...I have always maintained that, excepting fools, men did not differ much in intellect, only in zeal and hard work; and I still think there is an eminently important difference.

Ihre Arbeit ist gekrönt worden mit dem Nobel Preis für Otto Hahn.
Her work has been crowned by the Nobel Prize for Otto Hahn.

Parkinson's First Law: Work expands so as to fill the time available for its completion.

[Recalling Professor Ira Remsen's remarks (1895) to a group of his graduate students about to go out with their degrees into the world beyond the university:]
He talked to us for an hour on what was ahead of us; cautioned us against giving up the desire to push ahead by continued study and work. He warned us against allowing our present accomplishments to be the high spot in our lives. He urged us not to wait for a brilliant idea before beginning independent research, and emphasized the fact the Lavoisier's first contribution to chemistry was the analysis of a sample of gypsum. He told u that the fields in which the great masters had worked were still fruitful; the ground had only been scratched and the gleaner could be sure of ample reward.

A body of work such as Pasteur's is inconceivable in our time: no man would be given a chance to create a whole science. Nowadays a path is scarcely opened up when the crowd begins to pour in.

A day of worry is more exhausting than a week of work.

A doctor must work eighteen hours a day and seven days a week. If you cannot console yourself to this, get out of the profession

A man who keeps company with glaciers comes to feel tolerably insignificiant by and by. The Alps and the glaciers together are able to take every bit of conceit out of a man and reduce his self-importance to zero if he will only remain within the influence of their sublime presence long enough to give it a fair and reasonable chance to do its work.

A New Arithmetic: “I am not much of a mathematician,” said the cigarette, “but I can add nervous troubles to a boy, I can subtract from his physical energy, I can multiply his aches and pains, I can divide his mental powers, I can take interest from his work and discount his chances for success.”

According to Gandhi, the seven sins are wealth without works, pleasure without conscience, knowledge without character, commerce without morality, science without humanity, worship without sacrifice, and politics without principle. Well, Hubert Humphrey may have sinned in the eyes of God, as we all do, but according to those definitions of Gandhi’s, it was Hubert Humphrey without sin.

Accurate and minute measurement seems to the non-scientific imagination, a less lofty and dignified work than looking for something new. But nearly all the grandest discoveries of science have been but the rewards of accurate measurement and patient long-continued labour in the minute sifting of numerical results.

All statements about the hydrides of boron earlier than 1912, when Stock began to work upon them, are untrue.

All that we can hope from these inspirations, which are the fruits of unconscious work, is to obtain points of departure for such calculations. As for the calculations themselves, they must be made in the second period of conscious work which follows the inspiration, and in which the results of the inspiration are verified and the consequences deduced.‎

Anything worth doing is worth doing to excess.
[In reference to concentration and hard work.]

Are God and Nature then at strife,
That Nature lends such evil dreams?
So careful of the type she seems,
So careless of the single life; ...
'So careful of the type', but no.
From scarped cliff and quarried stone
She cries, 'A thousand types are gone:
I care for nothing, all shall go' ...
Man, her last work, who seemed so fair,
Such splendid purpose in his eyes,
Who rolled the psalm to wintry skies,
Who built him fanes of fruitless prayer,
Who trusted God was love indeed
And love Creation's final law—
Tho’ Nature red in tooth and claw
With ravine, shrieked against his creed...

Arts and sciences in one and the same century have arrived at great perfection; and no wonder, since every age has a kind of universal genius, which inclines those that live in it to some particular studies; the work then, being pushed on by many hands, must go forward.

But we have reason to think that the annihilation of work is no less a physical impossibility than its creation, that is, than perpetual motion.

Do the day’s work. If it be to protect the rights of the weak, whoever objects, do it. If it be to help a powerful corporation better to serve the people, whatever the opposition, do that. Expect to be called a stand-patter, but don’t be a stand-patter. Expect to be called a demagogue, but don’t be a demagogue. Don’t hesitate to be as revolutionary as science. Don’t hesitate to be as reactionary as the multiplication table. Don’t expect to build up the weak by pulling down the strong. Don’t hurry to legislate. Give administration a chance to catch up with legislation.

Don't be afraid of hard work. Nothing worthwhile comes easily. Don't let others discourage you or tell you that you can't do it. In my day I was told women didn't go into chemistry. I saw no reason why we couldn't.

During Alfvén's visit he gave a lecture at the University of Chicago, which was attended by [Enrico] Fermi. As Alfvén described his work, Fermi nodded his head and said, 'Of course.' The next day the entire world of physics said. 'Oh, of course.'

Even fairly good students, when they have obtained the solution of the problem and written down neatly the argument, shut their books and look for something else. Doing so, they miss an important and instructive phase of the work. ... A good teacher should understand and impress on his students the view that no problem whatever is completely exhausted.

