newton