Every physical fact, every expression of nature, every feature of the earth, the work of any and all of those agents which make the face of the world what it is, and as we see it, is interesting and instructive. Until we get hold of a group of physical facts, we do not know what practical bearings they may have, though right-minded men know that they contain many precious jewels, which science, or the expert hand of philosophy will not fail top bring out, polished, and bright, and beautifully adapted to man's purposes.

Every river appears to consist of a main trunk, fed from a variety of branches, each running in a valley proportional to its size, and all of them together forming a system of vallies, communicating with one another, and having such a nice adjustment of their declivities that none of them join the principal valley on too high or too low a level; a circumstance which would be infinitely improbable if each of these vallies were not the work of the stream that flows in it.

Every work of science great enough to be well remembered for a few generations affords some exemplification of the defective state of the art of reasoning of the time when it was written; and each chief step in science has been a lesson in logic.

Famine seems to be the last, the most dreadful resource of nature. The power of population is so superior to the power in the earth to produce subsistence for man, that premature death must in some shape or other visit the human race. The vices of mankind are active and able ministers of depopulation. They are the precursors in the great army of destruction; and often finish the dreadful work themselves. But should they fail in this war of extermination, sickly seasons, epidemics, pestilence, and plague, advance in terrific array, and sweep off their thousands and ten thousands. Should success he still incomplete, gigantic inevitable famine stalks in the rear, and with one mighty blow, levels the population with the food of the world.

For FRICTION is inevitable because the Universe is FULL of God's works.
For the PERPETUAL MOTION is in all works of Almighty GOD.
For it is not so in the engines of man, which are made of dead materials, neither indeed can be.
For the Moment of bodies, as it is used, is a false term—bless God ye Speakers on the Fifth of November.
For Time and Weight are by their several estimates.
For I bless GOD in the discovery of the LONGITUDE direct by the means of GLADWICK.
For the motion of the PENDULUM is the longest in that it parries resistance.
For the WEDDING GARMENTS of all men are prepared in the SUN against the day of acceptation.
For the wedding Garments of all women are prepared in the MOON against the day of their purification.
For CHASTITY is the key of knowledge as in Esdras, Sir Isaac Newton & now, God be praised, in me.
For Newton nevertheless is more of error than of the truth, but I am of the WORD of GOD.

G=A – W
Glück gleich Arbeit weniger Widerstand.
Happiness is equal to work minus resistance.

Great inventions are never, and great discoveries are seldom, the work of any one mind. Every great invention is really an aggregation of minor inventions, or the final step of a progression. It is not usually a creation, but a growth, as truly so as is the growth of the trees in the forest.

He who works with the door open gets all kinds of interruptions, but he also occasionally gets clues as to what the world is and what might be important.

Heat energy of uniform temperature [is] the ultimate fate of all energy. The power of sunlight and coal, electric power, water power, winds and tides do the work of the world, and in the end all unite to hasten the merry molecular dance.

Here's good advice for practice: go into partnership with nature; she does more than half the work and asks none of the fee.

I am always surprised when a young man tells me he wants to work at cosmology. I think of cosmology as something that happens to one, not something one can choose.

I am an experimenter, or rather I used to be one. Then I stopped working, and since then people think I am a theoretician.

I believe scientists have a duty to share the excitement and pleasure of their work with the general public, and I enjoy the challenge of presenting difficult ideas in an understandable way.

I can say, if I like, that social insects behave like the working parts of an immense central nervous system: the termite colony is an enormous brain on millions of legs; the individual termite is a mobile neurone.

I cannot face with comfort the idea of life without work; work and the free play of the imagination are for me the same thing, I take no pleasure in anything else.

I cannot shut my eyes to the fact that the production of wealth is not the work of any one man, and the acquisition of great fortunes is not possible without the co-operation of multitudes of men.

I feel sorry for the person who can't get genuinely excited about his work. Not only will he never be satisfied, but he will never achieve anything worthwhile.

I find I'm luckier when I work harder.

I have destroyed almost the whole race of frogs, which does not happen in that savage Batrachomyomachia of Homer. For in the anatomy of frogs, which, by favour of my very excellent colleague D. Carolo Fracassato, I had set on foot in order to become more certain about the membranous substance of the lungs, it happened to me to see such things that not undeservedly 1 can better make use of that (saying) of Homer for the present matter—
'I see with my eyes a work trusty and great.'
For in this (frog anatomy) owing to the simplicity of the structure, and the almost complete transparency of the vessels which admits the eye into the interior, things are more clearly shown so that they will bring the light to other more obscure matters.

I prefer the spagyric chemical physicians, for they do not consort with loafers or go about gorgeous in satins, silks and velvets, gold rings on their fingers, silver daggers hanging at their sides and white gloves on their hands, but they tend their work at the fire patiently day and night. They do not go promenading, but seek their recreation in the laboratory, wear plain learthern dress and aprons of hide upon which to wipe their hands, thrust their fingers amongst the coals, into dirt and rubbish and not into golden rings. They are sooty and dirty like the smiths and charcoal burners, and hence make little show, make not many words and gossip with their patients, do not highly praise their own remedies, for they well know that the work must praise the master, not the master praise his work. They well know that words and chatter do not help the sick nor cure them... Therefore they let such things alone and busy themselves with working with their fires and learning the steps of alchemy. These are distillation, solution, putrefaction, extraction, calcination, reverberation, sublimination, fixation, separation, reduction, coagulation, tinction, etc.

I regard the brain as a computer which will stop working when its components fail. There is no heaven or afterlife for broken down computers; that is a fairy story for people afraid of the dark.

I think work is a privilege. ... It keeps you alive, spiritually.

If a mathematician wishes to disparage the work of one of his colleagues, say, A, the most effective method he finds for doing this is to ask where the results can be applied. The hard pressed man, with his back against the wall, finally unearths the researches of another mathematician B as the locus of the application of his own results. If next B is plagued with a similar question, he will refer to another mathematician C. After a few steps of this kind we find ourselves referred back to the researches of A, and in this way the chain closes.

If a train station is where the train stops, what is a work station?

If it works, it's obsolete.

If science has no country, the scientist should have one, and ascribe to it the influence which his works may have in this world.

If someday they say of me that in my work I have contributed something to the welfare and happiness of my fellow man, I shall be satisfied.

If the double helix was so important, how come you didn't work on It?
Ther husband, Linus Pauling, when the Nobel Prize was awarded to Crick, Watson and Wilkins.

If to be the Author of new things, be a crime; how will the first Civilizers of Men, and makers of Laws, and Founders of Governments escape? Whatever now delights us in the Works of Nature, that excells the rudeness of the first Creation, is New. Whatever we see in Cities, or Houses, above the first wildness of Fields, and meaness of Cottages, and nakedness of Men, had its time, when this imputation of Novelty, might as well have bin laid to its charge. It is not therefore an offence, to profess the introduction of New things, unless that which is introduc'd prove pernicious in itself; or cannot be brought in, without the extirpation of others, that are better.

If you do not feel equal to the headaches that psychiatry induces, you are in the wrong business. It is work - work the like of which I do not know.

If you don't work on important problems, it's not likely that you'll do important work.

If you have built castles in the air, your work need not be lost; that is where they should be. Now put the foundations under them.

If you've got time to kill, work it to death.

In 1944 Erwin Schroedinger, stimulated intellectually by Max Delbruck, published a little book called What is life? It was an inspiration to the first of the molecular biologists, and has been, along with Delbruck himself, credited for directing the research during the next decade that solved the mystery of how 'like begat like.' Max was awarded this Prize in 1969, and rejoicing in it, he also lamented that the work for which he was honored before all the peoples of the world was not something which he felt he could share with more than a handful. Samuel Beckett's contributions to literature, being honored at the same time, seemed to Max somehow universally accessible to anyone. But not his. In his lecture here Max imagined his imprisonment in an ivory tower of science.

In 1945 J.A. Ratcliffe ... suggested that I [join his group at Cavendish Laboratory, Cambridge] to start an investigation of the radio emission from the Sun, which had recently been discovered accidentally with radar equipment. ... [B]oth Ratcliffe and Sir Lawrence Bragg, then Cavendish Professor, gave enormous support and encouragement to me. Bragg's own work on X-ray crystallography involved techniques very similar to those we were developing for "aperture synthesis", and he always showed a delighted interest in the way our work progressed.

In my work I now have the comfortable feeling that I am so to speak on my own ground and territory and almost certainly not competing in an anxious race and that I shall not suddenly read in the literature that someone else had done it all long ago. It is really at this point that the pleasure of research begins, when one is, so to speak, alone with nature and no longer worries about human opinions, views and demands. To put it in a way that is more learned than clear: the philological aspect drops out and only the philosophical remains.

In such sad circumstances I but see myself exalted by my own enemies, for in order to defeat some small works of mine they try to make the whole rational medicine and anatomy fall, as if I were myself these noble disciplines.

In the 1920s, there was a dinner at which the physicist Robert W. Wood was asked to respond to a toast ... "To physics and metaphysics." Now by metaphysics was meant something like philosophy—truths that you could get to just by thinking about them. Wood took a second, glanced about him, and answered along these lines: The physicist has an idea, he said. The more he thinks it through, the more sense it makes to him. He goes to the scientific literature, and the more he reads, the more promising the idea seems. Thus prepared, he devises an experiment to test the idea. The experiment is painstaking. Many possibilities are eliminated or taken into account; the accuracy of the measurement is refined. At the end of all this work, the experiment is completed and ... the idea is shown to be worthless. The physicist then discards the idea, frees his mind (as I was saying a moment ago) from the clutter of error, and moves on to something else. The difference between physics and metaphysics, Wood concluded, is that the metaphysicist has no laboratory.

In the discovery of lemmas the best aid is a mental aptitude for it. For we may see many who are quick at solutions and yet do not work by method ; thus Cratistus in our time was able to obtain the required result from first principles, and those the fewest possible, but it was his natural gift which helped him to the discovery.

In the end, poverty, putridity and pestilence; work, wealth and worry; health, happiness and hell, all simmer down into village problems.

Inanimate objects are classified scientifically into three categories—those that don't work, those that break down, and those that get lost. The goal of all inanimate objects is to resist man and ultimately to defeat him, and the three major classifications are based on the method each object uses to achieve its purpose

It goes so heavily with my disposition that this goodly frame, the earth, seems to me a sterile promontory. This most excellent canopy the air, look you, this brave o'erhanging, this majestic roof fretted with golden fire—why, it appears no other thing to me than a foul and pestilent congregation of vapours. What a piece of work is a man. How noble in reason, how infinite in faculty, in form and moving, how express and admirable, in action, how like an angel! in apprehension, how like a god—the beauty of the world, the paragon of animals! And yet to me, what is this quintessence of dust? Man delights not me—no, nor woman neither, though by your smiling you seem to say so.

It is clear that there is some difference between ends: some ends are energeia [energy], while others are products which are additional to the energeia.
[The first description of the concept of energy.]

It is important to go into work you would like to do. Then it doesn't seem like work. You sometimes feel it's almost too good to be true that someone will pay you for enjoying yourself. I've been very fortunate that my work led to useful drugs for a variety of serious illnesses. The thrill of seeing people get well who might otherwise have died of diseases like leukemia, kidney failure, and herpes virus encephalitis cannot be described in words.

It is not easy to imagine how little interested a scientist usually is in the work of any other, with the possible exception of the teacher who backs him or the student who honors him.

It is on record that when a young aspirant asked Faraday the secret of his success as a scientific investigator, he replied, 'The secret is comprised in three words— Work, Finish, Publish.'

It is to geometry that we owe in some sort the source of this discovery [of beryllium]; it is that [science] that furnished the first idea of it, and we may say that without it the knowledge of this new earth would not have been acquired for a long time, since according to the analysis of the emerald by M. Klaproth and that of the beryl by M. Bindheim one would not have thought it possible to recommence this work without the strong analogies or even almost perfect identity that Citizen Haüy found for the geometrical properties between these two stony fossils.

It is very desirable to have a word to express the Availability for work of the heat in a given magazine; a term for that possession, the waste of which is called Dissipation. Unfortunately the excellent word Entropy, which Clausius has introduced in this connexion, is applied by him to the negative of the idea we most naturally wish to express. It would only confuse the student if we were to endeavour to invent another term for our purpose. But the necessity for some such term will be obvious from the beautiful examples which follow. And we take the liberty of using the term Entropy in this altered sense ... The entropy of the universe tends continually to zero.

It is very remarkable that while the words Eternal, Eternity, Forever, are constantly in our mouths, and applied without hesitation, we yet experience considerable difficulty in contemplating any definite term which bears a very large proportion to the brief cycles of our petty chronicles. There are many minds that would not for an instant doubt the God of Nature to have existed from all Eternity, and would yet reject as preposterous the idea of going back a million of years in the History of His Works. Yet what is a million, or a million million, of solar revolutions to an Eternity?

It may sound like a lot of work to keep up with organic chemistry, and it is; however, those who haven't the time to do it become subject to decay in the ability to teach and to contribute to the Science—a sort of first-order process the half-life of which can't be much more than a year or two.

It was not noisy prejudice that caused the work of Mendel to lie dead for thirty years, but the sheer inability of contemporary opinion to distinguish between a new idea and nonsense.

It's only through honesty and courage that science can work at all. The Ptolemaic understanding of the solar system was undermined and corrected by the constant pressure of more and more honest reporting.

Life through many long periods has been manifested in a countless host of varying structures, all circumscribed by one general plan, each appointed to a definite place, and limited to an appointed duration. On the whole the earth has been thus more and more covered by the associated life of plants and animals, filling all habitable space with beings capable of enjoying their own existence or ministering to the enjoyment of others; till finally, after long preparation, a being was created capable of the wonderful power of measuring and weighing all the world of matter and space which surrounds him, of treasuring up the past history of all the forms of life, and considering his own relation to the whole. When he surveys this vast and co-ordinated system, and inquires into its history and origin, can he be at a loss to decide whether it be a work of Divine thought and wisdom, or the fortunate offspring of a few atoms of matter, warmed by the anima mundi, a spark of electricity, or an accidental ray of sunshine?

Logic issues in tautologies, mathematics in identities, philosophy in definitions; all trivial, but all part of the vital work of clarifying and organising our thought.

Mathematics is being lazy. Mathematics is letting the principles do the work for you so that you do not have to do the work for yourself

Medals are great encouragement to young men and lead them to feel their work is of value, I remember how keenly I felt this when in the 1890s. I received the Darwin Medal and the Huxley Medal. When one is old, one wants no encouragement and one goes on with one's work to the extent of one's power, because it has become habitual.

More and more of out colleagues fail to understand our work because of the high specialization of research problems. We must not be discouraged if the products of our labor are not read or even known to exist. The joy of research must be found in doing since every other harvest is uncertain.

Morphological information has provided the greatest single source of data in the formulation and development of the theory of evolution and that even now, when the preponderance of work is experimental, the basis for interpretation in many areas of study remains the form and relationships of structures.

My colleagues in elementary particle theory in many lands [and I] are driven by the usual insatiable curiosity of the scientist, and our work is a delightful game. I am frequently astonished that it so often results in correct predictions of experimental results. How can it be that writing down a few simple and elegant formulae, like short poems governed by strict rules such as those of the sonnet or the waka, can predict universal regularities of Nature?

My internal and external life depend so much on the work of others that I must make an extreme effort to give as much as I receive.

My scientific work is motivated by an irresistible longing to understand the secrets of nature and by no other feeling. My love for justice and striving to contribute towards the improvement of human conditions are quite independent from my scientific interests.

Newton took no exercise, indulged in no amusements, and worked incessantly, often spending eighteen or nineteen hours out of the twenty-four in writing.

No engineer can go upon a new work and not find something peculiar, that will demand his careful reflection, and the deliberate consideration of any advice that he may receive; and nothing so fully reveals his incapacity as a pretentious assumption of knowledge, claiming to understand everything.

No organization engaged in any specific field of work ever invents any important developers in that field, or adopts any important development in that field until forced to do so by outside competition.

No research will answer all queries that the future may raise. It is wiser to praise the work for what it has accomplished and then to formulate the problems still to be solved.

No sense being pessimistic, it probably wouldn't work anyway.

Now of the difficulties bound up with the public in which we doctors work, I hesitate to speak in a mixed audience. Common sense in matters medical is rare, and is usually in inverse ratio to the degree of education.

Oh Diamond! Diamond! thou little knowest the mischief done! [Apocryphal]

One machine can do the work of fifty ordinary men. No machine can do the work of one extraordinary man.

One of my guiding principles is don’t do anything that other people are doing. Always do something a little different if you can. The concept is that if you do it a little differently there is a greater potential for reward than if you the same thing that other people are doing. I think that this kind of goal for one’s work, having obviously the maximum risk, would have the maximum reward no matter what the field may be.

One of the symptoms of approaching nervous breakdown is the belief that one's work is terribly important.

One should guard against preaching to the young man success in the customary sense as the aim in life. ... The most important motive for work in school and in life is pleasure in work, pleasure in its result, and the knowledge of the value of the result to the community.

Our moral theorists seem never content with the normal. Why must it always be a contest between fornication, obesity and laziness, and celibacy, fasting and hard labor?

Perhaps the central problem we face in all of computer science is how we are to get to the situation where we build on top of the work of others rather than redoing so much of it in a trivially different way.

Professor Tyndall once said the finest inspiration he ever received was from an old man who could scarcely read. This man acted as his servant. Each morning the old man would knock on the door of the scientist and call, “Arise, Sir: it is near seven o'clock and you have great work to do today.”

Quantum theory—at least in the Heisenberg interpretation—describes the way the world works as a literal moment-to-moment emergence of actual facts out of a background of less factual 'potentia.'

Rejoice when other scientists do not believe what you know to be true. It will give you extra time to work on it in peace. When they start claiming that they have discovered it before you, look for a new project.

Research is the name given the crystal formed when the night's worry is added to the day's sweat.

Science knows no country because knowledge belongs to humanity, and is the torch which illuminates the world. Science is the highest personification of the nation because that nation will remain the first which carries the furthest the works of thought and intelligence.

Should a young scientist working with me come to me after two years of such work and ask me what to do next, I would advise him to get out of science. After two years of work, if a man does not know what to do next, he will never make a real scientist.

That one must do some work seriously and must be independent and not merely amuse oneself in life—this our mother [Marie Curie] has told us always, but never that science was the only career worth following.

The advance of science is not comparable to the changes of a city, where old edifices are pitilessly torn down to give place to new, but to the continuous evolution of zoologic types which develop ceaselessly and end by becoming unrecognisable to the common sight, but where an expert eye finds always traces of the prior work of the centuries past. One must not think then that the old-fashioned theories have been sterile and vain.

The advancement of science is slow; it is effected only by virtue of hard work and perseverance. And when a result is attained, should we not in recognition connect it with the efforts of those who have preceded us, who have struggled and suffered in advance? Is it not truly a duty to recall the difficulties which they vanquished, the thoughts which guided them; and how men of different nations, ideas, positions, and characters, moved solely by the love of science, have bequeathed to us the unsolved problem? Should not the last comer recall the researches of his predecessors while adding in his turn his contribution of intelligence and of labor? Here is an intellectual collaboration consecrated entirely to the search for truth, and which continues from century to century.
[Respecting how the work of prior researchers had enabled his isolation of fluorine.]

The animal frame, though destined to fulfill so many other ends, is as a machine more perfect than the best contrived steam-engine—that is, is capable of more work with the same expenditure of fuel.

The Author of nature has not given laws to the universe, which, like the institutions of men, carry in themselves the elements of their own destruction; he has not permitted in his works any symptom of infancy or of old age, or any sign by which we may estimate either their future or their past duration. He may put an end, as he no doubt gave a beginning, to the present system at some determinate period of time; but we may rest assured, that this great catastrophe will not be brought about by the laws now existing, and that it is not indicated by any thing which we perceive.

The Big Idea that had been developed in the seventeenth century ... is now known as the scientific method. It says that the way to proceed when investigating how the world works is to first carry out experiments and/or make observations of the natural world. Then, develop hypotheses to explain these observations, and (crucially) use the hypothesis to make predictions about the future outcome of future experiments and/or observations. After comparing the results of those new observations with the predictions of the hypotheses, discard those hypotheses which make false predictions, and retain (at least, for the time being) any hypothesis that makes accurate predictions, elevating it to the status of a theory. Note that a theory can never be proved right. The best that can be said is that it has passed all the tests applied so far.

The eye, the window of the soul, is the chief means whereby the understanding can most fully and abundantly appreciate the infinite works of Nature; and the ear is second.

The framing of hypotheses is, for the enquirer after truth, not the end, but the beginning of his work. Each of his systems is invented, not that he may admire it and follow it into all its consistent consequences, but that he may make it the occasion of a course of active experiment and observation. And if the results of this process contradict his fundamental assumptions, however ingenious, however symmetrical, however elegant his system may be, he rejects it without hesitation. He allows no natural yearning for the offspring of his own mind to draw him aside from the higher duty of loyalty to his sovereign, Truth, to her he not only gives his affections and his wishes, but strenuous labour and scrupulous minuteness of attention.

The Fundamental Regulator Paradox ... The task of a regulator is to eliminate variation, but this variation is the ultimate source of information about the quality of its work. Therefore, the better the job a regulator does the less information it gets about how to improve.

The indescribable pleasure—which pales the rest of life's joys—is abundant compensation for the investigator who endures the painful and persevering analytical work that precedes the appearance of the new truth, like the pain of childbirth. It is true to say that nothing for the scientific scholar is comparable to the things that he has discovered. Indeed, it would be difficult to find an investigator willing to exchange the paternity of a scientific conquest for all the gold on earth. And if there are some who look to science as a way of acquiring gold instead of applause from the learned, and the personal satisfaction associated with the very act of discovery, they have chosen the wrong profession.

The influence (for good or ill) of Plato's work is immeasurable. Western thought, one might say, has been Platonic or anti-Platonic, but hardly ever non-Platonic.

The invention of the scientific method and science is, I'm sure we'll all agree, the most powerful intellectual idea, the most powerful framework for thinking and investigating and understanding and challenging the world around us that there is, and it rests on the premise that any idea is there to be attacked. If it withstands the attack then it lives to fight another day and if it doesn't withstand the attack then down it goes. Religion doesn't seem to work like that.

The Johns Hopkins University certifies that John Wentworth Doe does not know anything but Biochemistry. Please pay no attention to any pronouncements he may make on any other subject, particularly when he joins with others of his kind to save the world from something or other. However, he worked hard for this degree and is potentially a most valuable citizen. Please treat him kindly.
[An imaginary academic diploma reworded to give a more realistic view of the value of the training of scientists.]

The leading idea which is present in all our [geological] researches, and which accompanies every fresh observation, the sound of which to the ear of the student of Nature seems echoed from every part of her works, is—Time!—Time!—Time!

The lives of scientists, considered as Lives, almost always make dull reading. For one thing, the careers of the famous and the merely ordinary fall into much the same pattern, give or take an honorary degree or two, or (in European countries) an honorific order. It could be hardly otherwise. Academics can only seldom lead lives that are spacious or exciting in a worldly sense. They need laboratories or libraries and the company of other academics. Their work is in no way made deeper or more cogent by privation, distress or worldly buffetings. Their private lives may be unhappy, strangely mixed up or comic, but not in ways that tell us anything special about the nature or direction of their work. Academics lie outside the devastation area of the literary convention according to which the lives of artists and men of letters are intrinsically interesting, a source of cultural insight in themselves. If a scientist were to cut his ear off, no one would take it as evidence of a heightened sensibility; if a historian were to fail (as Ruskin did) to consummate his marriage, we should not suppose that our understanding of historical scholarship had somehow been enriched.

The longing to behold this pre-established harmony [of phenomena and theoretical principles] is the source of the inexhaustible patience and perseverance with which Planck has devoted himself ... The state of mind which enables a man to do work of this kind is akin to that of the religious worshiper or the lover; the daily effort comes from no deliberate intention or program, but straight from the heart.

The mathematical life of a mathematician is short. Work rarely improves after the age of twenty-five or thirty. If little has been accomplished by then, little will ever be accomplished.

The only thing that can bring joy is work.

The plain message physical science has for the world at large is this, that were our political and social and moral devices only as well contrived to their ends as a linotype machine, an antiseptic operating plant, or an electric tram-car, there need now at the present moment be no appreciable toil in the world.

The powers of nature are never in repose; her work never stands still.

The trouble is that all the investigators proceeded in exactly the same spirit, the spirit that is of scientific curiosity, and with no possibility of telling whether the issue of their work would prove them to be fiends, or dreamers, or angels.

The truth may be puzzling. It may take some work to grapple with. It may be counterintuitive. It may contradict deeply held prejudices. It may not be consonant with what we desperately want to be true. But our preferences do not determine what's true. We have a method, and that method helps us to reach not absolute truth, only asymptotic approaches to the truth—never there, just closer and closer, always finding vast new oceans of undiscovered possibilities. Cleverly designed experiments are the key.

The whole strenuous intellectual work of an industrious research worker would appear, after all, in vain and hopeless, if he were not occasionally through some striking facts to find that he had, at the end of all his criss-cross journeys, at last accomplished at least one step which was conclusively nearer the truth.

The works which this man [Joseph Banks] leaves behind him occupy a few pages only; their importance is not greatly superior to their extent; and yet his name will shine out with lustre in the history of the sciences.

Then we'll work a hundred years without physics and chemistry.
[Response shouted back to Carl Bosch (then still head of IG Farben), who had tried to advise him that if Jewish scientists were forced to leave the country both physics and chemistry would be set back 100 years.]

There can be no thought of finishing, for aiming at the stars, both literally and figuratively, is the work of generations, but no matter how much progress one makes there is always the thrill of just beginning.

There must be a reason why some people can afford to live well. They must have worked for it. I only feel angry when I see waste. When I see people throwing away things we could use.

These results demonstrate that there is a new polymerase inside the virions of RNA tumour viruses. It is not present in supernatents of normal cells but is present in virions of avian sarcoma and leukemia RNA tumour viruses. The polymerase seems to catalyse the incorporation of deoxyrinonucleotide triphosphates into DNA from an RNA template. Work is being performed to characterize further the reaction and the product. If the present results and Baltimore's results with Rauscher leukemia virus are upheld, they will constitute strong evidence that the DNA proviruses have a DNA genome when they are in virions. This result would have strong implications for theories of viral carcinogenesis and, possibly, for theories of information transfer in other biological systems. [Co-author with American virologist Satoshi Mizutani]

To me every hour of the day and night is an unspeakably perfect miracle.

To the average mathematician who merely wants to know his work is securely based, the most appealing choice is to avoid difficulties by means of Hilbert's program. Here one regards mathematics as a formal game and one is only concerned with the question of consistency ... . The Realist position is probably the one which most mathematicians would prefer to take. It is not until he becomes aware of some of the difficulties in set theory that he would even begin to question it. If these difficulties particularly upset him, he will rush to the shelter of Formalism, while his normal position will be somewhere between the two, trying to enjoy the best of two worlds.

Using any reasonable definition of a scientist, we can say that 80 to 90 percent of all the scientists that have ever lived are alive now. Alternatively, any young scientist, starting now and looking back at the end of his career upon a normal life span, will find that 80 to 90 percent of all scientific work achieved by the end of the period will have taken place before his very eyes, and that only 10 to 20 percent will antedate his experience.

We affirm the neutrality of Science ... Science is of no country. ... But if Science has no country, the scientist must keep in mind all that may work towards the glory of his country. In every great scientist will be found a great patriot.

We are stuck with technology when all we really want is just stuff that works. How do you recognize something that is still technology? A good clue is if it comes with a manual.

We cannot rest and sit down lest we rust and decay. Health is maintained only through work. And as it is with all life so it is with science. We are always struggling from the relative to the absolute.

We often hear of people breaking down from overwork, but in nine cases out of ten they are really suffering from worry or anxiety.

We work day after day, not to finish things; but to make the future better ... because we will spend the rest of our lives there.

Whenever there is a hard job to be done I assign it to a lazy man; he is sure to find an easy way of doing it.

Why does this magnificent applied science which saves work and makes life easier bring us so little happiness? ... The simple answer runs: Because we have not yet learned to make sensible use of it.'

With respect to Committees as you would perceive I am very jealous of their formation. I mean working committees. I think business is always better done by few than by many. I think also the working few ought not to be embaras[s]ed by the idle many and further I think the idle many ought not to be honoured by association with the working few.—I do not think that my patience has ever come nearer to an end than when compelled to hear ... long rambling malapropros enquiries of members who still have nothing in consequence to propose that shall advance the business.

Work is of two kinds: first, altering the position of matter at or near the earth's surface relative to other such matter; second, telling other people to do so. The first kind is unpleasant and ill paid; the second is pleasant and highly paid.

Working is beautiful and rewarding, but acquisition of wealth for its own sake is disgusting.
A comment Bunsen often told his students.

Wouldst thou enjoy a long Life, a healthy Body, and a vigorous Mind, and be acquainted also with the wonderful Works of God? labour in the first place to bring thy Appetite into Subjection to Reason.

You may say organize, organize, organize; but there may be so much organization that it will interfere with the work to be done.

[Benjamin Peirce's] lectures were not easy to follow. They were never carefully prepared. The work with which he rapidly covered the blackboard was very illegible, marred with frequent erasures, and not infrequent mistakes (he worked too fast for accuracy). He was always ready to digress from the straight path and explore some sidetrack that had suddenly attracted his attention, but which was likely to have led nowhere when the college bell announced the close of the hour and we filed out, leaving him abstractedly staring at his work, still with chalk and eraser in his hands, entirely oblivious of his departing class.

[Great scientists] are men of bold ideas, but highly critical of their own ideas: they try to find whether their ideas are right by trying first to find whether they are not perhaps wrong. They work with bold conjectures and severe attempts at refuting their own conjectures.

[In] the realm of science, ... what we have achieved will be obsolete in ten, twenty or fifty years. That is the fate, indeed, that is the very meaning of scientific work. ... Every scientific “fulfillment” raises new “questions” and cries out to be surpassed rendered obsolete. Everyone who wishes to serve science has to resign himself to this.

[Louis Rendu, Bishop of Annecy] collects observations, makes experiments, and tries to obtain numerical results; always taking care, however, so to state his premises and qualify his conclusions that nobody shall be led to ascribe to his numbers a greater accuracy than they merit. It is impossible to read his work, and not feel that he was a man of essentially truthful mind and that science missed an ornament when he was appropriated by the Church.

[Otto Struve] made the remark once that he never looked at the spectrum of a star, any star, where he didn’t find something important to work on.

[The blame for the future 'plight of civilization] must rest on scientific men, equally with others, for being incapable of accepting the responsibility for the profound social upheavals which their own work primarily has brought about in human relationships.

[The] complex pattern of the misallocation of credit for scientific work must quite evidently be described as 'the Matthew effect', for, as will be remembered, the Gospel According to St. Matthew puts it this way: For unto every one that hath shall be given, and he shall have abundance: but from him that hath not shall be taken away even that which he hath. Put in less stately language, the Matthew effect consists of the accruing of greater increments of recognition for particular scientific contributions to scientists of considerable repute and the withholding of such recognition from scientists who have not yet made their mark.

[The] weakness of biological balance studies has aptly been illustrated by comparison with the working of a slot machine. A penny brings forth one package of chewing gum; two pennies bring forth two. Interpreted according to the reasoning of balance physiology, the first observation is an indication of the conversion of copper into gum; the second constitutes proof.
[Co-author with David Rittenberg (1906-70).]